Labyrinthine fístulae in chronic otitis media with cholesteatoma

The chronic otitis media with cholesteatoma (COMC) may evoluate to intracranial and extra cranial complications, including the labyrithine fístulae. In this study, we present the evolution of our patients with labyrinthine fístulae. STUDY DESIGN: Clinical prospective. MATERIAL AND METHOD: Ten out 82 patients with COMC had labyrinthine fístulae and underwent surgery from January/2001 to April/2002. They were assessed by clinical exam, computed tomography scans, and pre and postoperative audiogram. RESULTS: Hearing loss, otorrhea, tinnitus and dizziness were present in 100%, 90%,80%, and 40% of the cases. In one patient the fístulae was seen only in the coronal CT-scan, in another patient the fístulae was not seen neither in coronal nor axial images. Among the patients who had tinnitus, 66% referred improvement of this complaint after surgery. DISCUSSION: in the cases without invasion of the perilymphatic space, we noticed a tendency of improvement of the postoperative audiogram pattern and clinical outcome. In the extensive fístulae, on the other hand, there were no clinical changes. CONCLUSION: The CT-scan remains the best exam to assess the COMC with 90% of sensitivity for labyrinthine fístulae. In the stage II we had a good postoperative outcome.A otite média crônica colesteatomatosa (OMCC) pode cursar com complicações intra e/ou extracranianas, entre elas a fístula labiríntica. Neste trabalho, mostramos a incidência e a evolução dos casos de fístula labiríntica decorrentes da OMCC em nosso serviço. FORMA DE ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Dez pacientes com fístula labiríntica, do total de 82 pacientes com OMCC, foram submetidos à cirurgia no período de janeiro de 2001 a abril de 2002 e avaliados através de exame otorrinolaringológico completo, tomografia computadorizada e audiometria pré e pós-operatória. RESULTADOS: Perda auditiva, otorréia, zumbido e vertigem estavam presentes em 100%, 90%, 80% e 40% dos casos respectivamente na avaliação clínica pré-operatória. Em um paciente a fístula aparecia apenas nos cortes tomográficos coronais e tivemos um caso de falso-negativo. Dos pacientes com zumbido, 66% apresentaram melhora deste quadro no pós-operatório. DISCUSSÃO: Nos casos de fístula sem invasão do espaço perilinfático (até grau II), notamos uma tendência de melhora dos quadros clínico e audiométrico após a cirurgia. Nas fístulas extensas, por outro lado, o resultado audiométrico se manteve inalterado. CONCLUSÃO: A tomografia continua sendo o exame de escolha para os quadros de OMCC com sensibilidade de 90% para fístulas labirínticas. Nas fístulas grau II a cirurgia apresenta bom resultado funcional.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Otorrinolaringologia e Distúrbios da Comunicação HumanaUNIFESP, EPM, Depto. de Otorrinolaringologia e Distúrbios da Comunicação HumanaSciEL

Atherosclerosis in aged mice over-expressing the reverse cholesterol transport genes

We determined whether over-expression of one of the three genes involved in reverse cholesterol transport, apolipoprotein (apo) AI, lecithin-cholesterol acyl transferase (LCAT) and cholesteryl ester transfer protein (CETP), or of their combinations influenced the development of diet-induced atherosclerosis. Eight genotypic groups of mice were studied (AI, LCAT, CETP, LCAT/AI, CETP/AI, LCAT/CETP, LCAT/AI/CETP, and non-transgenic) after four months on an atherogenic diet. The extent of atherosclerosis was assessed by morphometric analysis of lipid-stained areas in the aortic roots. The relative influence (R²) of genotype, sex, total cholesterol, and its main sub-fraction levels on atherosclerotic lesion size was determined by multiple linear regression analysis. Whereas apo AI (R² = 0.22, P < 0.001) and CETP (R² = 0.13, P < 0.01) expression reduced lesion size, the LCAT (R² = 0.16, P < 0.005) and LCAT/AI (R² = 0.13, P < 0.003) genotypes had the opposite effect. Logistic regression analysis revealed that the risk of developing atherosclerotic lesions greater than the 50th percentile was 4.3-fold lower for the apo AI transgenic mice than for non-transgenic mice, and was 3.0-fold lower for male than for female mice. These results show that apo AI overexpression decreased the risk of developing large atherosclerotic lesions but was not sufficient to reduce the atherogenic effect of LCAT when both transgenes were co-expressed. On the other hand, CETP expression was sufficient to eliminate the deleterious effect of LCAT and LCAT/AI overexpression. Therefore, increasing each step of the reverse cholesterol transport per se does not necessarily imply protection against atherosclerosis while CETP expression can change specific athero genic scenarios.39139

