Regional shape alteration of left thalamus associated with late chronotype in young adults

Chronotype reflects individual differences in circadian rhythms and influences individual psychology and behavior. Previous studies found altered subcortical structures are closely related to individual chronotypes. However, these studies have been conducted mainly using voxel-based morphometry and traditional volume measurement methods with certain limitations. This study aimed to investigate subcortical aberrant volume and shape patterns in late chronotypes (LC) young adults compared to early chronotypes (EC) young adults. Magnetic resonance imaging (MRI) scanning and chronotype assessment were performed once for all participants, including 49 LC young adults and 49 matched EC young adults. The morningness and eveningness preferences were assessed using the Chronotype Questionnaire. A vertex-wise shape analysis was conducted to analyze structural MRI data. There were no significant differences in brain tissue volume and subcortical structural volume between groups. LC young adults showed significant regional shape atrophy in the left ventral posterior thalamus compared to EC individuals. A significant correlation was found between the regional shape atrophy of left ventral posterior thalamus and the score of Chronotype Questionnaire in LC young adults. Regional shape alteration of left thalamus was closely related to the chronotype, and LC may be a potential risk factor for sleep-related behavioral and mental problems in young adults. However, the predominantly female sample and the failure to investigate the effect of chronotype on the subcortical structure-function network are limitations of this study. Further prospective studies are needed to investigate the temporal characteristics of thalamic shape changes and consequent behavioral and psychiatric problems in adults with LC.</p

sj-pdf-1-imr-10.1177_03000605231198742 - Supplemental material for Plasma exchange for anti-MDA5 antibody-positive dermatomyositis-associated rapidly progressive interstitial lung disease: A case report and literature review

Supplemental material, sj-pdf-1-imr-10.1177_03000605231198742 for Plasma exchange for anti-MDA5 antibody-positive dermatomyositis-associated rapidly progressive interstitial lung disease: A case report and literature review by Ci Lu, Cheng Xu, Xiaoying Zhu and Yongmei Han in Journal of International Medical Research</p

Who will follow the leader? Managers' perceptions of management development activities: an international comparison: SKOPE Research Paper No. 51, Autumn 2004

This article contributes to the on-going debate surrounding management education and development through an examination of the development experiences of managers studying for an MBA by distance learning at Warwick Business School. It analyses the extent to which management development opportunities, both formal and informal, are seen to support managers in their day-to-day roles and deliver those skills necessary for the future. The research also provides the opportunity to compare responses from UK managers with those from managers in other countries. The survey evidence shows that in some respects the experience of UK and Overseas respondents are quite similar; they both receive large amounts of training and development from their employers and show a preference for more ‘non-formal’ routes of learning. In other ways their experiences are quite different: UK managers take up their first full-time job and their first managerial appointment earlier than the overseas respondents and overseas respondents placed much more emphasis on networking and learning from outside their own organisations than did UK managers. The research also suggests that integrating management development activities with other human resource policies and practices, such as performance evaluation and reward remains problematic and that there is a strong perception amongst managers both in the UK and overseas that their organisations do not view management development in a strategic way. When looking at future development needs respondents from both the UK and overseas highlighted the need for leadership skills as a priority for themselves but focused on more general management and operational skills as the main priority for their colleagues. One possible explanation for this is that the respondents were only to well aware of the fact that that leaders need followers. This is, however, a view at which is at odds with current policy arguments in the UK where leadership skills are seen to be necessary for all managers

Rare earth element enrichment in Palaeoproterozoic Fengzhen carbonatite from the North China block

