The associations between the risk factors and cumulative indicator score of SEP (CIS) in the 1958 British birth cohort. Values are mean or prevalence.

<p>CI, confidence interval.</p><p>*Geometric means presented.</p>†<p>High alcohol consumption: alcohol consumption on most of the days</p>‡<p>Obese: BMI ≥ 30.</p

Association of overweight and obesity with wheeze and effect modification: OR with 95%-confidence intervals adjusted for sex.

+<p>Physical activity: 2 times a week or more often; ^*Fresh fruits are consumed 1 time per week or more often; ^§Med.Score: higher scores for more frequent consumption of vegetables (raw green and cooked), fruit, fruit juice and fish, and lower scores for more frequent consumption of meat, burger and fizzy drinks (for details see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113996#pone.0113996.s001" target="_blank">File S1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113996#pone.0113996.s002" target="_blank">S2</a>); ^&Low birthweight: less than 2500 g, normal: 2500–3499 g, high: more than 3500 g; ^$urban: suburban, with few parks or gardens or urban with no parks or gardens, rural: rural, open spaces or fields nearby or suburban, with many parks or gardens.</p><p>Association of overweight and obesity with wheeze and effect modification: OR with 95%-confidence intervals adjusted for sex.</p

The unadjusted and simultaneously adjusted regression analyses of D-dimer at 45years with social class at three stages of life in the 1958 British birth cohort.

<p>SC, social class; CI, confidence interval.</p><p>* Log transformed regression coefficients (β).</p>‡<p>Simultaneously adjusted with social class at three occasions.</p>†<p>Joint test of significance of social class at three stages of life</p

Atopic, familial and environmental associations with allergic conjunctivitis, rhinitis and rhinoconjunctivitis symptoms.

<p>*Odds ratios (OR) adjusted for age, sex, ever breast fed, month of examination, family history of allergy (except atopic history variables), number of older and younger siblings (except family size /order variables)</p><p>Atopic, familial and environmental associations with allergic conjunctivitis, rhinitis and rhinoconjunctivitis symptoms.</p

Seasonal variation in conjunctivitis symptoms by farming status.

<p>Seasonal variation in conjunctivitis symptoms by farming status.</p

Lowess plots i.e. smoothed curves of the average proportion of wheeze in the past year in relation to BMI (a: boys; b: girls).

<p>Lowess plots i.e. smoothed curves of the average proportion of wheeze in the past year in relation to BMI (a: boys; b: girls).</p

Geometric Means and standard deviation of D-dimer (ng/mL) concentration at 45 years by the social class at three occasions in the 1958 British Birth cohort.

<p>SC indicates social class; SC1, professional & managerial; SC2, non-manual; SC3, manual; SC4, unskilled.</p><p>SD, standard deviation.</p

Seasonal variation in Allergic Rhinitis/Conjunctivitis/Rhinoconjunctivitis current symptoms

<p>Seasonal variation in Allergic Rhinitis/Conjunctivitis/Rhinoconjunctivitis current symptoms</p

Odds ratios with 95%-confidence intervals (adjusted for sex) for the association of wheeze in the past year with overweight and obesity.

<p>Odds ratios with 95%-confidence intervals (adjusted for sex) for the association of wheeze in the past year with overweight and obesity.</p

Change in the regression coefficient of Cumulative Indicator Score of SEP (CIS) in association with D-dimer without- and with-adjustments with risk factors in the 1958 British Birth Cohort.

<p>Model 1: Association between D-dimer and Cumulative Indicator Score of SEP (CIS).</p><p>Model 2: Model 1 plus smoking, physical activity and alcohol consumption.</p><p>Model 3: Model 1 plus fibrinogen, C-reactive protein and vWF.</p><p>Model 4: Model 1 plus Framingham risk score and BMI.</p><p>Model 5: Model 1 plus all the factors mentioned above.</p><p>* Each unstandardised regression coefficient (<i>β</i>) represents the amount of change in the logarithmic concentration of D-dimer for an increase in CIS.</p>†<p>This is the change in the regression coefficient of CIS in the regression models compared to Model 1 e.g., ((<i>β</i>_{Model 1} − <i>β</i>_{Model 2})/<i>β</i>_{Model 1})*10.</p