Mean values of S-Fructosamine, S-Glucose and B-HbA1c over time by increase/reduction of S-Glucose at on average 290 days after the index examination.

<p>Fasting subjects with new or diagnosed type 2 diabetes and with three simultaneous measurements of the biomarkers within one year are included.</p

Correlations of S-Fructosamine and B-HbA_1c by fasting status, type 2 diabetes (new and diagnosed) and type 1 diabetes.

<p>Fitted regression line with 95% confidence and prediction limits. Reference lines at fructosamine 2.5<b> </b>mmol/L and at HbA_1c 6.5% (48<b> </b>mmol/mol).</p

Overall associations of S-Fructosamine with S-Glucose and B-HbA_1c respectively.

<p>All fasting states and all levels of glycemia included (All subjects).</p

Subject characteristics by glucose and fasting status.

<p>Data are presented as n, mean (SD) or %. *on average 50–60% reduction in n.</p>†<p>Significant difference between groups, except between NewT2D and DiagnosedT2D,</p>‡<p>% only mandatory education.^§Glomerular filtration rate (eGFR) was estimated by the Epidemiology Collaboration (CKD-EPI) formula (26).</p>£<p>Classification of chronic kidney disease was defined as an eGFR less than 60 mL/min per 1.73 m². Abbreviations: BMI = Body Mass Index, S-Alb = Serum Albumin, S-TG = Serum Triglycerides, S-TC = Serum Total Cholesterol, S-LDLC = Serum Low Density Lipoprotein Cholesterol, S-HDLC = Serum Low Density Lipoprotein Cholesterol, ApoB = Apolipoprotein B, ApoA-I = Apolipoprotein A-I, ApoB/ApoA = Ratio of Apolipoprotein B and Apolipoprotein A-I, S-Crea = Serum Creatinine, CKD = Chronic Kidney Disease, CVD = Cardiovascular Disease, S-Fructosamine = Serum Fructosamine, S-Glucose = Serum Glucose.</p><p>Subject characteristics by glucose and fasting status.</p

Hazard ratios for the risk of different types of cancer for groups of population based on tertiles of overall mean glucose and fructosamine.

<p>All models were adjusted for age, SES, fasting status, history of diabetes, lung and cardiovascular disease, serum albumin, total cholesterol and triglycerides. Additional adjustment for sex was performed for colorectal and lung cancer, as well as for parity and age at first childbirth for breast cancer. P-values for interaction were 0.29, 0.93, 0.01, and 0.08 for prostate, breast, colorectal and lung cancer, respectively.</p

Hazard ratios for overall cancer risk for standardized log fructosamine in different tertiles of glucose in fasting population.

<p>The model was adjusted for age, sex, SES, fasting status, history of diabetes, lung and cardiovascular disease, serum albumin, total cholesterol and triglycerides.</p

Hazard ratios and confidence intervals for the risk of overall and different types of cancer for standardized log overall mean glucose and fructosamine.

*<p>Interaction between glucose and fructosamine in relation to cancer risk.</p>1<p>Standardized log glucose and fructosamine were each analyzed in separated models; adjusted for age.</p>2<p>Adjusted for age, sex, SES, fasting status, history of diabetes, lung and cardiovascular disease, serum albumin, total cholesterol and triglycerides.</p>3<p>Subcohort of those with BMI values (N = 2,828).</p>4<p>Subcohort of nondiabetic persons, defined as those with serum glucose level <7.0 mmol/L at all measurements and without registered hospital discharge diagnosis of diabetes mellitus prior to the date of last measurement (N = 10,743); not adjusted for history of diabetes.</p>5<p>Subcohort of fasting persons; not adjusted for fasting status (N = 5,026);</p>6<p>Stratified analysis by glucose tertiles to evaluate the interaction between glucose and fructosamine; standardized log glucose was not included in the model.</p>7<p>Sex-stratified analysis in men; not adjusted for sex.</p>8<p>Sex-stratified analysis in women; not adjusted for sex; adjusted for parity and age at first childbirth.</p

Hazard ratios for overall cancer risk for groups of population based on tertiles of overall mean glucose and fructosamine.

<p>All models were adjusted for age, sex, SES, fasting status, history of diabetes, lung and cardiovascular disease, serum albumin, total cholesterol and triglycerides. P-value for interaction was 0.77.</p

Comparison between population with repeated measurements and single measurement of glucose and fructosamine in the AMORIS Study.

*<p>Standardized log glucose and fructosamine were each analyzed in the same models; adjusted for age, sex, SES, fasting status, history of diabetes, lung and cardiovascular disease, serum albumin, total cholesterol and triglycerides.</p