Feasibility of using Y₂Ti₂O₇ nanoparticles to fabricate high strength oxide dispersion strengthened Fe-Cr-Al steels

Addition of Al can improve the corrosion resistance of oxide dispersion strengthened (ODS) steels. However, Al reacts with Y2O3 to form large Y-Al-O particles in the steels and deteriorates their mechanical properties. Herein, we successfully prepared Y2Ti2O7 nanoparticles (NPs) by the combination of hydrogen plasma-metal reaction (HPMR) and annealing. Y2Ti2O7 NPs with contents of 0.2 or 0.6 wt.% were then added into the Fe-14Cr-3Al-2W-0.35Ti (wt.%) steel to substitute the conventional Y2O3 NPs by mechanical alloying (MA). The Y2Ti2O7 NPs transformed into amorphous-like structure after 96 h MA. They crystallized with a fine size of 7.4±3.7 nm and shared a semi-coherent interface with the matrix after hot isostatic pressing (HIP) of the ODS steel with 0.6 wt.% Y2Ti2O7. With the increasing Y2Ti2O7 content from 0.2 to 0.6 wt.%, the tensile strength of the ODS steel increased from 1238 to 1296 MPa, which was much higher than that (949 MPa) of the ODS steel added with Y2O3. The remarkably improved mechanical properties of the Al-containing ODS steels were attributed to the increasing number density of Y2Ti2O7 nanoprecipitates. Our work demonstrates a novel route to fabricate high performance ODS steels with both high mechanical strength and good corrosion resistance

Coprocessing of Catalytic-Pyrolysis-Derived Bio-Oil with VGO in a Pilot-Scale FCC Riser

A catalytic-pyrolysis-derived bio-oil, which was characterized by higher H/C_eff ratio and lower oxygen content in comparison to fast-pyrolysis-derived bio-oil, was coprocessed with VGO in a pilot-scale FCC riser. The addition of the bio-oil up to 10 wt % gave nearly equivalent oxygenate content and also similar selectivities of gasoline, bottom oil, and coke compared to those in VGO catalytic cracking alone, suggesting the catalytic-pyrolysis-derived bio-oil was a suitable feedstock for FCC coprocessing. However, the dry gas, including hydrogen and light alkane, was significantly decreased in the coprocessing experiment mainly because of the hydrogen transfer between bio-oil and VGO. Radiocarbon analysis of the product showed that 7% carbon of gasoline was derived from the bio-oil when 10 wt % bio-oil was added to VGO. The coprocessing of biomass catalytic pyrolysis and FCC was highly promising for biomass conversion into biofuel

Ag-Assisted Fluorination of Unprotected 4,6-Disubstituted 2‑Aminopyrimidines with Selectfluor

A direct fluorination of 4,6-disubstituted 2-aminopyrimidines with Selectfluor in the presence of Ag­(I) is presented, affording the corresponding 4,6-disubstituted 5-fluoro-2-aminopyrimidines with acceptable to high yield. Ag­(I) is crucial for this chemoselective fluorination process. The transformation of 4,6-diphenyl 5-fluoro-2-aminopyrimidine into <i>N</i>-(5-fluoro-4,6-diphenylpyrimidin-2-yl)-4-methyl­benzene­sulfonamide is discussed, and the reaction mechanism is investigated, as well

Ag-Assisted Fluorination of Unprotected 4,6-Disubstituted 2‑Aminopyrimidines with Selectfluor

A direct fluorination of 4,6-disubstituted 2-aminopyrimidines with Selectfluor in the presence of Ag­(I) is presented, affording the corresponding 4,6-disubstituted 5-fluoro-2-aminopyrimidines with acceptable to high yield. Ag­(I) is crucial for this chemoselective fluorination process. The transformation of 4,6-diphenyl 5-fluoro-2-aminopyrimidine into <i>N</i>-(5-fluoro-4,6-diphenylpyrimidin-2-yl)-4-methyl­benzene­sulfonamide is discussed, and the reaction mechanism is investigated, as well

Ag-Assisted Fluorination of Unprotected 4,6-Disubstituted 2‑Aminopyrimidines with Selectfluor

A direct fluorination of 4,6-disubstituted 2-aminopyrimidines with Selectfluor in the presence of Ag­(I) is presented, affording the corresponding 4,6-disubstituted 5-fluoro-2-aminopyrimidines with acceptable to high yield. Ag­(I) is crucial for this chemoselective fluorination process. The transformation of 4,6-diphenyl 5-fluoro-2-aminopyrimidine into <i>N</i>-(5-fluoro-4,6-diphenylpyrimidin-2-yl)-4-methyl­benzene­sulfonamide is discussed, and the reaction mechanism is investigated, as well

Highly Efficient Separation of Magnesium and Lithium and High-Valued Utilization of Magnesium from Salt Lake Brine by a Reaction-Coupled Separation Technology

