Voronoi generation tree based on “divide-and-conquer” method.

<p>Voronoi generation tree based on “divide-and-conquer” method.</p

Time comparison of different data partition policy in Tab.4.

<p>Time comparison of different data partition policy in Tab.4.</p

Several basic Voronoi diagram generation results.

<p><b>(a)</b> Voronoi calculation method for a line segment. <b>(b)</b> Voronoi calculation method for a point and a line segment. <b>(c)</b> Voronoi calculation method for two segments. <b>(d)</b> Voronoi calculation method (∠<i>ABC</i> is an acute angle). <b>(e)</b> Voronoi calculation method (∠<i>ABC</i> is an obtuse angle).</p

Voronoi diagram generation algorithm based on the binary tree principle for a simple polygon.

<p>Voronoi diagram generation algorithm based on the binary tree principle for a simple polygon.</p

Comparison charts of medial axis simplification and LIC seeking.

<p>Comparison charts of medial axis simplification and LIC seeking.</p

The algorithm to find the LIC based on Voronoi and medial axis.

<p><b>(a)</b> Voronoi diagram of a simple polygon. <b>(b)</b> Medial axis diagram of a simple polygon. <b>(c)</b> Voronoi diagram of a complex polygon. <b>(d)</b> Medial axis diagram of a complex polygon.</p

DataSheet_1_Case Report: Osimertinib Followed by Osimertinib Plus Bevacizumab, Personalized Treatment Strategy for a Lung Cancer Patient With a Novel EGFR Exon 20 Insertion D770_N771insGT and Multiple Brain Metastases.pdf

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) are the standard of care for non–small cell lung cancer (NSCLC) patients with EGFR exon 19 deletion and L858R mutations. However, no EGFR TKI has been approved for NSCLC patients harboring insertion mutations in EGFR exon 20 (EGFRex20ins), a subgroup of uncommon EGFR mutations resistant to first-generation EGFR TKIs. This unmet clinical challenge is further complicated by disease progression due to brain metastases (BMs), which limits the use of EGFR TKIs with low intracranial activity. Osimertinib, a third-generation EGFR TKI with high CNS activity, has demonstrated superior efficacy as a first-line treatment for EGFR-mutant NSCLC with or without BM. The VEGF pathway is a key mediator of cancer metastasis and resistance to EGFR TKIs. Accumulating evidence has demonstrated that the addition of anti-VEGF agents to EGFR TKIs provides an alternative treatment option for the clinical management of EGFR-mutant NSCLC. We herein report an NSCLC case with a novel EGFRex20ins mutation D770_N771insGT and multiple brain metastases who briefly responded to first-line osimertinib treatment and subsequently achieved prolonged disease control with osimertinib plus bevacizumab as second-line treatment. Our case suggests that osimertinib in combination with bevacizumab may be an effective option for NSCLC patients with specific EGFRex20ins mutations and brain metastases.</p

Viscoelasticity of Polymers with Dynamic Covalent Bonds: Concepts and Misconceptions

Polymers with dynamic covalent bonds are an exciting class of materials with properties and potential applications that rapidly gain significant attention from diverse scientific communities. While the number of publications on this emerging topic increases exponentially, navigating through this literature reveals a series of physical inconsistencies in previously established concepts and some misconceptions in data analysis and interpretation. The current paper presents an analysis of practices often applied to the characterization of systems with dynamic bonds and emphasizes particular misconceptions that may lead to critical divergences and misinterpretations of the results. We particularly focus on practices that should be avoided in the interpretation of stress–relaxation and viscoelastic data and in estimates of the bond dissociation energy. Instead, we suggest using traditional approaches that have been applied to the analysis of polymer viscoelastic properties for decades. Lastly, we emphasize the current challenges in a full understanding of the microscopic behavior of vitrimers

Self-Healable, Highly Stretchable, Ionic Conducting Polymers as Efficient Protecting Layers for Stable Lithium-Metal Electrodes

Although numerous studies on polymeric protective films to stabilize lithium (Li)-metal electrodes have been reported, the construction of self-healing polymers that enables the long-term operation of Li-metal batteries (LMBs) at relatively low temperatures has rarely been demonstrated. Herein, a highly stretchable, autonomous self-healable, and ionic-conducting polymer network (SHIPN) is synthesized as an efficient protective film for LMBs. The network backbone, synthesized from copolymerization of poly­(ethylene glycol)-mono-methacrylate (PEGMMA) and 2-[[(butylamino)­carbonyl]­oxy]­ethyl acrylate (BCOE), is chemically cross-linked via diisocyanate. With SHIPN-modified electrodes, enhanced electrochemical performance can be achieved in Li/Cu, Li/Li, and Li/LiFePO4 (Li/LFP) cells. The SHIPN@Li/LFP cell delivers a capacity retention of 85.6% after 500 cycles at 5 °C, resulting from the low-temperature self-healability of SHIPN. In full cells with a high-mass-loading LFP cathode (∼17 mg cm–2), the capacity retention is at least 300% higher than that with a bare Li electrode. Further physical characterizations of electrodes confirm the effect of SHIPN in enhancing the interfacial stability and suppressing Li dendrite growth. Our results will provide insights into rationally designing soft and hybrid materials toward stable LMBs at different temperatures