Distribution of the signal scores in positive and negative datasets.

<p>Distribution of the signal scores in positive and negative datasets.</p

The performances of pre-miRNA prediction.

<p>The performances of pre-miRNA prediction.</p

Quantitative distribution of miRNA strands in positive training dataset.

<p>Quantitative distribution of miRNA strands in positive training dataset.</p

Illustration of the construction of the stem-bulge-gap notation.

<p>In the stem-bulge-gap notation at the bottom line, the symbols of ‘|’, ‘!’ and ‘:’ represent respectively the base pair of ‘CG’, ‘AU’ and ‘GU’, the symbols of ‘o’, ‘x’ and ‘-’ represent respectively the loop, bulge and gap. In the asymmetric bulges, the symmetric part is indicated with ‘x’ and the asymmetric part with ‘-’.</p

Receiver Operating Characteristic Curve of FOMmiR predictor.

<p>Receiver Operating Characteristic Curve of FOMmiR predictor.</p

Distribution of distances between the real and predicted mature miRNA region.

<p>Distribution of distances between the real and predicted mature miRNA region.</p

Salen-Based Chiral Fluorescence Polymer Sensor for Enantioselective Recognition of α-Hydroxyl Carboxylic Acids

(<i>R</i>,<i>R</i>)-Salen-based chiral polymer <b>P-1</b> was synthesized by the polymerization of 5,5′-((2,5-dibutoxy-1,4-phenylene)­bis­(ethyne-2,1-diyl))­bis­(2-hydroxy-3-(piperidin-1-ylmethyl) benzaldehyde (<b>M-1</b>) with (1<i>R</i>,2<i>R</i>)-cyclohexane-1,2-diamine (<b>M-2</b>) via nucleophilic addition– elimination reaction, and (<i>R</i>,<i>R</i>)-salan-based polymer <b>P-2</b> could be obtained by the reduction reaction of <b>P-1</b> with NaBH₄. (<i>R</i>,<i>R</i>)-Salen-based chiral polymer <b>P-1</b> can exhibit greater fluorescence enhancement response toward (l)-α-hydroxyl carboxylic acids, and the value of enantiomeric fluorescence difference ratio (<i>ef</i>) can reach as high as 8.41 for mandelic acid and 6.55 for lactic acid. On the contrary, (<i>R</i>,<i>R</i>)-salan-based chiral polymer <b>P-2</b> shows obvious fluorescence quenching response toward α-hydroxyl carboxylic acids. Most importantly, (<i>R</i>,<i>R</i>)-salen-based polymer <b>P-1</b> can display bright blue fluorescence color change in the presence of (l)-α-hydroxyl carboxylic acids under a commercially available UV lamp, which can be clearly observed by the naked eyes

<i>In Situ</i> Generated 1:1 Zn(II)-Containing Polymer Complex Sensor for Highly Enantioselective Recognition of N‑Boc-Protected Alanine

A novel chiral (<i>S</i>)-BINAM-based fluorescence polymer sensor was designed and synthesized by the polymerization of 5,5′-((2,5-dioctyloxy-1,4-phenylene)­bis­(ethyne-2,1-diyl)­bis­(2-hydroxy-3-(piperidin-1-ylmethyl)­benzaldehyde (<b>M-1</b>) with (<i>S</i>)-2,2′-binaphthyldiamine (<i>S</i>-<b>BINAM</b>,<b> M-2</b>) via Schiff’s base formation. The resulting chiral polymer sensor shows very weak fluorescence but exhibits the obvious fluorescence enhancement response toward Zn²⁺. The <i>in situ</i> generated 1:1 Zn­(II)-containing complex of chiral polymer can serve as a fluorescence sensor for highly enantioselective recognition of N-Boc-protected alanine, and the value of enantiomeric fluorescence difference ratio (<i>ef</i>) can reach as high as 6.90. This is the first report on the <i>in situ</i> generated chiral polymer complex used as a fluorescence sensor for highly enantioselective recognition of N-Boc-protected alanine

Enantioselective Aerobic Oxidative C(sp³)–H Olefination of Amines via Cooperative Photoredox and Asymmetric Catalysis

A cooperative photoredox and asymmetric catalysis for the enantioselective aerobic oxidative C­(sp³)–H olefination of tetrahydro-β-carbolines (THCs) is reported. This method, which is also effective for tetrahydroisoquinolines (THIQs), features a triple-catalyst strategy, involving a dicyanopyrazine-derived chromophore (DPZ) as the metal-free photoredox catalyst, a chiral Lewis base catalyst, and an inorganic salt cocatalyst. The current protocol provides straightforward access to a series of valuable α-substituted THCs and THIQs in high yields with excellent regio- and enantioselectivities (up to 95% ee)

Enantioselective Aerobic Oxidative C(sp³)–H Olefination of Amines via Cooperative Photoredox and Asymmetric Catalysis

A cooperative photoredox and asymmetric catalysis for the enantioselective aerobic oxidative C­(sp³)–H olefination of tetrahydro-β-carbolines (THCs) is reported. This method, which is also effective for tetrahydroisoquinolines (THIQs), features a triple-catalyst strategy, involving a dicyanopyrazine-derived chromophore (DPZ) as the metal-free photoredox catalyst, a chiral Lewis base catalyst, and an inorganic salt cocatalyst. The current protocol provides straightforward access to a series of valuable α-substituted THCs and THIQs in high yields with excellent regio- and enantioselectivities (up to 95% ee)