<p>Carbonatites are characterized by the highest concentration of rare earth elements (REEs) of any igneous rock and are therefore good targets for REE exploration. Supergene, hydrothermal, and magmatic REE deposits associated with carbonatites have been widely studied. REE enrichment related to fluorapatite metasomatism in Fengzhen carbonatites in the North China block is reported in this study. REE minerals (monazite, britholite, and Ca-REE-fluorocarbonates) associated with barite and quartz formed as inclusions within the fluorapatite and externally on its surface. Monazite, allanite, barite, and quartz occur as rim grains on the edges of the fluorapatite. Zoned fluorapatite was observed and showed varying chemical composition. Based on back-scattered electron imaging, the dark domains with mineral inclusions contain lower Si (0.3–0.6 wt.% SiO₂) and light REE (LREE) [0.36–1.54 wt.% (Y+LREE)₂O₃] contents than inclusion-poor areas [0.7–1 wt.% SiO₂; 2.16–4.51 wt.% (Y + LREE)₂O₃]. This indicates a dissolution–re-precipitation texture. Different types of monazites were distinguished by their chemical compositions. Monazite inclusions have lower La₂O₃contents (~13 wt.%) and La/Nd_cn (~3) ratios than those (18–26 wt.% and 10–14 for La₂O₃ and La/Nd_cn, respectively) growing externally on the fluorapatite. REE enrichment in the metasomatic fluorapatites is related to different stages of carbonatitic liquids. The early carbonatite-exsolved fluids metasomatized the fluorapatites to form REE mineral inclusions. The late carbonatitic fluids from carbonatite magmas that underwent strong fractional crystallization were enriched in REEs, Al, and Fe and metasomatized the fluorapatites to produce allanite and monazite rim grains.</p

Image_3_The optimal regional irradiation volume for breast cancer patients: A comprehensive systematic review and network meta-analysis of published studies.jpeg

BackgroundCurrently, the optimal adjuvant regional nodal irradiation (RNI) volume for breast cancer (BC) remained controversial. We aimed to define the optimal RNI treatment volume for BC by using a comprehensive network meta-analysis (NMA) of published studies.Materials and methodsPubMed, Embase, Medline, and Cochrane Central Register of Controlled Trials were searched from database inception to 30 May 2022. Studies assessing different adjuvant RNI volumes for BC were eligible for inclusion. The primary outcome was overall survival (OS), and secondary outcome was disease-free survival (DFS) and distant-metastasis-free survival (DMFS).ResultsA total of 29,640 BC patients from twenty studies were included. The pooled hazard ratio demonstrated that internal mammary node irradiation (IMNI) in BC patients significantly improved OS giving HR (hazard ratio) of 0.87 (95%CI: 0.83–0.91, pConclusionsOur pooled results demonstrated that RNI with IMNI yielded a significant survival advantage for BC patients. NMA showed that CW/WB+RNI with IMNI was the optimal radiation volume for BC patients.</p

Table_2_The optimal regional irradiation volume for breast cancer patients: A comprehensive systematic review and network meta-analysis of published studies.docx

BackgroundCurrently, the optimal adjuvant regional nodal irradiation (RNI) volume for breast cancer (BC) remained controversial. We aimed to define the optimal RNI treatment volume for BC by using a comprehensive network meta-analysis (NMA) of published studies.Materials and methodsPubMed, Embase, Medline, and Cochrane Central Register of Controlled Trials were searched from database inception to 30 May 2022. Studies assessing different adjuvant RNI volumes for BC were eligible for inclusion. The primary outcome was overall survival (OS), and secondary outcome was disease-free survival (DFS) and distant-metastasis-free survival (DMFS).ResultsA total of 29,640 BC patients from twenty studies were included. The pooled hazard ratio demonstrated that internal mammary node irradiation (IMNI) in BC patients significantly improved OS giving HR (hazard ratio) of 0.87 (95%CI: 0.83–0.91, pConclusionsOur pooled results demonstrated that RNI with IMNI yielded a significant survival advantage for BC patients. NMA showed that CW/WB+RNI with IMNI was the optimal radiation volume for BC patients.</p

Table_3_The optimal regional irradiation volume for breast cancer patients: A comprehensive systematic review and network meta-analysis of published studies.docx

