134 research outputs found

    XXXVII COMU Scientific Awards

    Get PDF
    [...] This year we accepted 41 scientific projects to apply for the traditional and renowned Oswaldo Cruz Awards, Panel Awards and Monograph Awards. All the projects were evaluated focusing to improve the medical formation, excellence in teaching, commitment to the research and to prepare qualifiedprofessional. [...

    Synthesis of Ent-16-hydroxycleroda-4(18),13-dien-15,16-olide and Ent-cleroda-4(18),13-dien-15,16-olide from (+)-hardwickiic acid

    Get PDF
    The absolute configurations of two natural diterpene butenolides were confirmed through the synthesis of ent-16-hydroxycleroda-4(18),13-dien-15,16-olide (2) and ent-cleroda-4(18),13-dien-15,16-olide (3), enantiomers of the natural products, starting from (+)-hardwickiic acid (1).As configura√ß√Ķes absolutas de dois diterpenos butenolidos naturais foram confirmadas atrav√©s da s√≠ntese do ent-16-hidroxicleroda-4(18),13-dien-15,16-olida (2) e ent-cleroda-4(18),13-dien-15,16-olida (3), enanti√īmeros de produtos naturais, a partir do √°cido (+)-hardwickiico (1).417420Funda√ß√£o de Amparo √† Pesquisa do Estado de S√£o Paulo (FAPESP

    Lombalgia

    Get PDF
    A lombalgia √© uma das queixas mais comuns no ser humano. V√°rias s√£o as raz√Ķes de sua ocorr√™ncia. Dentre elas¬†destacam-se as de origem m√ļsculo-esquel√©tica, incluindo especialmente, as s√≠ndromes dolorosas miofasciais. Os dados de hist√≥ria¬†e de exame f√≠sico s√£o a base do diagn√≥stico das etiologias e nosologias das lombalgias. A investiga√ß√£o diagn√≥stica com exames¬†laboratoriais, eletrofisiol√≥gicos e de imagens deve ter seus achados validados com base no exame cl√≠nico e na hist√≥ria. O tratamento¬†√© fundamentado no controle dos sintomas e de suas repercuss√Ķes f√≠sicas e psicossociais e na restaura√ß√£o da funcionalidade das¬†estruturas regionais.Lumbalgia is one the of most common reasons of chronic pain, specially in adults. Many are the causes of lumbalgia;¬†the most frequent aetiology are the muscleskeletal conditions, mainly the myofascial pain syndromes. The data of the history and¬†clinical examination are more important for the diagnosis those that the complementary exams; the laboratorial, electrophysiological¬†and image exams should be vailidated with clinical basis. The treatment of lumbalgia is based on the aleviation of symptoms,¬†removal of the aetiological factors and on the restoration of the physiology of the elements of the lumbar region

    Spectrum of topics for world congresses and other activities of the International Society for Physical and Rehabilitation Medicine (ISPRM) : a first proposal

    Get PDF
    Background: One of the objectives of the International Society for Physical and Rehabilitation Medicine is to improve the continuity of World Congresses. This requires the development of an abstract topic list for use in congress announcements and abstract submissions. Methods: An abstract topic list was developed on the basis of the definitions of human functioning and rehabilitation research, which define 5 main areas of research (biosciences in rehabilitation, biomedical rehabilitation sciences and engineering, clinical Physical and Rehabilitation Medicine (PRM) sciences, integrative rehabilitation sciences, and human functioning sciences). For the abstract topic list, these research areas were grouped according to the proposals of congress streams. In a second step, the first version of the list was systematically compared with the topics of the 2003 ISPRM World Congress. Results: The resulting comprehensive abstract topic list contains 5 chapters according to the definition of human functioning and rehabilitation research. Due to the high significance of clinical research, clinical PRM sciences were placed at the top of the list, comprising all relevant health conditions treated in PRM services. For congress announcements a short topic list was derived. Discussion: The ISPRM topic list is sustainable and covers a full range of topics. It may be useful for congresses and elsewhere in structuring research in PRM

    Tratamento e follow-up da tendinite patelar (jumper's knee) com eletroacupuntura Ryodoraku

