Skeletal and Reduced Chemical Kinetic Mechanisms for Methyl Butanoate Autoignition

The methyl butanoate (MB) autoignition detailed mechanism including 275 species and 1545 elementary reactions was reduced through the systematic mechanism reduction approach. First, the smallest skeletal mechanism containing 79 species and 399 elementary reactions was achieved from the detailed mechanism by comparing four different graph-based reduction methods. Then, 123 unimportant reactions were eliminated using the computational singular perturbation (CSP), generating the ultimate skeletal mechanism consisting of 79 species and 276 elementary reactions. Finally, 26 global quasi-steady-state species were identified using a CSP-based time-scale analysis, resulting in a 53 species reduced mechanism. The 79 species skeletal and 53 species reduced mechanisms have been validated against the detailed mechanism, and the simulation results show good agreement with both the ignition delay time and the distribution of species concentration over a wide range of simulation conditions

Additional file 2 of The ferroptosis-related long non-coding RNAs signature predicts biochemical recurrence and immune cell infiltration in prostate cancer

Additional file 2: Supplemental Figure 2. Regulatory network and Sankey diagram of the 5 frlncRNAs. (A) The interactive network of frlncRNAs and mRNAs using Cytoscape. (B) Sankey diagram demonstrated the relationship between the 5 frlncRNAs, ferroptosis mRNAs and risk type

Additional file 1 of The ferroptosis-related long non-coding RNAs signature predicts biochemical recurrence and immune cell infiltration in prostate cancer

Additional file 1: Supplemental Figure 1. Heatmap showed the expression profiles of the 35 lncRNAs in PCa samples and normal controls

Additional file 7 of The ferroptosis-related long non-coding RNAs signature predicts biochemical recurrence and immune cell infiltration in prostate cancer

Additional file 7: Supplemental Table 2. A total of 669 frlncRNAs were identified by Pearson’s correlation analysis in 495 prostate patients with absolute correlation coefficient >0.30 and P < 0.001

Additional file 6 of The ferroptosis-related long non-coding RNAs signature predicts biochemical recurrence and immune cell infiltration in prostate cancer

Additional file 6: Supplemental Table 1. The PCR primers and siRNAs sequences in this study

Additional file 4 of The ferroptosis-related long non-coding RNAs signature predicts biochemical recurrence and immune cell infiltration in prostate cancer

Additional file 4: Supplemental Figure 4. The most significantly enriched pathways enriched in the low-risk group [20–22]. (A) propanoate metabolism. (B) valine leucine and isoleucine degradation. (C) butanoate metabolism. (D) adherens junction. (E) peroxisome. (F) citrate cycle tca cycle. (G) fatty acid metabolism. (H) n glycan biosynthesis. (I) sphingolipid metabolism. All FDR<0.25 and P<0.05

Image_1_v1_Application of “mosiac sign” on T2-WI in predicting the consistency of pituitary neuroendocrine tumors.tif

PurposeTumor consistency is important for pituitary neuroendocrine tumors (PitNETs) resection to improve surgical outcomes. In this study, we evaluated the T2-WI of PitNETs and defined a specific T2-WI signaling manifestation, the “Mosaic sign,” to predict tumor consistency and resection of PitNETs.DesignA retrospective review of MRI and tumor histology of 137 consecutive patients who underwent endoscopic endonasal resection for PitNETs was performed.MethodsThe “Mosaic sign” was defined by the ratio of the tumor itself T2-WI signals, and characterized by multiple intratumor hyperintense dots. The degree of tumor resection was an assessment by postoperative MRI examination. The presence of the “Mosaic sign” was compared with patients' basic information, tumor consistency, tumor pathological staining, and surgical result. To determine whether the presence or absence of “Mosaic sign” could predict tumor consistency and guide surgical resection of tumors.ResultsStatistical analysis showed that the consistency of the tumor and the degree of resection were correlated with the “Mosaic sign”. In the 137 cases of T2-WI, 43 had “Mosaic sign”, 39 cases had soft tumor consistency, and 4 were classified as fibrous, of which 42 were completely resected and 1 was subtotal resected. Of the 94 patients without “Mosaic sign”, the consistency of tumor of 54 cases were classified as soft, the remaining 40 cases were fibrous, 80 cases were completely resected, and 14 cases were subtotal resected. Postoperative cerebrospinal fluid leakage occurred in 1 patient. The number of corticotroph adenomas in the group of “Mosaic sign” was higher, with the statistical difference between the two groups (P = 0.0343).ConclusionsThe presence of the “Mosaic sign” in T2-WI may provide preoperative information for pituitary adenomas consistency and effectively guide surgical approaches.</p

Additional file 3 of The ferroptosis-related long non-coding RNAs signature predicts biochemical recurrence and immune cell infiltration in prostate cancer

Additional file 3: Supplemental Figure 3. The predictive ability of the model in all PCa patients. (A-B) The risk score and BCR states of every individual. (C-D) Effective clustering ability of risk score based on the 5 frlncRNAs in all patients. (E) Patients with high risk scores had shorter PSA-free survival expectancy. (F) ROCs showed the capability of risk score to predict BCR in all patients

Additional file 5 of The ferroptosis-related long non-coding RNAs signature predicts biochemical recurrence and immune cell infiltration in prostate cancer

Additional file 5: Supplemental Figure 5. Downstream of BCRP3. (A-B) Verification of knockdown efficiency. (C) Effects of BCRP3 on RB1, STAT3 and LAMP2 mRNA levels

Additional file 9 of The ferroptosis-related long non-coding RNAs signature predicts biochemical recurrence and immune cell infiltration in prostate cancer

Additional file 9: Supplemental Table 4. Baseline characteristics of enrolled cases