Copper-Catalyzed Alkylation of Benzoxazoles with Secondary Alkyl Halides

Copper-catalyzed direct alkylation of benzoxazoles using nonactivated secondary alkyl halides has been developed. The best catalyst is a new copper(I) complex (<b>1</b>), and the reactions are promoted by bis[2-(<i>N</i>,<i>N</i>-dimethylamino)ethyl] ether

Copper-Catalyzed Alkylation of Benzoxazoles with Secondary Alkyl Halides

Copper-catalyzed direct alkylation of benzoxazoles using nonactivated secondary alkyl halides has been developed. The best catalyst is a new copper(I) complex (<b>1</b>), and the reactions are promoted by bis[2-(<i>N</i>,<i>N</i>-dimethylamino)ethyl] ether