Combination of a Fluorescent Dye and a Zn−S Cluster and Its Biological Application as a Stain for Bacteria

An ionic-pair charge-transfer salt [C15H16N3]+[Zn8S(SC6H5)15·H2O]− (1) featuring a fluorescent dye and a wurtzite-like octanuclear Zn−S cluster shows high stability when staining bacteria Escherichia coli, Salmonella typhimurium, and Clostridium novyi NT

Supplementary data: High-sensitivity workflow for LC-MS based analysis of GalNAc-conjugated oligonucleotides; a case study

Supplementary files including extraction details, hemolyzed plasma test results, recovery for ISTD and analyte, and matrix factors for analyte and internal standard

Combination of a Fluorescent Dye and a Zn−S Cluster and Its Biological Application as a Stain for Bacteria

An ionic-pair charge-transfer salt [C15H16N3]+[Zn8S(SC6H5)15·H2O]− (1) featuring a fluorescent dye and a wurtzite-like octanuclear Zn−S cluster shows high stability when staining bacteria Escherichia coli, Salmonella typhimurium, and Clostridium novyi NT

Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma - Fig 2

Receiver operator curve (ROC) analysis of the independent validation study using saliva-derived (A) miR-let-7a-5p and (B) miR-3928.</p

Demographic and clinical characteristics of HNSCC patients.

Demographic and clinical characteristics of HNSCC patients.</p

Expression of miR-let-7a-5p and miR-3928 in different groups of patients (n = 150) were classified by the habit of smoking and alcohol consumption.

Significance of two-sided p-values is indicated as follows: * p < 0.05 (t test).</p

Sequence, genomic location and primers of novel miRNAs.

Sequence, genomic location and primers of novel miRNAs.</p

Expression of candidate miRNA in supernatant saliva of subjects (n = 150) vs. control (n = 80).

(A) Significant decrease of miR-let-7a-5p, miR-3928. (B) Expression of miR-345-5p, miR-1470 and miR-7703, p-values is indicated as follows: * p < 0.05 and **** p < 0.001 (t test).</p

Expression of miR-let-7a-5p and miR-3928 in different groups of HNC patients (n = 150).

HNC patients were categorized according to clinical stage (T) and the presence [N+] and absence [N0] of lymph node metastasis. Significance of two-sided p-values indicated as follows: ** p < 0.01, **** P<0.0001 (t test).</p

Evaluating the complementary roles of an SJT and academic assessment for entry into clinical practice

Although there is extensive evidence confirming the predictive validity of situational judgement tests (SJTs) in medical education, there remains a shortage of evidence for their predictive validity for performance of postgraduate trainees in their first role in clinical practice. Moreover, to date few researchers have empirically examined the complementary roles of academic and non-academic selection methods in predicting in-role performance. This is an important area of enquiry as despite it being common practice to use both types of methods within a selection system, there is currently no evidence that this approach translates into increased predictive validity of the selection system as a whole, over that achieved by the use of a single selection method. In this preliminary study, the majority of the range of scores achieved by successful applicants to the UK Foundation Programme provided a unique opportunity to address both of these areas of enquiry. Sampling targeted high (>80th percentile) and low (<20th percentile) scorers on the SJT. Supervisors rated 391 trainees’ in-role performance, and incidence of remedial action was collected. SJT and academic performance scores correlated with supervisor ratings (r = .31 and .28, respectively). The relationship was stronger between the SJT and in-role performance for the low scoring group (r = .33, high scoring group r = .11), and between academic performance and in-role performance for the high scoring group (r = .29, low scoring group r = .11). Trainees with low SJT scores were almost five times more likely to receive remedial action. Results indicate that an SJT for entry into trainee physicians’ first role in clinical practice has good predictive validity of supervisor-rated performance and incidence of remedial action. In addition, an SJT and a measure of academic performance appeared to be complementary to each other. These initial findings suggest that SJTs may be more predictive at the lower end of a scoring distribution, and academic attainment more predictive at the higher end