Table_1_Successful treatment of fulminant myocarditis with intra-aortic balloon pump counterpulsation combined with immunoglobulin and glucocorticoid in a young male adult.pdf

BackgroundFulminant myocarditis (FM) is a serious non-specific inflammatory disease of the myocardium. FM tends to occur in adolescents and the course of the disease progresses rapidly. It is prone to cardiogenic shock (CGS) and multiple organ failure (MOF) with high mortality. We report a case of FM with CGS and MOF in a young male who was successfully treated with intra-aortic balloon pump counterpulsation (IABP) combined with intravenous immunoglobulin (IVIG) and glucocorticoid (GC).Case summaryA 21-year-old previously healthy man presented with fever, headache, and chest tightness. He came to the hospital for emergency treatment. The laboratory data showed that the levels of serum cardiac troponin I (cTnI), N-terminal B-type natriuretic peptide (NT-proBNP), myocardial zymogram, and neutrophils increased. Echocardiography showed pericardial effusion and decreased left ventricular systolic function. ECG showed diffuse ST-segment elevation. He was clinically diagnosed with FM and admitted to the intensive care unit for treatment. Within 48 h of admission, the clinical course of the patient deteriorated rapidly, with CGS accompanied by MOF, high atrioventricular block (AVB), and ventricular tachycardia (VT). After using mechanical circulatory support (MCS) therapy with IABP, IVIG, GC, continuous renal replacement therapy (CRRT), and mechanical ventilation complicated with a temporary cardiac pacemaker, he recovered normal cardiac function. He made a full recovery and was discharged home on day 21.DiscussionFor patients with FM, early diagnosis, close monitoring, timely use of MCS devices, and active comprehensive treatment are very important. MCS devices such as IABP can become lifesaving tools for the treatment of FM.</p

Highly Active and Selective Photocatalytic Oxidation of Organosilanes to Silanols

Silanols are ubiquitous building blocks for organic synthesis and material fabrication. To date, a number of stoichiometric and catalytic methods have been developed for the direct oxidation of Si–H to Si–OH bonds. A common challenge in the oxidation of silanes is to combine both catalytic activity and selectivity. Herein, we report a highly active and selective photocatalytic approach for the oxidation of organosilanes to silanols. Using plasmonic Au-TiO2 as a photocatalyst for dimethylphenylsilane oxidation enables complete conversion (>99% yield) and high selectivity (98.3%) with catalytic activity up to 121.8 g g–1. The observed activity substantially exceeds those of most reported homogeneous and heterogeneous catalysts. Silanol synthesis could be achieved under mild conditions in either aqueous or solvent-free conditions and allows the oxidation of a broad scope of sterically hindered hydrosilanes in excellent yield and selectivity. The general concept of photocatalytic synthesis of valuable silanols is further demonstrated by five photocatalysts

Construction of Lewis Pairs for Optimal Enantioresolution via Recognition-Enabled “Chromatographic” ¹⁹F NMR Spectroscopy

Chirality is a ubiquitous phenomenon in nature, serving as a foundation for a variety of life activities on earth. Separation-free methods that rapidly and accurately distinguish chiral analytes in complex systems are highly demanded in fields ranging from drug quality control to the screening of privileged chiral catalysts. However, in situ enantidifferentiation methods possessing resolution and tunability that are comparable to those achieved by chiral high-performance liquid chromatography are rare. Herein, we report a Lewis pair–based system for enantioanalysis via recognition-enabled “chromatographic” 19F NMR spectroscopy. The construction of Lewis pairs renders the detecting system not only enhanced affinity to chiral analytes but also superior and tunable resolving capability. Using this strategy, as many as 16 chiral analytes are simultaneously resolved without need for separation, thus opening new avenues for the development of precise and real-time detection methods that are robust enough for dealing with complex real-world samples

Aurivillius Halide Perovskite: A New Family of Two-Dimensional Materials for Optoelectronic Applications

Layered perovskites have attracted considerable attention in optoelectronic applications because of their excellent electronic properties and stability. In this work, the quasi-2D Aurivillius halide perovskites are investigated using density functional theory. The single-layer Aurivillius perovskite Ba2PbI6 is predicted to have a direct band gap of 1.89 eV, which is close to that of the Ruddlesden–Popper perovskite Cs2PbI4. The electronic structures near the Fermi level are mainly governed by the [PbX6] octahedra, which leads to electronic properties similar to that of Cs2PbI4. Decomposition energies reveal that these Aurivillius perovskites exhibit thermal instability. However, increasing the number of the [PbX6] octahedra layer can enhance the stability and reduce the band gap. Our results indicated that for n ≥ 5, it is possible to synthesize the thermally stable Cl-based Aurivillius perovskite Ba2Csn‑1PbnCl3n+3. Bi- and In-based Aurivillius perovskites are also calculated to evaluate the Pb-free alternatives. These calculations can serve as a theoretical support in exploring novel layered perovskites for optoelectronic applications

