Additional file 2 of Safety and efficacy of vacuum bottle plus catheter for drainage of iatrogenic pneumothorax

Additional file 2: Text S1. Procedure protocol with illustrating figures. Fig. S1. Pressure-time curve of end-expiratory intrapleural pressure measurement during air drainage by vacuum bottle plus non-tunneled catheter in 21 patients. Fig. S2. Box plots in combination with scattered dot plots for participants' discomfort in the numeric rating scale of 10 recording before, during and after the procedure.  Fig. S3. Scatter plots of time to event-free duration to pneumothorax size in control group. Table S1. Comparison of studies employing simple air aspiration in patients with iatrogenic or traumatic pneumothoraces

Additional file 1 of Patient experience with bronchoscopy: topical versus monitored anesthesia

Supplementary Material

Prospective Evaluation of Procalcitonin, Soluble Triggering Receptor Expressed on Myeloid Cells-1 and C-Reactive Protein in Febrile Patients with Autoimmune Diseases

<div><p>Background</p><p>Both procalcitonin (PCT) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) have been investigated separately as indicators of infection in patients with autoimmune diseases. Our study simultaneously evaluated both PCT and sTREM-1 along with C-reactive protein (CRP) in febrile patients with autoimmune diseases.</p><p>Methods</p><p>Fifty-nine patients were enrolled in the study. The patients were categorized into the infection group (n = 24) or the disease flare group (n = 35). sTREM-1, PCT and CRP concentrations at fever onset were compared between the two groups of patients.</p><p>Results</p><p>sTREM-1 and CRP did not differ between the two groups. PCT [median (range), ng/ml] was higher in the infection group than in the disease flare group [0.53 (0.02–12.85) vs. 0.12 (0.02–19.23), <i>p</i> = 0.001]. The area under the receiver-operating characteristic (ROC) for diagnosis of infection was 0.75 for PCT (<i>p</i> = 0.001), 0.63 for CRP (<i>p</i> = 0.09) and 0.52 for sTREM-1 (<i>p =</i> 0.79). Using 0.2 ng/ml as the cutoff value for PCT, sensitivity was 0.75 and specificity was 0.77. Negative predictive values for PCT were 92%, 87% and 82% for a prevalence of infection of 20%, 30%, and 40%, respectively. Neither immunosuppressants nor biomodulators affected the level of the three biomarkers. However, in patients treated with corticosteroids, the levels of sTREM-1 and CRP were significantly decreased compared with the untreated patients.</p><p>Conclusions</p><p>Setting PCT at a lower cutoff value could provide useful information on excluding infection in febrile patients with autoimmune diseases. The possible effect of corticosteroids on the level of sTREM-1 as an infection marker deserves further study.</p></div

The receiver-operating characteristic (ROC) curves of soluble triggering receptor expressed on myeloid cells-1(sTREM-1), procalcitonin (PCT), and C-reactive protein (CRP) for prediction of infection.

<p>The area under the ROC curve was 0.52 for sTREM-1, 0.76 for PCT and 0.63 for CRP.</p

Multivariate analysis to determine independent risk factors for pneumothorax.

<p>Multivariate analysis to determine independent risk factors for pneumothorax.</p

Univariate analysis to determine risk factors for pneumothorax^*.

*<p>Data are presented as mean±SD or No. (%).</p>#<p>Cavity, mixed ground-glass opacity, and pure ground-glass opacity.</p

Effects of immunosuppressants, biomodulators and corticosteroids on the level of the three biomarkers.

<p>Effects of immunosuppressants, biomodulators and corticosteroids on the level of the three biomarkers.</p

Infectious diagnosis of the 24 patients.

<p>Infectious diagnosis of the 24 patients.</p

Individual plasma levels and medians of (A) soluble triggering receptor expressed on myeloid cells-1(sTREM-1); (B) procalcitonin (PCT); and (C) C-reactive protein (CRP) in the two groups.

The horizontal bars represent the median values.</p

Clinical characteristics of the two groups of febrile patients with autoimmune diseases.

<p>Clinical characteristics of the two groups of febrile patients with autoimmune diseases.</p