mHealth in urology

Introduction: Smartphones are increasingly playing a role in healthcare and previous studies assessing medical applications (apps) have raised concerns about lack of expert involvement and low content accuracy. However, there are no such studies in Urology. We reviewed Urology apps with the aim of assessing the level of participation of healthcare professionals (HCP) and scientific Urology associations in their development. Material and Methods: A systematic search was performed on PubMed, Apple's App Store and Google's Play Store, for Urology apps, available in English. Apps were reviewed by three graders to determine the app's platform, target customer, developer, app type, app category, price and the participation of a HCP or a scientific Urology association in the development. Results: The search yielded 372 apps, of which 150 were specific for Urology. A fifth of all apps had no HCP involvement (20.7%) and only a third had been developed with a scientific Urology association (34.7%). The lowest percentage of HCP (13.4%) and urological association (1.9%) involvement was in apps designed for the general population. Furthermore, there was no contribution from an Urology society in "Electronic Medical Record" nor in "Patient Information" apps. A limitation of the study is that only Android and iOS apps were reviewed. Conclusions: Despite the increasing Mobile Health (mHealth) market, this is the first study that demonstrates the lack of expert participation in the design of Urology apps, particularly in apps designed for the general public. Until clear regulation is enforced, the urological community should help regulate app development. Maintaining a register of certified apps or issuing an official scientific seal of approval could improve overall app quality. We propose that urologists become stakeholders in mHealth, shaping future app design and promoting peer-review app validation

Fractional Wave-diffusion Equation With Periodic Conditions

We study a time-space fractional wave-diffusion equation with periodic conditions using Laplace transforms and Fourier series and presenting its solution in terms of three-parameter Mittag-Leffler functions. As a particular case we recover a recent result. We also present some graphics associated with particular values of the parameters. © 2012 American Institute of Physics.5312Caputo, M., Carcione, J.M., Hysteresis cycles and fatigue criteria using anelastic models based on fractional derivatives (2011) Rheol. Acta, 50 (2), pp. 107-115. , 10.1007/s00397-010-0524-zMainardi, F., Spada, G., Creep, relaxation and viscosity properties for basic fractional models in rheology (2011) Eur. Phys. J. Spec. Top., 193, pp. 133-160. , 10.1140/epjst/e2011-01387-1, e-print arXiv:cond-mat.mtrl.sci1110.3400v1Mainardi, F., Mura, A., Pagnini, G., The M-Wright function in time-fractional diffusion processes: A tutorial survey (2010) Int. J. Differ. Equations, 2010, p. 104505. , 10.1155/2010/104505, e-print arXiv:org/abs/1004.2950(2011) Fractional Dynamics, Recent Advances, , J. Klafter, S. C. Lim, R. Metzler, edited by and (World Scientific, Singapore, )Costa, F.S., Fractional thermal systems (2011) International Conference on Multimedia Technology (ICMT), , E. Capelas de Oliveira, Hangzhou, China, 26-28 JulyOliveira, E., Costa, F.S., Vaz, J., The fractional Schrödinger equation for delta potentials (2010) J. Math. Phys., 51, p. 123517. , 10.1063/1.3525976Oliveira, E., Vaz, J., Tunneling in fractional quantum mechanics (2011) J. Phys. A: Math. Theor., 44, p. 185303. , 10.1088/1751-8113/44/18/185303Machado, J.T., Kiryakova, V., Mainardi, F., Recent history of fractional calculus (2011) Nonlinear Sci. Number. Simul., 16, pp. 1140-1153. , 10.1016/j.cnsns.2010.05.027Podlubny, I., (1999) Fractional Differential Equations, , (Academic, San Diego, )Kilbas, A.A., Srivastava, H.M., Trujillo, J.J., (2006) Theory and Applications of Fractional Differential Equations, 204. , J. Van Mill, and Mathematics Studies, edited by (Elsevier, Amsterdam, )Zhang, H., Liu, F., The fundamental solutions of the space, space-time Riesz fractional partial differential equations with periodic conditions (2007) Numer. Math. J. Chin. Univ., 16, pp. 181-192Prabhakar, T.R., A singular integral equation with generalized Mittag-Leffler function in the kernel (1971) Yokohama Math. J., 19, pp. 7-25Samko, S.G., Kilbas, A.A., Marichev, O.I., (1993) Fractional Integrals and Derivatives: Theory and Applications, , (Gordon and Breach, New York, )Mainardi, F., Luchko, Y., Pagnini, G., The fundamental solution of the space-time fractional diffusion equation (2001) Fract. Calc. & Appl. Anal., 4 (2), pp. 153-192. , e-print arXiv:cond-mat.stat.mech/0702419v1Camargo, R., Charnet, R., de Oliveira, E., On the fractional Green function (2009) J. Math. Phys., 50, p. 043514. , 10.1063/1.311948