Lithium extraction from salt lake brines is one of the most important pathways for obtaining Li-related products, e.g., Li₂CO₃ and LiOH, and for further fabricating electric energy-storage products, e.g., lithium ion batteries. The high Mg/Li ratio and high Mg content are remarkable characteristics of the salt lakes in the Qaidam Basin in China, making the Mg/Li separation and Li extraction rather difficult. Herein, we proposed a reaction-coupled separation technology for Mg/Li separation from brine with a high Mg/Li ratio. The core idea of this technology is that the Mg²⁺ cations were reacted to form a solid via a nucleation–crystallization separation method. The solid product was MgAl-layered double hydroxide (MgAl-LDH), a widely used and high-valued product in the family of LDHs. The Li⁺ cations were left in the solution after Mg²⁺ cations were reacted with alkali solution, accompanied by foreign Al³⁺ cations. That is to say that the Mg²⁺ cations can be incorporated into the layers of MgAl-LDH while Li⁺ cations cannot. The findings indicated that Mg²⁺ cations were almost completely extracted into the solid phase to form the LDH. The Li⁺ cations remained in the solution having a weight loss less than 8%, which is an excellent level of Li extraction from the brine with a high Mg/Li ratio. The effects of reaction parameters, e.g., ionic strength, nucleation rotating speed, Mg/Al ratio, and crystallization temperature and time, on the separation performance and lithium loss were investigated. The optimal conditions were derived for lower lithium loss and more outstanding Mg/Li separation performance, which can be a useful guide for environmentally friendly and sustainable Li extraction from the brine

Table_2_The safety of sotagliflozin in the therapy of diabetes mellitus type 1 and type 2: A meta-analysis of randomized trials.docx

BackgroundDiabetes mellitus (DM) is a global health problem, and it has become a shocking threat in the contemporary era. The objective of this study was to analyze the safety of sotagliflozin in patients with DM systematically and intuitively.MethodsOn November 15, 2021, literature retrieval was performed on PubMed, Web of Science, EBSCO, and Cochrane libraries. The meta-analysis results included genital mycotic infection, related-to-acidosis events, and other related adverse events, including diarrhea, severe nocturnal hypoglycemia event, and volume depletion. In addition, a subgroup analysis was also conducted based on different doses of sotagliflozin. Moreover, the patient-treated years analyzed in the study were 12 weeks, 24 weeks, and 52 weeks, respectively, for type 1 diabetes, and were 12 weeks, 22 weeks, and 52 weeks, respectively, for type 2 diabetes.ResultsThe results of this meta-analysis illustrated that sotagliflozin could increase the risk of genital mycotic infection for patients with T1D and T2D (RR: 3.49, 95% Cl: 2.54-4.79, p ConclusionsThis meta-analysis showed that the adverse events of sotagliflozin were tolerable to patients with DM, in terms of the incidence of genital mycotic infection, related-to-acidosis events, diarrhea, volume depletion, and severe nocturnal hypoglycemia events. In addition, the subgroup analysis of sotagliflozin dosage is considered to have great clinical significance for future guidance of sotagliflozin application in patients with DM.</p

Image_1_The safety of sotagliflozin in the therapy of diabetes mellitus type 1 and type 2: A meta-analysis of randomized trials.tif

BackgroundDiabetes mellitus (DM) is a global health problem, and it has become a shocking threat in the contemporary era. The objective of this study was to analyze the safety of sotagliflozin in patients with DM systematically and intuitively.MethodsOn November 15, 2021, literature retrieval was performed on PubMed, Web of Science, EBSCO, and Cochrane libraries. The meta-analysis results included genital mycotic infection, related-to-acidosis events, and other related adverse events, including diarrhea, severe nocturnal hypoglycemia event, and volume depletion. In addition, a subgroup analysis was also conducted based on different doses of sotagliflozin. Moreover, the patient-treated years analyzed in the study were 12 weeks, 24 weeks, and 52 weeks, respectively, for type 1 diabetes, and were 12 weeks, 22 weeks, and 52 weeks, respectively, for type 2 diabetes.ResultsThe results of this meta-analysis illustrated that sotagliflozin could increase the risk of genital mycotic infection for patients with T1D and T2D (RR: 3.49, 95% Cl: 2.54-4.79, p ConclusionsThis meta-analysis showed that the adverse events of sotagliflozin were tolerable to patients with DM, in terms of the incidence of genital mycotic infection, related-to-acidosis events, diarrhea, volume depletion, and severe nocturnal hypoglycemia events. In addition, the subgroup analysis of sotagliflozin dosage is considered to have great clinical significance for future guidance of sotagliflozin application in patients with DM.</p

Supplementary document for Optical spectrum detection of synthetic microsphere resonator using a nanofiber - 5980481.pdf

Supplemental document</p

Influenza viruses used in this study.

<p>Influenza viruses used in this study.</p