Bigger Bursts From Merging Neutron Stars

GRB 990123 may have radiated more than one solar mass equivalent in just its gamma emissions. Though this may be within the upper limit of the binding energy available from neutron stars in the Schwarzschild metric, it is difficult to imagine a process with the required efficiency of conversion to gamma rays. Neutron stars of ~10 solar mass are permitted in the Yilmaz metric. A merger of two neutron stars of maximum mass could release approximately 10 solar mass equivalent binding energy.Comment: 5 pages, 1 figure, submitted to ApJ Letter

Identification of distinct human invariant natural killer T-cell response phenotypes to alpha-galactosylceramide.

Background Human CD1d-restricted, invariant natural killer T cells (iNKT) are a unique class of T lymphocytes that recognise glycolipid antigens such as α-galactosylceramide (αGalCer) and upon T cell receptor (TCR) activation produce both Th1 and Th2 cytokines. iNKT cells expand when cultured in-vitro with αGalCer and interleukin 2 (IL-2) in a CD1d-restricted manner. However, the expansion ratio of human iNKT cells varies between individuals and this has implications for attempts to manipulate this pathway therapeutically. We have studied a panel of twenty five healthy human donors to assess the variability in their in-vitro iNKT cell expansion responses to stimulation with CD1d ligands and investigated some of the factors that may influence this phenomenon. Results Although all donors had comparable numbers of circulating iNKT cells their growth rates in-vitro over 14 days in response to a range of CD1d ligands and IL-2 were highly donor-dependent. Two reproducible donor response patterns of iNKT expansion were seen which we have called 'strong' or 'poor' iNKT responders. Donor response phenotype did not correlate with age, gender, frequency of circulating iNKT, or with the CD1d ligand utilised. Addition of exogenous recombinant human interleukin 4 (IL-4) to 'poor' responder donor cultures significantly increased their iNKT proliferative capacity, but not to levels equivalent to that of 'strong' responder donors. However in 'strong' responder donors, addition of IL-4 to their cultures did not significantly alter the frequency of iNKT cells in the expanded CD3+ population. Conclusion (i) in-vitro expansion of human iNKT cells in response to CD1d ligand activation is highly donor variable, (ii) two reproducible patterns of donor iNKT expansion were observed, which could be classified into 'strong' and 'poor' responder phenotypes, (iii) donor iNKT response phenotypes did not correlate with age, gender, frequency of circulating iNKT cells, or with the CD1d ligand utilised, (iv) addition of IL-4 to 'poor' but not 'strong' responder donor cultures significantly increased their in-vitro iNKT cell expansion to αGalCer

Direct Microlensing-Reverberation Observations of the Intrinsic magnetic Structure of AGN in Different Spectral States: A Tale of Two Quasars

We show how direct microlensing-reverberation analysis performed on two well-known Quasars (Q2237 - The Einstein Cross and Q0957 - The Twin) can be used to observe the inner structure of two quasars which are in significantly different spectral states. These observations allow us to measure the detailed internal structure of quasar Q2237 in a radio quiet high-soft state, and compare it to quasar Q0957 in a radio loud low-hard state. We find that the observed differences in the spectral states of these two quasars can be understood as being due to the location of the inner radii of their accretion disks relative to the co-rotation radii of rotating intrinsically magnetic supermassive compact objects in the centers of these quasars.Comment: 26 page manuscript with 2 tables and 2 figures, submitted to Astronomical Journa

Big Bang nucleosynthesis and physics beyond the Standard Model

The Hubble expansion of galaxies, the 2.73\dK blackbody radiation background and the cosmic abundances of the light elements argue for a hot, dense origin of the universe --- the standard Big Bang cosmology --- and enable its evolution to be traced back fairly reliably to the nucleosynthesis era when the temperature was of \Or(1) MeV corresponding to an expansion age of \Or(1) sec. All particles, known and hypothetical, would have been created at higher temperatures in the early universe and analyses of their possible effects on the abundances of the synthesized elements enable many interesting constraints to be obtained on particle properties. These arguments have usefully complemented laboratory experiments in guiding attempts to extend physics beyond the Standard SU(3)_{\c}{\otimes}SU(2)_{\L}{\otimes}U(1)_{Y} Model, incorporating ideas such as supersymmetry, compositeness and unification. We first present a pedagogical account of relativistic cosmology and primordial nucleosynthesis, discussing both theoretical and observational aspects, and then proceed to examine such constraints in detail, in particular those pertaining to new massless particles and massive unstable particles. Finally, in a section aimed at particle physicists, we illustrate applications of such constraints to models of new physics.Comment: 156 pages LaTeX, including 18 PostScript figures; uses ioplppt.sty, epsf, and personal style file (incl.); Revised and updated to include, e.g. implications of new deuterium observations in primordial clouds; 2-up PostScript version (78 pages) available at ftp://ftp.physics.ox.ac.uk/pub/local/users/sarkar/BBNreview.ps.gz ; to appear in Reports on Progress in Physic