Deactivation of airborne bacteria, fungi, and viruses by microwave absorption material Fe₃O₄@SiCcf

This study aims to provide a comprehensive summary of the inactivation of airborne Escherichia coli [(E. coli), a gram-negative bacterium], Bacillus subtilis [(B. subtilis), a gram-positive bacterium], MS2 (a bacteriophage) virus, and Aspergillus versicolor [(A. versicolor), a fungus] with kinetic analysis utilizing microwave irradiation based on absorption material. The capacity of a microwave-absorbing material Fe3O4@SiC ceramic foam (Fe3O4@SiCcf) to inactivate bioaerosols when subjected to microwave (MW) irradiation (2450MHz) for 25 seconds at various output powers (750, 550, 350, and 150W) was determined. The airborne MS2 decreased by 4.5 logs at the microwave (MW) input energy density of 7.2 × 103 kJ/m3, while that for E. coli was at around 4.4 logs, and that for B. subtilis was at 4.3 logs. The activation energy (Ea) applied was 13.2 kJ/mol (E. coli), 14.6 kJ/mol (B. subtilis), and that for MS2 virus was 9.6 kJ/mol. By contrast, this study has shown that A. versicolor log inactivation efficiency was lower and Ea was higher than others, which were 3.6 logs and 16.7 kJ/mol, respectively. In addition, MW - Fe3O4@SiCcf improved the inactivation efficiency of airborne microorganisms significantly compared with no absorbing material. Through the comparative analysis of energy consumption, the rate of constant airborne inactivation through MW irradiation is higher than UV and Fenton. However, the energy efficacy per MW irradiation order is lower. In summary, Fe3O4@SiCcf ceramic form is an energy-efficient material for inactivating airborne microorganisms under MW irradiation.</p

Achieving Adjustable Multifunction Based on Host–Guest Interaction-Manipulated Reversible Molecular Conformational Switching

Small molecules that are capable of toggling between multiple and definite conformational states under external stimuli have great potential for use in molecular switches or sensors. However, currently developed regulation approaches for these switchable molecules mostly involve covalent bond-breaking/reforming processes, thereby inevitably producing byproducts or causing fatigue accumulation. Herein, we report a simple but successful model whose molecular conformation can be precisely manipulated between stretched and folded forms by employing host–guest interactions with rigid macrocycles, thus avoiding possible side reactions and fatigue accumulation and possessing excellent reversibility. Moreover, the conformation states of this molecule can be visualized and identified by luminous readout, endowing it with real-time self-reporting features. Furthermore, this controllable and reversible conformational conversion is accompanied by various valuable functions, including controllable multicolor emission; ratiometric fluorescent thermosensing with high temperature resolution, excellent reversibility, lock/unlock switching, and especially linear detection range tunability; and in addition real-time intracellular temperature sensing and imaging, disclosing the intriguing microscopic “conformation–function” relationship based on a single molecule

Additional file 1 of GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer

Additional file 1. Figure S1. Expression of GPRC5D in resectable and advanced tumors. Figure S2. Correlation between GPRC5D expression and (A) IPS and (B) immunomodulators. Figure S3. Expression of GPRC5D in tumors from responders and non-responders in other cancer types. Table S1. The baseline clinic-pathological features of two cohorts

Additional file 1 of Exploring the causal relationship between immune cells and idiopathic pulmonary fibrosis: a bi-directional Mendelian randomization study

Supplementary Material 1

Unlocking Multicolor Emissions in the Crystalline State through Dimerization and Configurational Transformation of a Single Fluorophore

Multicolor luminescent materials with tunable properties hold great promise for a wide range of applications in materials science. Unfortunately, the conventional approach to achieving multicolor emissions by blending multiple types of fluorophores is hindered by limitations, notably, spectral instability, aggregation-caused quenching, and energy transfer. The pursuit of multicolor emissions from a single type of fluorophore in the solid state has, until now, remained a formidable challenge. In this study, we have introduced N,N′-diphenyl dihydrodibenzo[a,c]-phenazines (DPAC), augmented with two o-carboranyl units, to create a novel fluorophore CbDPAC. The CbDPAC crystal exhibits three distinct emission bands peaking at 405, 470, and 620 nm, respectively, arising from a rich intermolecular interaction network that generates novel emission centers, such as conformational isomers and excimers. This work inspires the rational molecular engineering of smart fluorophores with tailorable properties and inaugurates diverse possibilities for stimuli-responsive luminescent technologies

