25 research outputs found

    Polymorphisms in <em>CTLA4</em> Influence Incidence of Drug-Induced Liver Injury after Renal Transplantation in Chinese Recipients

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    <div><p>Genetic polymorphisms in cytotoxic T lymphocyte-associated antigen 4 (CTLA4) play an influential role in graft rejection and the long-term clinical outcome of organ transplantation. We investigated the association of 5 CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) recipients. Each recipient underwent a 24-month follow-up observation for drug-induced liver damage. The CTLA4 SNPs were genotyped in 864 renal transplantation recipients. A significant association was found between the rs231775 genotype and an early onset of DILI in the recipients. Multivariate analyses revealed that a risk factor, recipient rs231775 genotype (p = 0.040), was associated with DILI. Five haplotypes were estimated for 4 SNPs (excluding rs733618); the frequency of haplotype ACGG was significantly higher in the DILI group (68.9%) than in the non-DILI group (61.1%) (p = 0.041). In conclusion, CTLA4 haplotype ACGG was partially associated with the development of DILI in Chinese kidney transplant recipients. The rs231775 GG genotype may be a risk factor for immunosuppressive drug-induced liver damage.</p> </div

    Diagnosis time of drug-induced liver injury after renal transplantation.

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    <p>Twenty-three patients were diagnosed drug-induced liver injury within the first month after operation; 26, 22 and 19 cases presented with DILI between 2 and 6 months, 7 and 12 months and 13 and 24 months after operation, respectively.</p

    Association between DILI and several risk factors.

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    <p>CsA: cyclosporine, MMF: mycophenolate mofetil, Pred: prednisone, TAC: tacolimous, AR: acute rejection, non-AR: non-acute rejection, DILI: drug induced liver injury.</p

    Association between <i>CTLA4</i> SNPs and early onset of drug-induced liver injury in renal transplantation.

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    <p>No statistical differences for rs733618 (Figure 2a), rs4553808 (Figure 2b), rs5742909 (Figure 2c) or rs3087243(Figure 2e) was found between DILI and non-DILI recipients. A significant difference (p = 0.039) was found between patients bearing the rs231775 GG genotype and those with the AA+AG genotypes using the log-rank test (Figure 2d).</p

    Comparison of clinical characteristics between patients with DILI and non-DILI.

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    <p>CsA: cyclosporine, MMF: mycophenolate mofetil, Pred: prednisone, TAC: tacolimous, AR: acute rejection, non-AR: non-acute rejection, DILI: drug induced liver injury.</p
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