    Get PDF
    Patellar tendinitis is a common lesion in athletes who are involved in some type of repeti tive activity of the extensor mechanism of the knee such as jumping, running, bicycling or kicking. This study evaluated the therapeutic effects of electroacupuncture Ryodoraku on stage three patella tendinitis in 58 cases (66 knees). Complete rilief of pain and return to previous activity levei was observed in 43 patients (74,1 %). It was concluded that electrocupuncture Ryodoraku in an efficient method in treating patella tendinitis, easy execution, and low cost, requiring only a few sections to obtain pain relief.A tendinite da patela √© uma les√£o comum em atletas que utilizam repetidamente o mecanismo desacelerador do m√ļsculo extensor do joelho, como nos saltos, corridas, ciclismos e chute. Os autores apresentam os resultados do tratamento conservador de 58 doentes (66 joelhos) portadores de tendinite patelar grau 3 atrav√©s da Eletroampuntura Ryodoraku. Al√≠vio completo da dor e retorno da dor √† atividade esportiva pr√©via foi observado em 43 casos (74,1%). Os autores concluem que a Eletroacupuntura Ryodoraku √© um m√©todo eficaz, de f√°cil execu√ß√£o e baixo custo operacional; necessitando um pequeno n√ļmero de aplica√ß√Ķes para a obten√ß√£o do al√≠vio da dor

    Intra-hospital complications in acute traumatic spinal cord injury

    Get PDF
    H√° poucos dados sobre complica√ß√Ķes hospitalares em pacientes com LMT aguda. Objetivo: Reportar as caracter√≠sticas de complica√ß√Ķes em pacientes com LMT em um grande centro de trauma. M√©todo: Estudo transversal com 434 pacientes com LMT aguda de 2004 a 2014. Os desfechos foram a frequ√™ncia e caracter√≠stica das complica√ß√Ķes, o tempo de interna√ß√£o (TDI), e fatores associados com seu aumento. Resultados: Incid√™ncia de complica√ß√Ķes foi 82,2%, sendo as mais frequentes: infec√ß√£o do trato urin√°rio (ITU)=64,4%, √ļlcera de press√£o (UP)= 50,6% e pneumonia= 23,7%. Pneumonia, intuba√ß√£o, e ser submetido a qualquer cirurgia para UP foram independentemente associados com aumento do TDI. Conclus√£o: ITUs e UP foram as complica√ß√Ķes mais prevalentes, e devem ser melhor estudadas para melhor aten√ß√£o a LMT. As investiga√ß√Ķes sobre as complica√ß√Ķes na les√£o medular traum√°tica devem ser mandat√≥rias nos centros e unidades dedicadas ao tratamento da Les√£o Medular.There is scarce data about intra-hospital complications in acute traumatic spinal cord injury (TSCI). Objective: To report characteristics of complications in patients with TSCI in a major trauma center. Method: This is a cross-sectional study with 434 patients with acute TSCI from 2004 to 2014. Outcomes were frequency and description of complications, length of hospital stay (LOS), and causes of increased LOS. Results: Patients presented at least 1 complication in 82.2% of the cases: urinary tract infection (UTI) = 64.4%, pressure ulcers (PU) = 50.6%, and pneumonia = 23.7%. Pneumonia, intubation and cases of surgical corrections for PU were independently associated with increased LOS. Conclusion: UTIs and PUs were the most frequent complications. Investigating its causes and consequences is paramount in the care of patients with SCI. Possible reasons for such complications could comprise time, and frequency of repositioning in bed. Investigating intra-hospital complications is paramount in SCI centers

    Randomized controlled clinical trials in orthopedics: difficulties and limitations

