Additional file 2: of Influence of maternal and own genotype at tanning dependence-related SNPs on sun exposure in childhood

Supplementary data for the influence of maternal and own genotype at tanning dependence-related SNPs on sun exposure in childhood. This file contains Tables S1–S6 which includes a list of SNPs and relevant details) selected for analysis, a correlation matrix of sun exposure variables, a complete table of the associations between tanning dependence related SNPS and sun exposure, and the number of SNPs associated with each measured sun exposure variable prior to Bonferroni correction. Additionally, the file contains a table of associations between SNPs and pigmentation variables, and a table of associations between tanning dependence related SNPS and sun exposure stratified by sex. (XLSX 331 kb

Additional file 1: of Influence of maternal and own genotype at tanning dependence-related SNPs on sun exposure in childhood

Questionnaire of sun exposure completed by mothers about their children at 8 years old. This file contains the questionnaire used to assess children’s sun exposure at 8 years. The questionnaire was completed by the mothers about their children. (DOCX 188 kb

Mitochondrial DNA Haplogroups and Breast Cancer Risk Factors in the Avon Longitudinal Study of Parents and Children (ALSPAC)

The relationship between mitochondrial DNA (mtDNA) and breast cancer has been frequently examined, particularly in European populations. However, studies reporting associations between mtDNA haplogroups and breast cancer risk have had a few shortcomings including small sample sizes, failure to account for population stratification and performing inadequate statistical tests. In this study we investigated the association of mtDNA haplogroups of European origin with several breast cancer risk factors in mothers and children of the Avon Longitudinal Study of Parents and Children (ALSPAC), a birth cohort that enrolled over 14,000 pregnant women in the Southwest region of the UK. Risk factor data were obtained from questionnaires, clinic visits and blood measurements. Information on over 40 independent breast cancer risk factor-related variables was available for up to 7781 mothers and children with mtDNA haplogroup data in ALSPAC. Linear and logistic regression models adjusted for age, sex and population stratification principal components were evaluated. After correction for multiple testing we found no evidence of association of European mtDNA haplogroups with any of the breast cancer risk factors analysed. Mitochondrial DNA haplogroups are unlikely to underlie susceptibility to breast cancer that occurs via the risk factors examined in this study of a population of European ancestry

Mitochondrial DNA Haplogroups and Breast Cancer Risk Factors in the Avon Longitudinal Study of Parents and Children (ALSPAC)

The relationship between mitochondrial DNA (mtDNA) and breast cancer has been frequently examined, particularly in European populations. However, studies reporting associations between mtDNA haplogroups and breast cancer risk have had a few shortcomings including small sample sizes, failure to account for population stratification and performing inadequate statistical tests. In this study we investigated the association of mtDNA haplogroups of European origin with several breast cancer risk factors in mothers and children of the Avon Longitudinal Study of Parents and Children (ALSPAC), a birth cohort that enrolled over 14,000 pregnant women in the Southwest region of the UK. Risk factor data were obtained from questionnaires, clinic visits and blood measurements. Information on over 40 independent breast cancer risk factor-related variables was available for up to 7781 mothers and children with mtDNA haplogroup data in ALSPAC. Linear and logistic regression models adjusted for age, sex and population stratification principal components were evaluated. After correction for multiple testing we found no evidence of association of European mtDNA haplogroups with any of the breast cancer risk factors analysed. Mitochondrial DNA haplogroups are unlikely to underlie susceptibility to breast cancer that occurs via the risk factors examined in this study of a population of European ancestry

Medical geneticists, genetic diseases and services in Brazil in the age of personalized medicine Supplementary Figures rev2

Medical geneticists, genetic diseases and services in Brazil in the age of personalized medicine Supplementary Figures rev2</p

Medical geneticists, genetic diseases and services in Brazil in the age of personalized medicine Supplementary Tables rev2

Medical geneticists, genetic diseases and services in Brazil in the age of personalized medicine Supplementary Tables rev2</p

Supplementary Table 3 from Using Genetic Proxies for Lifecourse Sun Exposure to Assess the Causal Relationship of Sun Exposure with Circulating Vitamin D and Prostate Cancer Risk

PDF file - 37K, Association between genetic scores in tertiles and prostate cancer status, adjusted for age at recruitment and population stratification.</p

Supplementary Table 2 from Using Genetic Proxies for Lifecourse Sun Exposure to Assess the Causal Relationship of Sun Exposure with Circulating Vitamin D and Prostate Cancer Risk

PDF file - 37K, Distribution of pigmentation genetic scores across the nine centers contributing participants to ProtecT.</p

Supplementary Table 1 from Using Genetic Proxies for Lifecourse Sun Exposure to Assess the Causal Relationship of Sun Exposure with Circulating Vitamin D and Prostate Cancer Risk

PDF file - 40K, Association between pigmentation genetic scores and the first 10 principal components that reflect population stratification.</p

Association of maternal <i>TCN2</i> haplotypes with vitamin B-12 cord blood levels and offspring IQ at age 8.

a<p>p-value for testing the effect of each haplotype vs all others.</p>b<p>p-value for the omnibus test that compares the alternate model (each haplotype having a unique effect) vs the null model (no haplotypes having any effect).</p>c<p>N corresponds to the number of mothers with available genotype data for both SNPs (N = 5866), whose children had vitamin B-12 measured in cord blood (N = 202), or whose children had been IQ tested (N = 3429).</p