Australian threshold quantities for ‘drug trafficking’: are they placing drug users at risk of unjustified sanction?

This study uses data on patterns of drug user consumption and purchasing to evaluate Australian legal threshold quantities to see whether Australian drug users are at risk of exceeding the thresholds for personal use alone. Introduction Drug trafficking in Australia is deemed a very serious offence, one for which legislators and courts have ruled general deterrence is paramount and ‘little mercy’ should be shown. A principal challenge has been how to effectively differentiate and sanction participants in the drug trade—particularly how to differentiate ‘traffickers’ from those who consume or purchase illicit drugs for personal use alone. To assist in this endeavour, all Australian states and territories have adopted legal thresholds that specify quantities of drugs over which offenders are either presumed to have possessed the drugs ‘for the purposes of supply’ and liable to sanction as ‘drug traffickers’ (up to 15 years imprisonment in most states), or in the case of Queensland, liable to sanctions equivalent to drug traffickers (up to 25 years imprisonment). Yet, in spite of known risks from adopting such thresholds, particularly of an unjustified conviction of a user as a trafficker, the capacity of Australian legal thresholds to deliver proportional sanctioning has been subject to limited research to date. This paper summarises key findings from a Criminology Research Grant funded project. The broader project examined this issue in two different ways—whether the thresholds are designed to filter traffickers from users and whether they enable appropriate sanctioning of traffickers of different controlled drugs. Herein, the focus is on the former—to what extent Australian legal thresholds unwittingly place users at risk of unjustified and disproportionate charge or sanction as traffickers

Does social deprivation influence inter-group contact outcomes for pupils in Northern Ireland?

The education system in Northern Ireland is characterized by division, with around 95% of the pupil population attending predominantly co-religionist schools. In a society that is transitioning from a thirty year conflict that has been framed by hostilities between the main Catholic and Protestant communities, reconciliation interventions in education have sought to promote the value of intergroup contact between pupils attending separate schools. Some qualitative research suggests that such initiatives are more likely to have positive outcomes for pupils from more middle class backgrounds than those from more disadvantaged communities and areas that experienced high levels of conflict related incidents and deaths during the pre-ceasefire years. Drawing on contact theory and empirical evidence from a large scale quantitative study, we seek to examine this theory. Using free school meals as a proxy for social class, our findings are consistent in finding that there is a differential impact of contact for those from less affluent backgrounds, and we conclude by arguing that this should be reflected in policy responses

Crime Rate Perception: An investigation into social media influence on crime rate perception and misconception

This research explored the perceptions of how crime rates have changed compared to the current perception of previous generations, whether social media has influenced those perceptions, and if those perceptions remain even when presented with current and historical data on crime rates

Dismantling the Map: Narrative, intervention and the play-response in the art of Tintin Wulia, Tita Salina and Irwan Ahmett

Play is often thought of as a light-hearted, jovial, leisurely activity we do ‘for fun’. But what happens when artists hijack these associations, and reframe the aesthetics of play? How can play (in all its various manifestations) be used in art to spotlight injustice, tell stories, and imagine a better world? Examining the practices of three contemporary artists from Indonesia – Tintin Wulia, and the artist duo of Tita Salina and Irwan Ahmett – this thesis examines how and why the artists use ideas of play for activist, interventionist and storytelling exercises. To understand the implications of using play in art, I propose an interpretive paradigm of the ‘play-response’: that is, the artists’ uses of play and performance-themed interventions as a response, dare and/or challenge to the issues confronting the world around them; using the actions of play to ‘talk back’ to authority, intervene in the status quo, and find new ways of seeing society. Works by the three artists are considered in three chapters, each dedicated to examining how activities of play are used to confront problems of the world. I analyse how the artists construct new ways of seeing issues that dominate their environment, deconstruct opaque stories by ‘playing with’ processes of reframing them, and reconstruct the possibilities of society by imagining the world as it could be. Through these acts of construction, deconstruction and reconstruction, play in art takes a variety of forms; some of which do not immediately appear to be ‘playful’, but are instead very serious modes of expression. Understanding the play-response as a distinct aesthetic ‘attitude’ and assertiveness made visible through art allows us to see how the artists have weaponised play to confront issues in the world

Caught in the conundrum: Neoliberalism and education in post-conflict Northern Ireland – Exploring shared education

Northern Ireland (NI) is emerging from a violent period in its troubled history and remains a society characterized by segregation between its two main communities. Nowhere is this more apparent than in education, where for the most part Catholic and Protestant pupils are educated separately. During the last 30 years there has been twofold pressure placed on the education system in NI – at one level to respond to intergroup tensions by promoting reconciliation, and at another, to deal with national policy demands derived from a global neoliberalist economic agenda. With reference to current efforts to promote shared education between separate schools, we explore the uneasy dynamic between a school-based reconciliation programme in a transitioning society and system-wide values that are driven by neoliberalism and its organizational manifestation – new managerialism. We argue that whilst the former seeks to promote social democratic ideals in education that can have a potentially transformative effect at the societal level, neoliberal priorities have the potential to both subvert shared education and also to embed it.</jats:p

Skeletal muscle differentiation drives a dramatic downregulation of RNA polymerase III activity and differential expression of Polr3g isoforms

