Additional file 1 of Light and dark sides of evidence-based and supportive ICU care for patients undergoing extracorporeal membrane oxygenation

Additional file 1: Figure S1. Patient flow chart. All 57 ICUs participated in the survey on the 3rd of June, 2020, were included in the 73 ICUs participated in the survey on the 1st of July, 2020. The 73 ICUs participated in the survey on the 1st of July, 2020, and the 135 ICUs participated in the survey on the 27th of January, 2021, could be overlapped but not be able to be identified because of the anonymous nature of the survey response

Results of univariable and multivariable Cox proportional hazard model of mortality in patients with H1N1 acute respiratory failure.

Results of univariable and multivariable Cox proportional hazard model of mortality in patients with H1N1 acute respiratory failure.</p

Treatment modalities and outcomes of patients with H1N1 acute respiratory failure.

Treatment modalities and outcomes of patients with H1N1 acute respiratory failure.</p

Cox proportional hazards model cumulative survival curve for patients with H1N1 acute respiratory failure each year (the solid line represents patients treated in 2016; the dotted line represents those treated in 2009).

Cox proportional hazards model cumulative survival curve for patients with H1N1 acute respiratory failure each year (the solid line represents patients treated in 2016; the dotted line represents those treated in 2009).</p

Characteristics, treatment modalities, and outcomes of patients with H1N1 acute respiratory failure who received ECMO treatment.

Characteristics, treatment modalities, and outcomes of patients with H1N1 acute respiratory failure who received ECMO treatment.</p

Baseline characteristics of patients with H1N1 acute respiratory failure.

Baseline characteristics of patients with H1N1 acute respiratory failure.</p

Study flow chart of patient inclusions and exclusions.

ICU, intensive care unit; NICU, neonatal intensive care unit.</p

Distribution of physical/occupational therapy according to age in Korean intensive care units.

ICU, intensive care unit. Overall p for trend < 0.01.</p

Data_Sheet_1_Overt disseminated intravascular coagulation and antithrombin III predict bleeding and in-hospital mortality in patients undergoing extracorporeal membrane oxygenation.docx

BackgroundLimited data are available on the relationship of disseminated intravascular coagulation (DIC) with mortality in patients receiving extracorporeal membrane oxygenation (ECMO). Thus, we investigated the association of DIC score and antithrombin (AT) III with clinical outcomes in patients undergoing ECMO.MethodsWe analyzed 703 patients who underwent ECMO between January 2014 and May 2022 at Samsung Medical Center. The DIC score was calculated using laboratory findings within 24 h of the ECMO initiation, and ≥ 5 was defined as overt DIC. In addition, the AT III level was measured to identify the correlation with the DIC score.ResultsAmong the study patients, 169 (24.0%) were diagnosed with overt DIC (DIC group) during early maintenance therapy. In-hospital mortality was significantly higher in the DIC group than in the non-DIC group (55.0% vs. 36.5%, p ConclusionOvert DIC was associated with higher in-hospital mortality and a tendency to bleed in ECMO patients. Furthermore, AT III plasma levels can easily predict overt DIC in patients undergoing ECMO. These findings suggest that monitoring AT III plasma levels may be important in the management of ECMO.</p

Claim codes for treatments or procedures.

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