Thiosalicylic Acid Modified Graphene Aerogel as Efficient Electrode Material for Ionic Liquid Electrolyte-Based Supercapacitors

Balancing energy density and power density of supercapacitors is highly desired to extend their application range. The development of new electrode materials with efficient electron/ion migration channels and large surface area accessible by the ionic liquid (IL) electrolyte with high stable potential window is a critical way to construct the high-performances of supercapacitors. In this work, a thiosalicylic acid modified graphene aerogel (TGA) was prepared by hydrothermal treatment of a graphene oxide precursor using thiosalicylic acid (TSA) as reductant, sulfur-dopant, and modifier. As-prepared TGA material has hierarchically porous texture with wide pore size distribution range and large accessible surface area by IL electrolytes, which is beneficial to the rapid diffusion and adsorption of IL electrolyte ions with larger ion sizes and high viscosity. Therefore, the TGA material possesses high specific capacitance and rate capability. Using 1-butyl-3-methylimidazolium bis­[(trifluoromethyl)­sulfonyl]­imide ([Bmim]­[Tf2N]) IL electrolyte, the assembled symmetric TGA-based supercapacitor can deliver energy densities of 115–28 Wh kg–1 within power densities of 946–11586 W kg–1. The current work provides a feasible avenue to accomplish the balance between energy density and power density of supercapacitors via the design and synthesis of hierarchically porous graphene aerogels containing doped-heteroatoms and matching with IL electrolyte

Synergistic mediation of polysulfide immobilization and conversion by a catalytic and dual-adsorptive system for high performance lithium-sulfur batteries

Although various inorganic particles have been confirmed as effective trappers to restrict the shuttle effect of lithium polysulfides (LiPSs) in lithium-sulfur batteries (LSB), the further reduction of LiPSs is impeded due to their low conductivity. This process results in sluggish redox kinetics at the interface of cathode/electrolyte and escaped LiPSs to electrolytes during long-term cycling. Herein, by advantageous functional integration of immobilization and conversion capability for LiPSs, a 3D aerogel with the composition of Co@CoO@N-doped carbon@graphene (Co@CoO@N-C/rGO) is designed and prepared. The dual-shells of N-C and polar CoO enable the strong chemical adsorption towards LiPSs through pyridinic – N-Li-bond and Co···S coordination, respectively. And the conductive Co core acts as a “scissor”, which catalyzes the transformation of adsorbed LiPSs into low-order ones, thus accelerating the kinetics of the liquid–solid nucleation and growth of Li S. Moreover, the matrix of rGO serves as electrical networks, significantly promoting the transfer of electrons to the redox-active sites. Based on these synergetic effects, the LSB using Co@CoO@N-C/rGO modified separators exhibits outstanding electrochemical performance. For example, even at a rate of 1C, the cell still delivers a stable capacity of 555.4 mAh g after 500 cycles for a pure sulfur electrode. Moreover, the relevant kinetic mechanisms including in situ Raman test are expounded in detail. 2 −

Constraining and Tuning the Coordination Geometry of a Lanthanide Ion in Metal–Organic Frameworks: Approach toward a Single-Molecule Magnet

It is available to constrain and tune the coordination geometries around lanthanide ions in metal–organic frameworks (MOFs) for the study of single-molecule-magnet (SMM) behavior. A series of Dy^III-MOFs are synthesized via a solvothermal method by using furan-2,5-dicarboxylic acid (H₂FDA) as the ligand. {[Dy₂(FDA)₃(DMF)₂]·1.5DMF}_<i>n</i> (<b>1</b>) and [Dy₂(FDA)₃(DMF)₂(CH₃OH)]_<i>n</i> (<b>2</b>) show similar three-dimensional structures, but the coordination geometries around the dysprosium­(III) ions in <b>1</b> and <b>2</b> exhibit different deviations from ideal square antiprism (<i>D</i>_4<i>d</i> symmetry) because of the coordinated solvent molecules. Slow relaxation of the magnetization can be observed for both complexes, indicative of SMM behavior. The effective energy barriers for <b>1</b> and <b>2</b> can be obtained from alternating-current susceptibility measurements by applying an external 2000 Oe direct-current field. MOF <b>2</b> possesses a less distorted <i>D</i>_4<i>d</i> coordination sphere and gives a higher effective energy barrier (<i>U</i>_eff) than that of MOF <b>1</b>. Their diamagnetic Y^III-diluted samples <b>1@Y</b> and <b>2@Y</b> exhibit similar relationships between the geometries and <i>U</i>_eff values, demonstrating that the magnetization relaxation is mainly from the symmetry-related single-ion behavior

