Electric Tuning of Vortex Ratchet Effect in NbSe₂

Inversion symmetry breaking has played an important role in recent discoveries of nonreciprocal charge transport. Niobium diselenide, for example, lacks an inversion center in the monolayer form and can host prominent nonreciprocal transport property. Here, however, we observe a nonreciprocal transport signal in the second-harmonic channel of bulk-like NbSe2, in which inversion symmetry of the lattice seems preserved. The second-harmonic signal occurs along different in-plane current orientations and appears not only in the vortex-liquid regime but also even in the superconducting fluctuation regime without an applied magnetic field. By adding a direct current (DC) bias, we quantify the symmetry breaking effect in the vortex-liquid regime. The DC bias also suggests that the rectification effect at the contacts may account for the seemingly nonreciprocal transport at zero magnetic field. Our results demonstrate that DC biasing is a useful knob for addressing nonreciprocal charge transport in a wide range of materials

DataSheet1_Diverse Inter-Annual Variations of Winter Siberian High and Link With Eurasian Snow in Observation and BCC-CSM2-MR Coupled Model Simulation.PDF

An observational study illustrates that three distinct modes of winter Siberian high variability exist in observations at the inter-annual time scale. In this paper, we compare the connection between these diverse Siberian high variation modes with pre-autumn and simultaneous Eurasian snow cover in an observation and BCC-CSM2-MR coupled climate model run under pre-industrial conditions from the CMIP6 project. Our analyses indicate that the inter-annual variation of observed Siberian high modes do have a connection with pre-autumn and simultaneous Eurasian snow cover anomalies, but the BCC-CSM2-MR coupled climate model does not capture the observed diverse Eurasian snow–Siberian high relationships well. The BCC-CSM2-MR coupled climate model can partly reproduce the observed Siberian high variation modes, but fail to capture the spatial distribution and statistics of boreal fall and winter Eurasian snowpack, which is a key facet of simulated diverse Siberian high variability irrespective of the influence of Eurasian snow cover.</p

Image1_Functional inference of long non-coding RNAs through exploration of highly conserved regions.JPEG

Background: Long non-coding RNAs (lncRNAs), which are generally less functionally characterized or less annotated, evolve more rapidly than mRNAs and substantially possess fewer sequence conservation patterns than protein-coding genes across divergent species. People assume that the functional inference could be conducted on the evolutionarily conserved long non-coding RNAs as they are most likely to be functional. In the past decades, substantial progress has been made in discussions on the evolutionary conservation of non-coding genomic regions from multiple perspectives. However, understanding their conservation and the functions associated with sequence conservation in relation to further corresponding phenotypic variability or disorders still remains incomplete.Results: Accordingly, we determined a highly conserved region (HCR) to verify the sequence conservation among long non-coding RNAs and systematically profiled homologous long non-coding RNA clusters in humans and mice based on the detection of highly conserved regions. Moreover, according to homolog clustering, we explored the potential function inference via highly conserved regions on representative long non-coding RNAs. On lncRNA XACT, we investigated the potential functional competence between XACT and lncRNA XIST by recruiting miRNA-29a, regulating the downstream target genes. In addition, on lncRNA LINC00461, we examined the interaction relationship between LINC00461 and SND1. This interaction or association may be perturbed during the progression of glioma. In addition, we have constructed a website with user-friendly web interfaces for searching, analyzing, and downloading to present the homologous clusters of humans and mice.Conclusion: Collectively, homolog clustering via the highly conserved region definition and detection on long non-coding RNAs, as well as the functional explorations on representative sequences in our research, would provide new evidence for the potential function of long non-coding RNAs. Our results on the remarkable roles of long non-coding RNAs would presumably provide a new theoretical basis and candidate diagnostic indicators for tumors.</p

Image2_Functional inference of long non-coding RNAs through exploration of highly conserved regions.JPEG

Background: Long non-coding RNAs (lncRNAs), which are generally less functionally characterized or less annotated, evolve more rapidly than mRNAs and substantially possess fewer sequence conservation patterns than protein-coding genes across divergent species. People assume that the functional inference could be conducted on the evolutionarily conserved long non-coding RNAs as they are most likely to be functional. In the past decades, substantial progress has been made in discussions on the evolutionary conservation of non-coding genomic regions from multiple perspectives. However, understanding their conservation and the functions associated with sequence conservation in relation to further corresponding phenotypic variability or disorders still remains incomplete.Results: Accordingly, we determined a highly conserved region (HCR) to verify the sequence conservation among long non-coding RNAs and systematically profiled homologous long non-coding RNA clusters in humans and mice based on the detection of highly conserved regions. Moreover, according to homolog clustering, we explored the potential function inference via highly conserved regions on representative long non-coding RNAs. On lncRNA XACT, we investigated the potential functional competence between XACT and lncRNA XIST by recruiting miRNA-29a, regulating the downstream target genes. In addition, on lncRNA LINC00461, we examined the interaction relationship between LINC00461 and SND1. This interaction or association may be perturbed during the progression of glioma. In addition, we have constructed a website with user-friendly web interfaces for searching, analyzing, and downloading to present the homologous clusters of humans and mice.Conclusion: Collectively, homolog clustering via the highly conserved region definition and detection on long non-coding RNAs, as well as the functional explorations on representative sequences in our research, would provide new evidence for the potential function of long non-coding RNAs. Our results on the remarkable roles of long non-coding RNAs would presumably provide a new theoretical basis and candidate diagnostic indicators for tumors.</p