The Fractional Schrödinger Equation For Delta Potentials

The fractional Schrödinger equation is solved for the delta potential and the double delta potential for all energies. The solutions are given in terms of Fox's H-function. © 2010 American Institute of Physics.5112Rangarajan, G., Ding, M., (2000) Phys. Lett. A, 273, p. 322. , 10.1016/S0375-9601(00)00518-1Mainardi, F., (1996) Appl. Math. Lett., 9, p. 23. , 10.1016/0893-9659(96)00089-4Duan, J.S., (2005) J. Math. Phys., 46, p. 013504. , 10.1063/1.1819524Figueiredo Camargo, R., Capelas de Oliveira, E., Vaz, J., (2009) J. Math. Phys., 50, p. 123518. , 10.1063/1.3269587Laskin, N., (2000) Phys. Lett. A, 268, p. 298. , 10.1016/S0375-9601(00)00201-2Laskin, N., (2000) Phys. Rev. E, 62, p. 3135. , 10.1103/PhysRevE.62.3135(1995) Lévy Flights and Related Topics in Physics, 450. , M.F.Shlesinger, G.M.Zaslavsky, U.Frisch, edited by and, Lecture Notes in Physics, (Springer, New York)Guo, X., Xu, M., (2006) J. Math. Phys., 47, p. 082104. , 10.1063/1.2235026Laskin, N., (2000) Chaos, 10, p. 780. , 10.1063/1.1050284Naber, M., (2004) J. Math. Phys., 45, p. 3339. , 10.1063/1.1769611Jeng, M., Xu, S.-L.-Y., Hawkins, E., Schwarz, J.M., (2010) J. Math. Phys., 51, p. 062102. , 10.1063/1.3430552Dong, J., Xu, M., (2007) J. Math. Phys., 48, p. 072105. , 10.1063/1.2749172Butzer, P.L., Westphal, U., (2000) Applications of Fractional Calculus in Physics, pp. 1-85. , R.Hilfer, and, "An introduction to fractional calculus," in, edited by (World Scientific, Singapore)Riesz, M., (1948) Acta Math., 81, p. 1. , 10.1007/BF02395016Gradshteyn, I.S., Ryzhik, I.M., (2007) Table of Integrals, Series, and Products, , 7th ed. (Academic Press, NY)Gasiorowicz, S., (2003) Quantum Physics, , 3rd ed. (Wiley, NY)Scott, T.C., Babb, J.F., Dalmano, A., Morgan, J.D., (1993) J. Chem. Phys., 99, p. 2841. , 10.1063/1.465193Mathai, A.M., Saxena, R.K., Haubold, H.J., (2009) The H-Function, , (Springer, NY)Braaksma, B.L.J., (1962) Compos. Math., 15, p. 239. , 2013, 1964Kilbas, A.A., Srivastava, H.M., Trujillo, J.J., (2006) Theory and Applications of Fractional Differential Equations, , (Elsevier, Amsterdam)Oberhettinger, F., (1974) Tables of Mellin Transforms, , (Springer-Verlag, Berlin)Churchill, R.V., (1960) Complex Variables and Applications, , (McGraw-Hill, NY)Podlubny, I., (1998) Fractional Differential Equations, , (Academic Press, San Diego

Evaluation of the process of reabilitation of a stretch of Riparian forest in Itapemirim river watershed - ES