Competitive Ratiometric Aptasensing with Core-Internal Standard-Shell Structure Based on Surface-Enhanced Raman Scattering

Reproducibility and stability are important indicators for the evaluation of quantitative sensing methods based on surface-enhanced Raman scattering (SERS) technology. Developing a SERS substrate with self-calibration capabilities is vital for effectively quantifying targets. In this work, a competitive ratiometric SERS aptasensor was developed. 4-Aminothiophenol as an internal standard (IS) was embedded in the substrate followed by gradually loading with the aptamer and methylene blue functionalizing of the complementary sequences of the aptamer (MB-cDNA). Recognition and binding of the target to the aptamer resulted in the shedding of MB-cDNA after magnetic separation reducing the SERS signal of MB, allowing for the ratiometric determination of the target based on the constant intensity from the IS. For the selective detection of okadaic acid (OA), a good negative correlation was achieved between the SERS ratiometric intensity and OA concentration in the range of 0.5–100 ng/mL. The magnetic separation strategy effectively simplifies the production steps of the aptasensor, and the ratiometric strategy effectively improved the reproducibility and stability of the OA sensing. This ratiometric aptasensor has been successfully employed to detect OA in food and environmental samples and is expected to be extended to detect other targets

Table1_Modification of polypropylene mesh by titanium compound: An in Vivo and in Vitro study.docx

Objective: Previous basic studies on the use of titanized polypropylene meshes in abdominal external hernia repair are not only limited, but also highly controversial. This study aims to investigate the modification effect of titanium compounds on polypropylene materials and compare the performance of two kinds of meshes both in vivo and in vitro.Methods: Human peritoneal mesothelial cells (HMrSV5), human epidermal fibroblasts (HSF), and human monocytic cells (THP-1) were cultured in vitro to simulate the abdominal external hernia environment. Titanized polypropylene meshes (Ti) and polypropylene mesh (Non-Ti) were co-cultured with the cells respectively. The effects of titanium compounds on cell growth were determined by cell activity and apoptosis, and the growth of cells on the mesh surface was assessed using a scanning electron microscope and a confocal microscope. In vivo experiments, different sizes titanized polypropylene meshes and polypropylene meshes were placed between the external oblique abdominal muscle and the internal oblique abdominal muscle, the parietal peritoneum, the serous layer of the descending colon, and the underside of the femoral nerve in rabbits. The effects of titanium compounds were evaluated by observing the anti-adhesion, anti-contraction, anti-fibrotic properties, and effects on nerves of the mesh.Results: Titanium compounds effectively reduced the effects of polypropylene material on cell growth, and improved the fixation and adhesion of HMrSV5, HSF and THP-1 (M0) on the surface of titanized polypropylene meshes. Furthermore, titanium compounds improved the adhesion, contraction and fibrosis of polypropylene material, as well as reduced nerve damage. This improvement demonstrated a regular trend with the type of titanized polypropylene meshes.Conclusion: The titanium compounds improved the biocompatibility of the polypropylene material, which was conducive to the fixation and adhesion of cells on the surface of the meshes, and alleviated the adhesion and contraction of the meshes, and the degree of tissue fibrosis, as well as the influence on nerves.</p

Turn-On Fluoresence Sensor for Hg²⁺ in Food Based on FRET between Aptamers-Functionalized Upconversion Nanoparticles and Gold Nanoparticles

In this study, a turn-on nanosensor for detecting Hg²⁺ was developed based on the fluorescence resonance energy transfer (FRET) between long-strand aptamers-functionalized upconversion nanoparticles (UCNPs) and short-strand aptamers-functionalized gold nanoparticles (GNPs). In the absence of Hg²⁺, FRET between UCNPs and GNPs occurred because of the specific matching between two aptamers, resulting in the fluorescence quenching of UCNPs. In the presence of Hg²⁺, long-stranded aptamers fold back into a hairpin structure due to the stable binding interactions between Hg²⁺ and thymine, leading to the release of GNPs from UCNPs, resulting in the quenched fluorescence restoration. Under the optimized conditions, the nanosensor achieved a linear detection range of 0.2–20 μM and a low detection limit (LOD) of 60 nM. Meanwhile, it showed good selectivity and has been applied to detecting Hg²⁺ in tap water and milk samples with good precision