Overall survival curves of lncRNAs in LGG.

(A-V) 22 lncRNAs were significantly associated with OS of LGG. (TIF)</p

Progress free interval curves of CDCA2 in cancers.

(A) ACC; (B) BLCA; (C) ESCC; (D) KIRC; (E) KIRP; (F) LGG; (G) LIHC; (H) LUAD; (I) MESO; (J) PAAD; (K) SARC. (TIF)</p

miRNAs binding to CDCA2 in LGG.

(A) 6 miRNAs that might bind to CDCA2; (B-G) Survival analyses of 6 miRNAs in LGG; (H-K) Correlation between CDCA2 and miRNAs.</p

Nomogram model and calibration curves.

(A) Nomogram model predicting the 1-, 3- and 5-year OS in patients with LGG. The calibration curves for nomogram at (B) 1 year, (C) 3 years and (D) 5 years.</p

Enrichment analysis of CDCA2 in LGG.

(A, B) Top 100 positive and negative co-expressed genes with CDCA2 in LGG. (C, D) GO and KEGG analyses of CDCA2 related genes. (E) GSEA for differentially expressed genes of CDCA2.</p

lncRNAs binding to miRNA-105-5p in LGG.

(A, B) 52 lncRNAs predicted to interact with miRNA-105-5p; (C-F) Correlation between lncRNAs and miRNA-105-5p; (G) a lncRNA-miRNA-mRNA ceRNA network.</p

Associations between CDCA2 expression and m6A-related genes in LGG.

(A-T) The correlation between CDCA2 and m6A related genes; (U) The differential expression of m6A related genes in the high and low CDCA2 expression groups in LGG (*p < 0.05, **p < 0.01, ***p < 0.001).</p

Correlations between CDCA2 expression and immune subtypes across TCGA tumors.

(A) ACC; (B) BLCA; (C) BRCA; (D) COAD; (E) ESCA; (F) KIRC; (G) KIRP; (H) LGG; (I) LIHC; (J) LUAD; (K) LUSC; (L) MESO; (M) OV; (N) PAAD; (O) PRAD; (P) READ; (Q) SARC; (R) SKCM; (S) STAD; (T) TGCT; (U) THCA; (V) UCEC.</p

Associations between CDCA2 expression and immune cell infiltration in LGG.

(A) The correlation between CDCA2 and immune cell infiltration; (B, C, D) The correlation between CDCA2 and stromalscore, immune score and estimate score; (E) The differential expression of immune cells in the high and low CDCA2 expression groups in LGG; The relationship between the different infiltration levels of immune cells and the prognosis of patients with LGG (Fig 12F–12I) (*p < 0.05, **p < 0.01, ***p < 0.001).</p

Univariate and multivariate Cox regression analyses of clinical features of LGG associated with OS.

Univariate and multivariate Cox regression analyses of clinical features of LGG associated with OS.</p