17 research outputs found

    Supplemental Figures 1 - 10 from Melanoma Induces, and Adenosine Suppresses, CXCR3-Cognate Chemokine Production and T-cell Infiltration of Lungs Bearing Metastatic-like Disease

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    Supplemental Figure 1: Mice were given intravenous B16 injection on day 0. Supplemental Figure 2: Mice were given intravenous B16 injection on day 0.Supplemental Figure 3: Induced Braf/Pten tumors were harvested at 25 days or 40 days post-induction, corresponding to early (~5mm2) or late (~25mm2) tumors. Supplemental Figure 4: Chemokine production in melanoma. Supplemental Figure 5: Representative gating strategy for extracellular and intracellular staining. Supplemental Figure 6: Representative flow cytometry of Pmel CD8+ T cells stained for CD8 and CXCR3 after in vitro activation but before adoptive transfer. Supplemental Figure 7: Mice were given intravenous B16 injection on day 0. Supplemental Figure 8: Splenocytes were harvested from Pmel and Pmel-CXCR3-/- mice. Supplemental Figure 9: Naïve mice were injected (I.P.) with 50mg/kg aminophylline three times over the course of nine days. Supplemental Figure 10: Regulatory T cells in advanced melanomas express CD73.</p
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