2,936 research outputs found

    Didemnin B: Comparative study and conformational approach in solution

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    A comparative study of isodideimnine-1 and didemnin B is presented using spcctroecopic methods, partial degradation and partial synthesis. This leads to the conclusion of the presence of a single depsipeptide, namely didemnin B, with (3S,4R,5S) isostatine instead of the previous statine residue. An attempt to determine the whole conformation in solution of didemnin B by using 2D-NMR is also described

    Extension of SPIS to simulate dust electrostatic charging, transport and contamination of lunar probes

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    A modification of the Spacecraft Plasma Interaction Software has been undertaken under ESA contract 4000107327/12/NL/AK (SPIS-DUST). The primary goal is to provide mission designers with an engineering tool capable of predicting charged dust behavior in a given plasma environment involving a spacecraft / exploration unit in contact with complex topological features at various locations of the Moon’s surface. The tool also aims at facilitating dust contamination diagnostics for sensitive surfaces such as sensors optics, solar panels, thermal interfaces, etc. In this paper, the new user interface and the new numerical solvers developed in the frame of this project is presented. The pre-processing includes the building of a 3D lunar surface from a topology description (i.e. a point list), an interface to position the spacecraft and a merging interface for the spacecraft elements in contact with the lunar surface. Concerning the physical models, the new solvers have been developed in order to model the physics of the ejection of the dust from the soils, the dusts charging and transport in volume and the dust interaction and contamination of the spacecraft. The post-processing includes the standard outputs of SPIS for the electrostatic computation and the plasma plus dedicated instruments for the diagnosis of the dusts. A set of verification test cases are presented in order to demonstrate the new capabilities of this version of SPIS in realistic conditions

    Analysis of the dynamic co-expression network of heart regeneration in the zebrafish.

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    The zebrafish has the capacity to regenerate its heart after severe injury. While the function of a few genes during this process has been studied, we are far from fully understanding how genes interact to coordinate heart regeneration. To enable systematic insights into this phenomenon, we generated and integrated a dynamic co-expression network of heart regeneration in the zebrafish and linked systems-level properties to the underlying molecular events. Across multiple post-injury time points, the network displays topological attributes of biological relevance. We show that regeneration steps are mediated by modules of transcriptionally coordinated genes, and by genes acting as network hubs. We also established direct associations between hubs and validated drivers of heart regeneration with murine and human orthologs. The resulting models and interactive analysis tools are available at http://infused.vital-it.ch. Using a worked example, we demonstrate the usefulness of this unique open resource for hypothesis generation and in silico screening for genes involved in heart regeneration

    Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

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    This paper presents measurements of the W+→Ό+ÎœW^+ \rightarrow \mu^+\nu and W−→Ό−ΜW^- \rightarrow \mu^-\nu cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13

    Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector