Additional file 1 of Insulin-like growth factor 5 associates with human Aß plaques and promotes cognitive impairment

Additional file 1. Online Resource Supplementary Material and Figures

Additional file 3 of Differences in stem cell marker and osteopontin expression in primary and recurrent glioblastoma

Additional file 3: Figure S2. Overall survival shown by Kaplan-Meier curves for Musashi (A), Nanog (B), Oct4 (C) and Osteopontin (D) expressed in primary and recurrent tumor. Curves are divided by the median expression rate of the corresponding marker. None of the markers was significantly associated with overall survival

Comparison of ⁶⁸Ga-DOTATATE uptake and MR contrast agent enhancement.

<p>In all 3 patients, there is a marked overlap between ⁶⁸Ga-DOTATATE uptake and MR contrast agent enhancement. Radiotracer accumulation is most pronounced in areas with intense contrast enhancement. Shown are axial views of contrast-enhanced T1-weighted MR as well as fused MR/PET images.</p

Additional file 4 of Differences in stem cell marker and osteopontin expression in primary and recurrent glioblastoma

Additional file 4: Figure S3. Overall survival shown by Kaplan-Meier curves for standard molecular markers. Survival was dichotomized by IDH-1/2 mutational status (A), MGMT promotor methylation status (B) and nuclear ATRX expression (C)

Comparison of ⁶⁸Ga-DOTATATE and ¹⁸F-FET in GBM.

<p>A single patient (#15) underwent both SSTR- as well as amino acid-based PET. Both modalities show highly comparable tracer uptake.</p

Additional file 2 of Differences in stem cell marker and osteopontin expression in primary and recurrent glioblastoma

Additional file 2: Figure S1. Nestin (green) and CD133 (magenta) immunofluorescence signals in representative sections of the recurrent tumor from four different patients. DAPI was used as nuclear counter stain (blue). Confocal images, maximum intensity projections, scale bar: 150 µm

Additional file 1 of Differences in stem cell marker and osteopontin expression in primary and recurrent glioblastoma

Additional file 1: Table S1. Detailed patient characteristics

Correlation between histological macrophage infiltration (visual assessment) and ⁶⁸Ga-DOTATATE uptake in three different samples of GBM.

<p>Correlation between histological macrophage infiltration (visual assessment) and ⁶⁸Ga-DOTATATE uptake in three different samples of GBM.</p

Distribution of macrophage infiltration, tumor cell burden and proliferation (visual assessment) in GBM samples.

<p>Distribution of macrophage infiltration, tumor cell burden and proliferation (visual assessment) in GBM samples.</p

Tracer distribution of ⁶⁸Ga-DOTATATE in GBM.

<p>Three examples of increased ⁶⁸Ga-DOTATATE uptake in Glioblastoma multiforme. Markedly, partly inhomogeneous tracer accumulation can be depicted in each patient. Shown are axial views of CT, SSTR-PET as well as fused PET/CT images.</p