Laser-Induced Graphene-based Flexible Substrate with Photothermal Conversion and Photoresponse Performance on Polyimide Film

Graphene-based flexible electronic devices are widely used in photoelectric components and photodetectors. However, it remains a huge challenge to fabricate graphene-based flexible devices efficiently and economically. Compared with the flexible electronic devices made by combining the flexible film with metal and semiconductor materials, the graphene-based flexible substrate (GFS) can be efficiently and conveniently induced by laser direct writing on the flexible film. In this paper, the GFS with a resistance of as low as 15 Ω was successfully induced by CO2 laser on a polyimide (PI) film in one step, and the GFS surface covered with carbon nanoparticles (GFSC) with a resistance of 25 Ω was further induced by femtosecond (fs) laser reprocessing. Benefiting from the laser-induced porous graphene structure, the absorptivity of GFS is up to 90% in the wavelength range of 200–2000 nm. The formation of carbon nanoparticles on the GFSC surface further improves the absorptivity to 97.5% in a wide spectral range. Under white light irradiation of 1 sun, the surface temperature of GFS reaches 65.7 °C and that of GFSC is up to 70.8 °C within 2 min. Under the irradiation of a light-emitting diode (LED) with a central wavelength of 365 nm, the highest photoresponsivity of GFS and GFSC was 8.8 and 1.3 mA/W, respectively. The response time and recovery time of GFS are 8 and 7.3 s, and those of GFSC are 8.3 and 6.7 s, respectively. Importantly, GFSC has a more stable photoresponse performance due to the better electron capture and transfer capability of carbon nanoparticles. It is believed that GFS and GFSC have great application potential in flexible photodetectors and sensors

Table1_Functional inference of long non-coding RNAs through exploration of highly conserved regions.XLSX

Background: Long non-coding RNAs (lncRNAs), which are generally less functionally characterized or less annotated, evolve more rapidly than mRNAs and substantially possess fewer sequence conservation patterns than protein-coding genes across divergent species. People assume that the functional inference could be conducted on the evolutionarily conserved long non-coding RNAs as they are most likely to be functional. In the past decades, substantial progress has been made in discussions on the evolutionary conservation of non-coding genomic regions from multiple perspectives. However, understanding their conservation and the functions associated with sequence conservation in relation to further corresponding phenotypic variability or disorders still remains incomplete.Results: Accordingly, we determined a highly conserved region (HCR) to verify the sequence conservation among long non-coding RNAs and systematically profiled homologous long non-coding RNA clusters in humans and mice based on the detection of highly conserved regions. Moreover, according to homolog clustering, we explored the potential function inference via highly conserved regions on representative long non-coding RNAs. On lncRNA XACT, we investigated the potential functional competence between XACT and lncRNA XIST by recruiting miRNA-29a, regulating the downstream target genes. In addition, on lncRNA LINC00461, we examined the interaction relationship between LINC00461 and SND1. This interaction or association may be perturbed during the progression of glioma. In addition, we have constructed a website with user-friendly web interfaces for searching, analyzing, and downloading to present the homologous clusters of humans and mice.Conclusion: Collectively, homolog clustering via the highly conserved region definition and detection on long non-coding RNAs, as well as the functional explorations on representative sequences in our research, would provide new evidence for the potential function of long non-coding RNAs. Our results on the remarkable roles of long non-coding RNAs would presumably provide a new theoretical basis and candidate diagnostic indicators for tumors.</p

Comparison of PCR and serum agglutination assays for differentiating the serotypes of APEC isolates and clinical infected samples.

<p>Comparison of PCR and serum agglutination assays for differentiating the serotypes of APEC isolates and clinical infected samples.</p

Sensitivity analysis of the allele-specific PCR assay.

<p>(<b>A</b>) <b>Sensitivity analysis using the bacterial genomic DNA.</b> The detection limit was determined as 10 pg of bacterial DNA for <i>E. coli</i> serotypes O2 and O18 strains, and 500 pg of bacterial DNA for <i>E. coli</i> serotypes O1 and O78 strains, respectively. (<b>B</b>) <b>Sensitivity analysis using the bacterial culture.</b> The detection limit was determined as 10 CFUs of <i>E. coli</i> serotypes O2 and O18 strains, and 1,000 CFUs of <i>E. coli</i> serotypes O1 and O78 strains, respectively. Lane M: DL2000 Marker.</p

The <i>rfb</i> gene clusters of <i>E. coli</i> serotypes O1, O2, O18 and O78 strains.

<p>The black arrows correspond to <i>gnd</i> and <i>galF</i> genes. Grey arrows correspond to <i>rfb</i> gene cluster and the gene names are <i>italic</i> indicated. The length of <i>rfb</i> gene cluster was also shown. In the PCR reaction system, the universal forward primer was used for all the sero-typing amplification with specific reverse primers. The bold lines below the <i>gnd</i> gene indicate the size of the PCR products for different <i>E. coli</i> serotype strains, which allow the differentiation of the O types. Primers and their locations were also indicated.</p

The product profiles of <i>E. coli</i> serotypes O1, O2, O18 and O78 strains amplified using the allele-specific PCR.

<p>Lane M: DL2000 DNA Marker; O1, O2, O18 and O78 represent PCR products for O1, O2, O18 and O78 strains respectively. Lane 1: APEC O1 strain; Lane 2: APEC strain DE47; Lane 3: APEC strain DE14; Lane 4: APEC strain DE17; Lane 5: APEC strain RS218; Lane 6: APEC strain CE66; Lane 7: APEC strain DE48; Lane 8: APEC strain DE65; Lane 9: Negative control.</p