Table_2_Screening for key genes in circadian regulation in advanced atherosclerosis: A bioinformatic analysis.XLSX

BackgroundAtherosclerosis (AS) is the most important cardiovascular disease threatening human health, leading to adverse events such as myocardial infarction and stroke. The research on the pathogenesis and causes of AS is being improved step by step, and many factors are associated with AS. However, the relationship between circadian regulation and the pathogenesis of AS is still unclear. Our study identified 2 key genes of circadian regulation in AS by bioinformatics analysis, which provides new perspectives to understand the relationship between circadian rhythm and AS.MethodsWe downloaded samples of early and advanced AS from public databases, screened key genes by weighted gene co-expression network analysis (WGCNA) and Lasso, calculated the immune cell content of the samples using “CIBERSORT,” and analyzed the relationship between key genes and immune cells.ResultsWe obtained the most relevant core modules for advanced AS and analyzed the functions of these modules. Two circadian rhythm-related genes were obtained, which influence the immune infiltration of this late AS. ROC curves demonstrated the efficacy of key genes to differentiate between early and advanced AS.ConclusionWe identified 2 genes most associated with circadian rhythms in advanced AS, whose association with AS has not been elucidated and may become the next therapeutic target.</p

Table_1_Screening for key genes in circadian regulation in advanced atherosclerosis: A bioinformatic analysis.XLSX

BackgroundAtherosclerosis (AS) is the most important cardiovascular disease threatening human health, leading to adverse events such as myocardial infarction and stroke. The research on the pathogenesis and causes of AS is being improved step by step, and many factors are associated with AS. However, the relationship between circadian regulation and the pathogenesis of AS is still unclear. Our study identified 2 key genes of circadian regulation in AS by bioinformatics analysis, which provides new perspectives to understand the relationship between circadian rhythm and AS.MethodsWe downloaded samples of early and advanced AS from public databases, screened key genes by weighted gene co-expression network analysis (WGCNA) and Lasso, calculated the immune cell content of the samples using “CIBERSORT,” and analyzed the relationship between key genes and immune cells.ResultsWe obtained the most relevant core modules for advanced AS and analyzed the functions of these modules. Two circadian rhythm-related genes were obtained, which influence the immune infiltration of this late AS. ROC curves demonstrated the efficacy of key genes to differentiate between early and advanced AS.ConclusionWe identified 2 genes most associated with circadian rhythms in advanced AS, whose association with AS has not been elucidated and may become the next therapeutic target.</p

All-Inorganic Zero-Dimensional Sn-Doped Rb₄CdCl₆ with Near-Unity Quantum Efficiency

Zero-dimensional (0D) metal halide perovskites (MHPs) have attracted much attention due to their unique crystal and electronic structure. Drastically different from three-dimensional (3D) CsPbCl3 analogues, 0D perovskites exhibit broadband emission spectra of self-trapped excitons (STEs) with a large Stokes shift and high exciton binding energy. However, their luminescent efficiencies are much lower than those of the 3D ones. Herein, for the first time, we successfully synthesized the Sn2+-doped 0D Rb4CdCl6 with an emission at 485 nm by a simple hydrothermal method. Importantly, the host with a doping of 0.239 Sn shows a near-unity quantum efficiency (PLQY ∼98.04%) under UV light excitation, which is the highest among Cd-based all-inorganic MHPs. The results from temperature-dependent PL spectra suggested that the emission might originate from STEs, where this broad emission is attributed to the 3P1 to 1S0 radiation transition of octahedral [SnCl6]4– units in the host matrix. As a result, the as-prepared doped crystals exhibit large Stokes shifts and high quantum efficiency. Our work successfully elucidates that the Sn2+ dopant plays an integral role in improving PLQY of 0D MHPs. This kind of Sn2+-doped promising luminescent materials may have significant applications in optoelectronic devices

Mapping the Space of Inorganic and Hybrid Halides and Their Optical Properties Using Mechanochemistry and First-Principles Calculations

Inorganic and hybrid metal halides (MHs) are a class of ionic compounds that attract growing interest due to their richness of structure, properties, and resulting applications. These are largely ionic in nature and hence dominantly follow solid-state synthesis reactions rather than the solution approach. Keeping the importance of these materials in mind, herein, combination reactions of compounds via mechanochemistry is considered as a universal synthetic approach for the synthesis of MHs, and a library of MHs, including all inorganic MHs, ternary (A–B–X) MHs, enormous number of quaternary MHs based on representative 10 double perovskites (A–B–B′–X), and most of the hybrid ones based on randomly selected 49 samples as representative from the 1300 ones, are reported. The fundamental structure–property relationships are well revealed, where most of the MHs exhibit bright photoluminescence and/or magnetic properties for a few materials. Hence, the adopted concept of material design and related with their crystal structure and material properties for such a large number of halide materials not only help in building a library but also provide fundamental guidance to develop new MH materials with selective optoelectronic and magnetic properties.