BackgroundCurrently, the optimal adjuvant regional nodal irradiation (RNI) volume for breast cancer (BC) remained controversial. We aimed to define the optimal RNI treatment volume for BC by using a comprehensive network meta-analysis (NMA) of published studies.Materials and methodsPubMed, Embase, Medline, and Cochrane Central Register of Controlled Trials were searched from database inception to 30 May 2022. Studies assessing different adjuvant RNI volumes for BC were eligible for inclusion. The primary outcome was overall survival (OS), and secondary outcome was disease-free survival (DFS) and distant-metastasis-free survival (DMFS).ResultsA total of 29,640 BC patients from twenty studies were included. The pooled hazard ratio demonstrated that internal mammary node irradiation (IMNI) in BC patients significantly improved OS giving HR (hazard ratio) of 0.87 (95%CI: 0.83–0.91, pConclusionsOur pooled results demonstrated that RNI with IMNI yielded a significant survival advantage for BC patients. NMA showed that CW/WB+RNI with IMNI was the optimal radiation volume for BC patients.</p

Table_6_The optimal regional irradiation volume for breast cancer patients: A comprehensive systematic review and network meta-analysis of published studies.docx

BackgroundCurrently, the optimal adjuvant regional nodal irradiation (RNI) volume for breast cancer (BC) remained controversial. We aimed to define the optimal RNI treatment volume for BC by using a comprehensive network meta-analysis (NMA) of published studies.Materials and methodsPubMed, Embase, Medline, and Cochrane Central Register of Controlled Trials were searched from database inception to 30 May 2022. Studies assessing different adjuvant RNI volumes for BC were eligible for inclusion. The primary outcome was overall survival (OS), and secondary outcome was disease-free survival (DFS) and distant-metastasis-free survival (DMFS).ResultsA total of 29,640 BC patients from twenty studies were included. The pooled hazard ratio demonstrated that internal mammary node irradiation (IMNI) in BC patients significantly improved OS giving HR (hazard ratio) of 0.87 (95%CI: 0.83–0.91, pConclusionsOur pooled results demonstrated that RNI with IMNI yielded a significant survival advantage for BC patients. NMA showed that CW/WB+RNI with IMNI was the optimal radiation volume for BC patients.</p

Table_4_The optimal regional irradiation volume for breast cancer patients: A comprehensive systematic review and network meta-analysis of published studies.docx

BackgroundCurrently, the optimal adjuvant regional nodal irradiation (RNI) volume for breast cancer (BC) remained controversial. We aimed to define the optimal RNI treatment volume for BC by using a comprehensive network meta-analysis (NMA) of published studies.Materials and methodsPubMed, Embase, Medline, and Cochrane Central Register of Controlled Trials were searched from database inception to 30 May 2022. Studies assessing different adjuvant RNI volumes for BC were eligible for inclusion. The primary outcome was overall survival (OS), and secondary outcome was disease-free survival (DFS) and distant-metastasis-free survival (DMFS).ResultsA total of 29,640 BC patients from twenty studies were included. The pooled hazard ratio demonstrated that internal mammary node irradiation (IMNI) in BC patients significantly improved OS giving HR (hazard ratio) of 0.87 (95%CI: 0.83–0.91, pConclusionsOur pooled results demonstrated that RNI with IMNI yielded a significant survival advantage for BC patients. NMA showed that CW/WB+RNI with IMNI was the optimal radiation volume for BC patients.</p

Table_1_The optimal regional irradiation volume for breast cancer patients: A comprehensive systematic review and network meta-analysis of published studies.docx

BackgroundCurrently, the optimal adjuvant regional nodal irradiation (RNI) volume for breast cancer (BC) remained controversial. We aimed to define the optimal RNI treatment volume for BC by using a comprehensive network meta-analysis (NMA) of published studies.Materials and methodsPubMed, Embase, Medline, and Cochrane Central Register of Controlled Trials were searched from database inception to 30 May 2022. Studies assessing different adjuvant RNI volumes for BC were eligible for inclusion. The primary outcome was overall survival (OS), and secondary outcome was disease-free survival (DFS) and distant-metastasis-free survival (DMFS).ResultsA total of 29,640 BC patients from twenty studies were included. The pooled hazard ratio demonstrated that internal mammary node irradiation (IMNI) in BC patients significantly improved OS giving HR (hazard ratio) of 0.87 (95%CI: 0.83–0.91, pConclusionsOur pooled results demonstrated that RNI with IMNI yielded a significant survival advantage for BC patients. NMA showed that CW/WB+RNI with IMNI was the optimal radiation volume for BC patients.</p