Este estudo foi realizado em uma área de floresta ciliar em processo de recuperação mediante reabilitação.A área de estudo está localizada na sub-bacia hidrográfica do rio Itapemirim, no Município de Alegre, ES, Brasil.A ocupação e uso do solo antes da revegetação eram de pastagem com Brachiaria sp. A revegetação da áreafoi feita em 1997, com espécies autóctones e alóctones arbóreas, em arranjo de distribuição aleatório, em umaárea de 1,2 ha. Para a realização dos estudos foram feitos inventários florestais nos períodos de 2004/2005e 2005/2006, sendo medidos os indivíduos de hábito arbustivo e arbóreo com circunferência à altura do peito(CAP) > 5 cm e suas alturas totais. As espécies encontradas na área foram identificadas e classificadas de acordocom seus grupos ecológicos, síndromes de dispersão e presença silvestre, sendo calculados os parâmetros florísticos,a estrutura vertical e a dinâmica estrutural desse povoamento. O objetivo do trabalho foi avaliar o desenvolvimentodo povoamento implantado para subsidiar práticas silviculturais quanto à seleção e implantação de espécies pararevegetação de áreas de floresta ciliar degradadas, em condições semelhantes. Os resultados demonstraram quefoi implantado um povoamento florestal com grande diversidade de espécies e a estratificação em classes dealtura foi à semelhança de povoamentos heterogêneos naturais. As espécies identificadas como edificadoras darevegetação da área estudada foram: Anadenanthera colubrina, Caesalpinia leyostachia, Acacia auriculiformis,Acacia mangium, Handroanthus serratifolius, Inga edulis, Joannesia princeps, Pterogyne nitens, Enterelobiumcontortisiliquum, Tabernaemontana hystrix e Anthocephalus indicus. A distribuição em classes de tamanho dacomunidade implantada ocorre em forma de "J" reverso, havendo a predominância de indivíduos pioneiros emtodas as classes de CAP. A dinâmica da estrutura horizontal apontou que, para o sucesso, continuidade e desenvolvimentoda recuperação da área, seja monitorada a regeneração natural em relação à sua presença e à eficiência dos fatoresbióticos e abióticos que nela interferem. A não observância de indivíduos arbustivos e arbóreos regenerados naturalmente,na classe de inclusão do estudo, indica a fragilidade inicial da área rumo à sustentabilidade do sistema.The study was realized in an area of riparian forest in process by means of rehabilitation. Thestudy area is located in Rio Itapemirim, in Alegre city, Brazil. The occupation and use of the soil beforethe recovery were of pasture with Brachiaria sp. The recovery of this area was in 1997, with autochthonousand allochthonous species, in casually distribution arrangement, in an area of 1,2 ha. For this studies wasrealized forest inventories in the periods of 2004/2005 and 2005/2006, being measured the arboreal individualswith circumference at breast height (CBH) and total heights. The species found in the area were identifiedand classified in this ecological groups, dispersion syndromes and wild presence, it forms calculated thefloristic parameters, the vertical structure and the structural dynamics of this plantation. The objective ofthis work went evaluate the development of the plantation implanted to subsidize practical silviculture withrelationship to the selection and plantation of species for the revegetation of degraded areas of riparianforest, in similar conditions. The results of the studies demonstrated that a forest plantation was implantedwith great diversity of species and the bedding in height classes it went to the likeness of natural heterogeneous.The species identified as builders of the plantation of the studied area were: Anadenanthera colubrina, Caesalpinia leyostachia, Acacia auriculiformis, Acacia mangium, Handroanthus serratifolius, Inga edulis, Joannesia princeps,Pterogyne nitens, Enterelobium contortisiliquum, Tabernaemontana hystrix, and Anthocephalus indicus . Theimplanted community's distribution diametric happens in reverse J shape having the pioneer individuals'predominance in all the classes of CBH. The dynamics of the horizontal structure points that for the success,continuity and development of the recovery of the area, the natural regeneration be monitored in relationto its presence and efficiency of the biotic factors and abiotic those interfere in the same. The not tree individualsobservance in natural regeneration, in the class of inclusion of the study, indicate the initial fragility of thearea heading for sustentabilidade of the system

Search for heavy resonances decaying into a vector boson and a Higgs boson in final states with charged leptons, neutrinos, and b quarks

Peer reviewe