Single-shot polarization-resolved ultrafast mapping photography

Single-shot ultrafast optical imaging plays a very important role in the detection of transient scenes, especially in capturing irreversible or stochastic dynamic scenes. To break the limit of time response speed of electronic devices, such as charge-coupled device (CCD) or complementary metal-oxide-semiconductor (CMOS) detectors, ultrafast optical imaging techniques usually convert the time information of a transient scene into the wavelength, angle, space or spatial frequency of the illumination light in previous studies. In this work, we propose a novel polarization-resolved ultrafast mapping photography (PUMP) technique by converting the time information into the polarization. Here, the spatiotemporal information of a dynamic scene is loaded into a rotationally polarized illumination laser pulse, and a polarization filtering in imaging detection and a deconvolution algorithm in image reconstruction are used to extract the original dynamic scene. In our PUMP system, the temporal resolution is 850 fs, the spatial resolution is 28.5 lp/mm at 700 micrometer by 700 micrometer field of view, and the number of frames is 16. By using PUMP, a spatiotemporal dynamics of femtosecond laser ablation in an indium tin oxide film on glass substrate is successfully captured. PUMP provides a new solution for measuring the transient scenes in a snapshot, which will bring a very wide range of applications in the field of ultrafast science

Supplementary document for A flexible and accurate total variation and cascaded denoisers-based image reconstruction algorithm for hyperspectrally compressed ultrafast photography - 6744828.pdf

Supplemental Documen

A flexible and accurate total variation and cascaded denoisers-based image reconstruction algorithm for hyperspectrally compressed ultrafast photography

Hyperspectrally compressed ultrafast photography (HCUP) based on compressed sensing and the time- and spectrum-to-space mappings can simultaneously realize the temporal and spectral imaging of non-repeatable or difficult-to-repeat transient events passively in a single exposure. It possesses an incredibly high frame rate of tens of trillions of frames per second and a sequence depth of several hundred, and plays a revolutionary role in single-shot ultrafast optical imaging. However, due to the ultra-high data compression ratio induced by the extremely large sequence depth as well as the limited fidelities of traditional reconstruction algorithms over the reconstruction process, HCUP suffers from a poor image reconstruction quality and fails to capture fine structures in complex transient scenes. To overcome these restrictions, we propose a flexible image reconstruction algorithm based on the total variation (TV) and cascaded denoisers (CD) for HCUP, named the TV-CD algorithm. It applies the TV denoising model cascaded with several advanced deep learning-based denoising models in the iterative plug-and-play alternating direction method of multipliers framework, which can preserve the image smoothness while utilizing the deep denoising networks to obtain more priori, and thus solving the common sparsity representation problem in local similarity and motion compensation. Both simulation and experimental results show that the proposed TV-CD algorithm can effectively improve the image reconstruction accuracy and quality of HCUP, and further promote the practical applications of HCUP in capturing high-dimensional complex physical, chemical and biological ultrafast optical scenes

Design and Green Synthesis of Piperlongumine Analogs and Their Antioxidant Activity against Cerebral Ischemia-Reperfusion Injury

The supplementation of exogenous antioxidants to scavenge excessive reactive oxygen species (ROS) is an effective treatment for cerebral ischemia-reperfusion injury (CIRI) in stroke. Piperlongumine (PL), a natural alkaloid, has a great potential as a neuroprotective agent, but it also has obvious toxicity. Moreover, its neuroprotective effects remain to be improved. In this study, we designed a series of novel PL analogs by hybridizing the screened low-toxicity diketene skeleton with antioxidant effect and the 3,4,5-trimethoxyphenyl group, which may increase the antioxidant activity of PL. The intermediate was synthesized by a novel green synthesis method, and 34 compounds were obtained. The compounds without obvious cytotoxicity have remarkable antioxidant effects, especially compared with diketene skeletons and PL. The cytoprotection of the active compound decreased significantly by reduction of the carbon–carbon double bonds of the Michael acceptor in the diketene skeleton. More importantly, further study revealed that compound A9, which has the best activity, can confer protection for cells against oxidative stress and attenuate brain injury in vivo. Overall, this study provided a promising drug candidate for the treatment of CIRI and guided the further development of drug research in oxidative stress-mediated diseases

Design, synthesis, and evaluation of cyclic C7-bridged monocarbonyl curcumin analogs containing an <i>o</i>-methoxy phenyl group as potential agents against gastric cancer

The structure-activity relationship (SAR) between toxicity and the types of linking ketones of C7 bridged monocarbonyl curcumin analogs (MCAs) was not clear yet. In the pursuit of effective and less cytotoxic chemotherapeutics, we conducted a SAR analysis using various diketene skeletons of C7-bridged MCAs, synthesized cyclic C7-bridged MCAs containing the identified low-toxicity cyclopentanone scaffold and an o-methoxy phenyl group, and assessed their anti-gastric cancer activity and safety profile. Most compounds exhibited potent cytotoxic activities against gastric cancer cells. We developed a quantitative structure-activity relationship model (R2 > 0.82) by random Forest method, providing important information for optimizing structure. An optimized compound 2 exhibited in vitro and in vivo anti-gastric cancer activity partly through inhibiting the AKT and STAT3 pathways, and displayed a favorable in vivo safety profile. In summary, this paper provided a promising class of MCAs and a potential compound for the development of chemotherapeutic drugs.</p

Additional file 1: of Socio-demographic and maternal predictors of adherence to 24-hour movement guidelines in Singaporean children

Table S1. Which of the following activities did your child do yesterday and last weekend? (If yes, record the times for each activity). Table S2. Proportion (%) of children meeting no guidelines, screen viewing (SV), moderate-to-vigorous physical activity (MVPA), sleep duration recommendations and combinations of these recommendations, overall and by socio-demographic and maternal predictors. (DOCX 17 kb)