(A) Lymphocytes present as part of oCPI-related CD.

<p>(B) These lymphocytes express PAX5 consistent with B cells. (C) Immunostaining for markers of immature B cells, including TdT as shown here, are negative. All original magnifications 400x.</p

STREGA checklist.

(DOCX)</p

Characteristics of participants of European ancestry with available genotype data in GENOA.

Characteristics of participants of European ancestry with available genotype data in GENOA.</p

Appendix.

(DOCX)</p

Unsupervised hierarchical clustering, using the 1446 probes with suggestive differential expression (P-value < 0.05) between oCPI samples and controls, demonstrates complete separation of the two groups.

<p>Unsupervised hierarchical clustering, using the 1446 probes with suggestive differential expression (P-value < 0.05) between oCPI samples and controls, demonstrates complete separation of the two groups.</p

Proportions of IgA, IgM, and IgG expressing plasma cells in oCPI-related CD compared to isolated CD.

<p>Error bars represent the 95% confidence interval of the mean.</p

RNA transcripts significantly associated with oCPI.

<p>14 differentially expressed transcripts were identified using linear models (FDR P-value<0.05). A positive fold change indicates increased expression in oCPI samples as compared to controls.</p

Immunohistochemical subtyping of oCPI placenta demonstrates an IgG, IgA, and IgM expressing plasma cells (top row, original magnification 200x).

<p>In cases of isolated chronic deciduitis (chronic deciduitis without histological evidence of VUE and chronic chorioamnionitis), IgG-positive plasma cells predominate, IgM-positive plasma cells are rare, and IgA-positive plasma cells are not seen (bottom row, original magnification 200x).</p

CYP2B6 SNPs and associated outcomes.

CYP2B6 SNPs and associated outcomes.</p

OPRM1 SNPs and associated outcomes.

OPRM1 SNPs and associated outcomes.</p