Gene regulatory networks underpinning skeletal muscle determination and differentiation have been extensively investigated, providing molecular insights into how cell lineages are established during development. These studies have exclusively focused on the transcriptome downstream of RNA polymerase II (Pol II). RNA polymerase III (Pol III) drives the production of tRNAs and other small RNAs essential for the flow of genetic information from gene to protein and we have found that a specific isoform of a subunit unique to Pol III is expressed early in the myogenic lineage. This points to the possibility that additional regulatory networks exist to control the production of Pol III transcripts during skeletal muscle differentiation. We describe the differential expression of Polr3g and its alternate isoform Polr3gL during embryonic development and using a custom tRNA microarray, we demonstrate their distinct activity on the synthesis of tRNA isoacceptors. We show that Pol III dependent transcripts are dramatically down-regulated during the differentiation of skeletal muscle, as are mRNAs coding for Pol III associated proteins Brf1 and Brf2, while Polr3gL is up-regulated alongside contractile protein genes. Forcing Polr3g expression in this context results in a partial reversal of myogenic differentiatio

Skeletal muscle differentiation drives a dramatic downregulation of RNA polymerase III activity and differential expression of Polr3g isoforms

Gene regulatory networks underpinning skeletal muscle determination and differentiation have been extensively investigated, providing molecular insights into how cell lineages are established during development. These studies have exclusively focused on the transcriptome downstream of RNA polymerase II (Pol II). RNA polymerase III (Pol III) drives the production of tRNAs and other small RNAs essential for the flow of genetic information from gene to protein and we have found that a specific isoform of a subunit unique to Pol III is expressed early in the myogenic lineage. This points to the possibility that additional regulatory networks exist to control the production of Pol III transcripts during skeletal muscle differentiation. We describe the differential expression of Polr3g and its alternate isoform Polr3gL during embryonic development and using a custom tRNA microarray, we demonstrate their distinct activity on the synthesis of tRNA isoacceptors. We show that Pol III dependent transcripts are dramatically down-regulated during the differentiation of skeletal muscle, as are mRNAs coding for Pol III associated proteins Brf1 and Brf2, while Polr3gL is up-regulated alongside contractile protein genes. Forcing Polr3g expression in this context results in a partial reversal of myogenic differentiation

Sequence variation in the CD36 gene and its relationship with plasma HDL cholesterol levels

Heart disease (HD) is a primary public health concern, with HD being one of the leading causes of death every year in the United States. Many risk factors influence HD, including lipid levels, and studies have shown that higher levels of plasma high density lipoprotein (HDL) cholesterol have a protective effect against HD. Recent genome-wide linkage scans have associated a locus on chromosome 7, harboring CD36, as being involved in components of the metabolic syndrome, including HDL-C levels. Therefore, identifying variation in this gene affecting HDL-C levels is of great public health importance. The "common variant-common disease" hypothesis has been tested by a limited number of studies through common SNP genotyping with inconsistent results. To date, no studies to our knowledge have evaluated CD36 using the "rare variant-common disease" hypothesis. The aim of this study was to further evaluate the role of common and rare variation in CD36 by sequencing individuals having extremely low and high HDL-cholesterol levels in two populations, U.S. Non-Hispanic Whites (NHWs), and African Blacks. In our initial sequence analysis, 343 variants were identified in CD36, 168 of which were previously unreported in the SeattleSNPs database. According to preliminary analysis of the sequencing data, our findings support the associations of three SNPs with HDL-C levels reported in the literature. No striking difference was noticed between the distribution of rare variants between high and low HDL-C groups. We identified four common variants (MAF ≥ 5%) in our sequencing data from our small sample that displayed statistically significant differences in MAF between the low and high HDL-C groups but have not been confirmed yet by genotyping in the entire NHW and Black populations while thirteen common variants had p-values between 5-10%, which may be statistically significant due to the small sample size. To date, screening data was compiled for the entire NHWs and Black samples for a total of nineteen common variants. None of these variants displayed a significant p-value in our entire NHW and Black samples. Additional variants identified in sequencing remain to be screened in the entire NHW and Black samples

Identifying calcium-containing mineral species in the JEB Tailings Management Facility at McClean Lake, Saskatchewan

NSERCThe JEB Tailings Management Facility (TMF) is central to reducing the environmental impact of the McClean Lake uranium mill facility that is operated by AREVA Resources Canada. This facility has been designed around the idea that elements of concern (e.g., U, As, Ni, Se, Mo) will be controlled through equilibrium with precipitants. Confirming the presence of calcium-containing carbonates in the JEB TMF is the first step in determining if gypsum (CaSO4$2H2O) controls the concentration of HCO 3 (aq), limiting the formation of soluble uranyl bicarbonate complexes. A combination of X-ray diffraction (XRD), X-ray absorption near-edge spectroscopy (XANES), and microprobe X-ray fluorescence (XRF) mapping was used to analyze a series of tailings samples from the JEB TMF. Calcium carbonate in the form of calcite (CaCO3), aragonite (CaCO3), and dolomite (CaMg(CO3)2) were identified by analysing Ca K-edge m-XANES spectra coupled with microprobe XRF mapping. This is the first observation of these phases in the JEB TMF. The combination of m-XANES and XRF mapping provided a greater sensitivity to low concentration calcium species compared to the other techniques used, which were only sensitive to the major species present (e.g., gypsum)

Curiosity Killed the M-Cat: an Examination of Illicit Drugs and Media

Using mainstream media communication theories, this article outlines different mechanisms by which media can impact on public perceptions of drugs and crime. The media can set the agenda and define public interest; frame issues through selection and salience; indirectly shape individual and community attitudes towards risk and norms; and feed into political debate and decision making. We demonstrate how the media can fulfill each of these roles by examining the so-called Miaow Miaow (Mephedrone) legal high ‘epidemic’, as reported in the United Kingdom news media from 2009-2010. In doing so we illustrate that by contributing to hysteria, exerting pressure for policy change and increasing curiosity in drug use, the media can have a potentially powerful impact on demand for drugs and public perceptions of illicit drugs and drugs policy.Sydney Institute of Criminology; School of Social Sciences at the University of Western Sydne