Ab initio parametrised model of strain-dependent solubility of H in alpha-iron

The calculated effects of interstitial hydrogen on the elastic properties of alpha-iron from our earlier work are used to describe the H interactions with homogeneous strain fields using ab initio methods. In particular we calculate the H solublility in Fe subject to hydrostatic, uniaxial, and shear strain. For comparison, these interactions are parametrised successfully using a simple model with parameters entirely derived from ab initio methods. The results are used to predict the solubility of H in spatially-varying elastic strain fields, representative of realistic dislocations outside their core. We find a strong directional dependence of the H-dislocation interaction, leading to strong attraction of H by the axial strain components of edge dislocations and by screw dislocations oriented along the critical slip direction. We further find a H concentration enhancement around dislocation cores, consistent with experimental observations.Comment: part 2/2 from splitting of 1009.3784 (first part was 1102.0187), minor changes from previous version

Scaling Behaviour and Complexity of the Portevin-Le Chatelier Effect

The plastic deformation of dilute alloys is often accompanied by plastic instabilities due to dynamic strain aging and dislocation interaction. The repeated breakaway of dislocations from and their recapture by solute atoms leads to stress serrations and localized strain in the strain controlled tensile tests, known as the Portevin-Le Chatelier (PLC) effect. In this present work, we analyse the stress time series data of the observed PLC effect in the constant strain rate tensile tests on Al-2.5%Mg alloy for a wide range of strain rates at room temperature. The scaling behaviour of the PLC effect was studied using two complementary scaling analysis methods: the finite variance scaling method and the diffusion entropy analysis. From these analyses we could establish that in the entire span of strain rates, PLC effect showed Levy walk property. Moreover, the multiscale entropy analysis is carried out on the stress time series data observed during the PLC effect to quantify the complexity of the distinct spatiotemporal dynamical regimes. It is shown that for the static type C band, the entropy is very low for all the scales compared to the hopping type B and the propagating type A bands. The results are interpreted considering the time and length scales relevant to the effect.Comment: 35 pages, 6 figure

On piezophase effects in mechanically loaded atomic scale Josephson junctions

The response of an intrinsic Josephson contact to externally applied stress is considered within the framework of the dislocation-induced atomic scale Josephson effect. The predicted quasi-periodic (Fraunhofer-like)stress-strain and stress-current patterns should manifest themselves for experimentally accessible values of applied stresses in intrinsically defected (e.g.,twinned) crystals.Comment: REVTEX (epsf style), 2 EPS figure

Density hardening plasticity and mechanical aging of silica glass under pressure: A Raman spectroscopic study

In addition of a flow, plastic deformation of structural glasses (in particular amorphous silica) is characterized by a permanent densification. Raman spectroscopic estimators are shown to give a full account of the plastic behavior of silica under pressure. While the permanent densification of silica has been widely discussed in terms of amorphous-amorphous transition, from a plasticity point of view, the evolution of the residual densification with the maximum pressure of a pressure cycle can be discussed as a density hardening phenomenon. In the framework of such a mechanical aging effect, we propose that the glass structure could be labelled by the maximum pressure experienced by the glass and that the saturation of densification could be associated with the densest packing of tetrahedra only linked by their vertices

Non-Classical Response from Quench-Cooled Solid Helium Confined in Porous Gold

We have investigated the non-classical response of solid 4He confined in porous gold set to torsional oscillation. When solid helium is grown rapidly, nearly 7% of the solid helium appears to be decoupled from the oscillation below about 200 mK. Dissipation appears at temperatures where the decoupling shows maximum variation. In contrast, the decoupling is substantially reduced in slowly grown solid helium. The dynamic response of solid helium was also studied by imposing a sudden increase in the amplitude of oscillation. Extended relaxation in the resonant period shift, suggesting the emergence of the pinning of low energy excitations, was observed below the onset temperature of the non-classical response. The motion of a dislocation or a glassy solid is restricted in the entangled narrow pores and is not likely responsible for the period shift and long relaxation

FGFR2 amplification in colorectal adenocarcinoma

FGFR2 is recurrently amplified in 5% of gastric cancers and 1%–4% of breast cancers; however, this molecular alteration has never been reported in a primary colorectal cancer specimen. Preclinical studies indicate that several FGFR tyrosine-kinase inhibitors (TKIs), such as AZD4547, have in vitro activity against the FGFR2-amplified colorectal cell line, NCI-H716. The efficacy of these inhibitors is currently under investigation in clinical trials for breast and gastric cancer. Thus, better characterizing colorectal tumors for FGFR2 amplification could identify a subset of patients who may benefit from FGFR TKI therapies. Here, we describe a novel FGFR2 amplification identified by clinical next-generation sequencing in a primary colorectal cancer. Further characterization of the tumor by immunohistochemistry showed neuroendocrine differentiation, similar to the reported properties of the NCI-H716 cell line. These findings demonstrate that the spectrum of potentially clinically actionable mutations detected by targeted clinical sequencing panels is not limited to only single-nucleotide polymorphisms and insertions/deletions but also to copy-number alterations.</jats:p

Critical Dynamics of Burst Instabilities in the Portevin-Le Chatelier Effect

We investigate the Portevin-Le Chatelier effect (PLC), by compressing Al-Mg alloys in a very large deformation range, and interpret the results from the viewpoint of phase transitions and critical phenomena. The system undergoes two dynamical phase transitions between intermittent (or "jerky") and "laminar" plastic dynamic phases. Near these two dynamic critical points, the order parameter 1/\tau of the PLC effect exhibits large fluctuations, and "critical slowing down" (i.e., the number $\tau$ of bursts, or plastic instabilities, per unit time slows down considerably).Comment: the published 4-page version is in the PRL web sit

Particle displacements in the elastic deformation of amorphous materials: local fluctuations vs. non-affine field

We study the local disorder in the deformation of amorphous materials by decomposing the particle displacements into a continuous, inhomogeneous field and the corresponding fluctuations. We compare these fields to the commonly used non-affine displacements in an elastically deformed 2D Lennard-Jones glass. Unlike the non-affine field, the fluctuations are very localized, and exhibit a much smaller (and system size independent) correlation length, on the order of a particle diameter, supporting the applicability of the notion of local "defects" to such materials. We propose a scalar "noise" field to characterize the fluctuations, as an additional field for extended continuum models, e.g., to describe the localized irreversible events observed during plastic deformation.Comment: Minor corrections to match the published versio