    Get PDF
    Os ensaios cl√≠nicos controlados e randomizados (ECCR) s√£o considerados o padr√£o ouro da medicina baseada em evid√™ncias na atualidade, sendo importantes para direcionar a conduta m√©dica atrav√©s de observa√ß√Ķes cient√≠ficas consistentes. Passos como sele√ß√£o dos pacientes, randomiza√ß√£o e cegamento s√£o fundamentais na realiza√ß√£o de um ECCR e apresentam algumas dificuldades extras nos ensaios que envolvem procedimentos cir√ļrgicos, como √© comum na Ortopedia. O objetivo deste artigo √© destacar e discutir algumas dificuldades e eventuais limita√ß√Ķes dos ECCR na √°rea cir√ļrgica.Randomized controlled clinical trials (RCTs) are considered to be the gold standard for evidence-based medicine nowadays, and are important for directing medical practice through consistent scientific observations. Steps such as patient selection, randomization and blinding are fundamental for conducting an RCT, but some additional difficulties are presented in trials that involve surgical procedures, as in common in orthopedics. The aim of this article was to highlight and discuss some difficulties and possible limitations on RCTs within the field of surgery

    Dor miofascial em pacientes com osteoartrose do quadril

    Get PDF
    A osteoartrose (OA) do quadril √© uma doen√ßa de alta preval√™ncia, especialmente nas faixas et√°rias mais avan√ßadas. Seu tratamento por meio da artroplastia tem resultados muito satisfat√≥rios n√£o apenas no que concerne a dor mas tamb√©m em termos de melhora funcional. Contudo, diante da presen√ßa tamb√©m elevada de outras afec√ß√Ķes que complicam o procedimento anest√©sico e o acompanhamento p√≥s-operat√≥rio, o uso de alternativas terap√™uticas menos invasivas √© recomend√°vel, sendo, por vezes, a √ļnica forma restante de tratamento, mesmo que apenas paliativo. A investiga√ß√£o de outras causas de dor e incapacidade nestes pacientes √© uma obriga√ß√£o do m√©dico preocupado com o bemestar destes pacientes. Neste artigo faremos uma breve revis√£o de aspectos cl√≠nicos da osteoartrose do quadril e proporemos uma nova abordagem, tendo em vista a pesquisa de pontos dolorosos relacionados √† s√≠ndrome dolorosa miofascial

    Neurophysiological biomarkers of motor improvement from Constraint-Induced Movement Therapy and Robot-Assisted Therapy in participants with stroke

    Get PDF
    BackgroundThe mechanism of stroke recovery is related to the reorganization of cerebral activity that can be enhanced by rehabilitation therapy. Two well established treatments are Robot-Assisted Therapy (RT) and Constraint-Induced Movement Therapy (CIMT), however, it is unknown whether there is a difference in the neuroplastic changes induced by these therapies, and if the modifications are related to motor improvement. Therefore, this study aims to identify neurophysiological biomarkers related to motor improvement of participants with chronic stroke that received RT or CIMT, and to test whether there is a difference in neuronal changes induced by these two therapies.MethodsThis study included participants with chronic stroke that took part in a pilot experiment to compare CIMT vs. RT. Neurophysiological evaluations were performed with electroencephalography (EEG) and transcranial magnetic stimulation (TMS), pre and post rehabilitation therapy. Motor function was measured by the Wolf Motor Function Test (WMFT) and Fugl-Meyer Assessment Upper Limb (FMA-UL).ResultsTwenty-seven participants with chronic stroke completed the present study [mean age of 58.8‚ÄČyears (SD‚ÄȬĪ‚ÄČ13.6), mean time since stroke of 18.2‚ÄČmonths (SD‚ÄȬĪ‚ÄČ9.6)]. We found that changes in motor threshold (MT) and motor evoked potential (MEP) in the lesioned hemisphere have a positive and negative correlation with WMFT improvement, respectively. The absolute change in alpha peak in the unlesioned hemisphere and the absolute change of the alpha ratio (unlesioned/lesioned hemisphere) is negatively correlated with WMFT improvement. The decrease of EEG power ratio (increase in the lesioned hemisphere and decrease in the unlesioned hemisphere) for high alpha bandwidths is correlated with better improvement in WMFT. The variable ‚Äútype of treatment (RT or CIMT)‚ÄĚ was not significant in the models.ConclusionOur results suggest that distinct treatments (RT and CIMT) have similar neuroplastic mechanisms of recovery. Moreover, motor improvements in participants with chronic stroke are related to decreases of cortical excitability in the lesioned hemisphere measured with TMS. Furthermore, the balance of both EEG power and EEG alpha peak frequency in the lesioned hemisphere is related to motor improvement
    • ‚Ķ
    corecore