Additional file 1: Table S1. of Event-related potentials elicited by the Deutsch “high-low” word illusion in the patients with first-episode schizophrenia with auditory hallucinations

Pearson correlations between ERP latencies and amplitudes and PANSS scores in schizophrenia (n = 16). (DOCX 26 kb

Morphology and characterization of BM-MSCs.

<p>(A, B): The morphology of BM-MSCs of passage 5 (×100 magnification [A] and ×200 magnification [B]). The BM-MSCs have a fibroblast-like, spindle-shaped morphology. (C–F): Immunophenotype of BM-MSCs. BM-MSCs of passage 5 were marked with antibodies specific for positive antigen (CD 90 [C] and CD 29 [F]) or negative controls (CD45 [D] and CD11b/c [E]), and analyzed by flow cytometry.</p

Changes in Hepatic Copper Content of LEC Rats as a Function of Time after MSC^ATP7B Transplantation (µg/g dry weight tissue).

<p>IRP: Ischemia Reperfusion, RT: radiation.</p><p>*<i>p</i><0.05, compared with the saline group.</p>&<p><i>p</i><0.05, compared with IRP and RT groups, respectively.</p><p>Changes in Hepatic Copper Content of LEC Rats as a Function of Time after MSC^ATP7B Transplantation (µg/g dry weight tissue).</p

Serum Ceruloplasmin Levels in LEC Rats 4, 12, and 24 weeks after MSCs^ATP7B Transplantation (mg/dL).

<p>IRP: Ischemia Reperfusion, RT: radiation.</p><p>*<i>p</i><0.05, compared with the saline group.</p>&<p><i>p</i><0.05, compared with IRP group and RT group, respectively.</p><p>Serum Ceruloplasmin Levels in LEC Rats 4, 12, and 24 weeks after MSCs^ATP7B Transplantation (mg/dL).</p

Transfection efficacy, expression of ATP7B post-transfection and post-transplantation.

<p>(A) Transfection efficacy of pRRL.PPT.SF.ATP7B.i2GFPBsd.pre in BM-MSCs. (B) Transfection efficacy of pRRL.PPT.SF.i2GFPpre in BM-MSCs. Transfected cells were observed under both a fluorescence microscope and a regular microscope (×100); (C) Expression of ATP7B in BM-MSCs post-transfection assessed by Western Blot. (D) Expression of ATP7B in each group at each time-point following transplantation <i>in vivo</i>. ^*<i>p</i><0.05 compared with the saline group, ^&<i>p</i><0.05 compared with IRP and RT group, respectively.</p

Effect of BM-MSCs on serum biomarkers.

<p>Values are expressed as mean ± SD. For ALT and AST levels at each time point, IRP, RT, and IRP-plus-RT groups are compared with the saline group, respectively; IRP and RT groups are also compared with IRP-plus-RT group, respectively. ^*<i>p</i><0.05, ^**<i>p</i><0.01.</p

Hematoxylin and eosin and Masson's trichrome staining of liver sections 24 weeks post-transplantation.

<p>A. H&E staining, (a, b): Typical histological finding of cholangiocarcinoma seen in the liver of saline and MSCs^ATP7B groups. (c–e): Livers of IRP, RT, and IRP-plus-RT rats, respectively. The typical histological finding of cholangiocarcinoma is absent, but the histological finding of chronic hepatitis is present. Enlarged nuclei and fatty changes are visible in some of the hepatocytes; lymphocytes are irregularly distributed among hepatocytes. (C: cholangiocarcinoma; H: regenerated hepatocytes; L: lymphocytes; F: fine fatty droplets); B. MT staining. C. Quantitation of MT staining. The liver fibrosis of IRP, RT, and IRP-plus-RT groups are compared with the saline group, respectively; IRP and RT groups are also compared with IRP-plus-RT group, respectively. ^**<i>p</i><0.01.</p

Migration and population of transplanted BM-MSCs <i>in vivo</i>.

<p>Expression of CK-18 in GFP labeled BM-MSCs engrafted in liver tissues 4 weeks after transplantation; detection by immunofluorescence histochemistry. (DAPI, 4′,6-diamidino-2-phenylindole). The collected figure illustrates hepatocytes differentiated from transplanted MSCs^ATP7B: (a) IRP-plus-RT group, (b) RT group, (c) IRP group, (d) MSCs^ATP7B group, (e) saline group.</p