New aristolochic acid and other chemical constituents of <i>Aristolochia maurorum</i> growing wild in Jordan

<p>Investigation of the chemical constituents of <i>Aristolochia maurorum</i> growing wild in Jordan resulted in the isolation and characterisation of one new compound in addition to 19 known compounds. The new compound was identified as aristolochic acid II alanine amide (<b>14</b>). The other known compounds were the following: palmitic acid (<b>1</b>), β-sitosterol (<b>2</b>), <i>E</i>-ethyl-<i>p</i>-coumarate (<b>3</b>), <i>Z</i>-ethyl-<i>p</i>-coumarate (<b>4</b>), aristolochic acid IV methyl ester (<b>5</b>), aristolactam I (<b>6</b>), loliolide (<b>7</b>), (+)-dehydrovomifoliol (<b>8</b>), glycerol-1-palmitate (<b>9</b>), aristolochic acid I (<b>10</b>), <i>E</i>-<i>p</i>-coumaric acid (<b>11</b>), <i>E</i>-N-coumaroyltyramine (<b>12</b>), β-sitosteryl glucoside (<b>13</b>), aristolochic acid IV (<b>15</b>), aristolochic acid III (<b>16</b>), esculetin (<b>17</b>), uracil (<b>18</b>), shepherdine (<b>19</b>) and adenosine (<b>20</b>). The isolated compounds were characterised by different spectroscopic methods including NMR (1D and 2D), UV, IR and HRESIMS.</p

Chemical constituents of the aerial parts of <i>Salvia judaica</i> Boiss. from Jordan

Investigation of the chemical constituents of Salvia judaica growing wild in Jordan led to the isolation and identification of 15 known compounds. These included: luteolin-3′-methyl ether (1), indole-3-carboxyaldehyde (2), p-hydroxybenzaldehyde (3), tricin (4), apigenin (5), methyl isoferuloyl-7-(3,4-dihydroxyphenyl) lactate (6), methyl rosmarinate (7), rosmarinic acid (8), salvigenin (9), β-sitosterol (10), 3β, 28-dihydroxyurs-12-ene (11), cirsilineol (12), 2,3-dihydroxyurs-12-en-28-oic acid (13), β-sitosteryl glucoside (14), and tormentic acid (15). Compounds 6 and 7 exhibited strong radical scavenging and chelating activities as compared to α-tocopherol and ascorbic acid, compound 7 showed a 2-fold greater antioxidant activity as compared to compound 6. Furthermore, low doses of compounds 6 and 7 were able to inhibit the growth of leukemic (HL-60, Jurkat, K562 and CCRF-SB) and solid tumor cells (MCF-7, MDA-MB-231 and Caco-2). Compound 7 showed a ca. 3–4-fold stronger cytotoxicity against the tested cells as compared to compound 6.</p