Additional file 2 of Identification of adenoid subtype characterized with immune-escaped phenotype in lung squamous carcinoma based on transcriptomics

Additional file 2: Figure S1. Demarcation of patients using a SNN modularity optimization-based clustering algorithm. A Unsupervised clustering of NSCLC samples with four clusters. B Unsupervised clustering of LUAD and LUSC samples. C Distribution of LUAD and LUSC samples in four different clusters. Figure S2. Associations between NSCLC subtypes and TME features. A Levels of stromal score, immune score, ESTIMATE score, and tumor purity in LUAD (n = 512), LUSC (n = 430), and LASC (n = 66) subtypes. Significance was calculated with One-way ANOVA with Tukey’s multiple comparisons test. ***P  0.05. Figure S7. FOLR1 is highly expressed in tumor cells in NSCLC. A Single-cell expression profile of FOLR1 in the GSE117570 dataset. B Single-cell expression profile of FOLR1 in the GSE131907 dataset

Additional file 1 of Identification of adenoid subtype characterized with immune-escaped phenotype in lung squamous carcinoma based on transcriptomics

Additional file 1. Additional methods

Additional file 1 of HLA class II molecule HLA-DRA identifies immuno-hot tumors and predicts the therapeutic response to anti-PD-1 immunotherapy in NSCLC

Additional file 1

Unlocking Multicolor Emissions in the Crystalline State through Dimerization and Configurational Transformation of a Single Fluorophore

Multicolor luminescent materials with tunable properties hold great promise for a wide range of applications in materials science. Unfortunately, the conventional approach to achieving multicolor emissions by blending multiple types of fluorophores is hindered by limitations, notably, spectral instability, aggregation-caused quenching, and energy transfer. The pursuit of multicolor emissions from a single type of fluorophore in the solid state has, until now, remained a formidable challenge. In this study, we have introduced N,N′-diphenyl dihydrodibenzo[a,c]-phenazines (DPAC), augmented with two o-carboranyl units, to create a novel fluorophore CbDPAC. The CbDPAC crystal exhibits three distinct emission bands peaking at 405, 470, and 620 nm, respectively, arising from a rich intermolecular interaction network that generates novel emission centers, such as conformational isomers and excimers. This work inspires the rational molecular engineering of smart fluorophores with tailorable properties and inaugurates diverse possibilities for stimuli-responsive luminescent technologies

Datasheet1_Recurrent lung adenocarcinoma benefits from microwave ablation following multidisciplinary treatments: A case with long-term survival.pdf

Lung cancer has become the leading cause of cancer death all over the world. Nowadays, there is a consensus that the treatment of non-small cell lung cancer (NSCLC) prefers a combination of multidisciplinary comprehensive treatment and individualized treatment, which can significantly improve the prognosis of patients. Here, we report a female patient with recurrence-prone NSCLC. She had a decade-long disease course, during which the lesion recurred twice and finally cured with Multi-Disciplinary Treatment (MDT). An elderly female patient was admitted to the hospital after diagnosis of lung cancer, and treated with surgery and postoperative adjuvant chemotherapy. Five years later, suspicious lesions were found by computed tomography (CT) reexamination, and then confirmed tumor recurrence by puncture biopsy. Based on the genetic test results, gefitinib was used for subsequent targeted therapy, and the lesion gradually shrunk to disappear. However, the lesion appeared again two years later, after consultation the microwave ablation was adopted and the curative effect was excellent. At last, regular reexamination showed no abnormality, the patient has survived so far. The case proves the great benefit of multidisciplinary comprehensive treatment, especially microwave ablation for patient with recurrence-prone NSCLC. And the effect of systemic anti-tumor immune response induced by microwave ablation on lung cancer also needs to be further explored.</p