Supplementary Figure 4 from Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men

IHC staining and quantitation of FAP in AA andEA patient samples</p

Supplementary Tables 1-3 from Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men

Clinico-pathological characteristics of PCa patiens selected for IHC and isolation of CAF. DEG genes between PrF-AA and PrF-EA</p

Supplementary Figure 3 from Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men

Differential expression of selected secreted cytokines and densitometric quantitation</p

Supplementary Figure 2 from Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men

In vitro proliferation of fibroblasts from AA and EA patients. Proliferation of PCa cell lines exposed to CM from AA and EA prostate fibroblasts</p

Supplementary Methods from Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men

Supplementary Methods</p

Supplementary Figure 1 from Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men

Assessment of collagen deposition and neoangiogenesis in PCa samples from AA and EA patients. Quantitation of IHC staining of stromal markers</p

Supplementary Figure 5 from Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men

RNASeq quality control data</p

Supplemental Tables S1-S3 from Determinants and Consequences of Arsenic Metabolism Efficiency among 4,794 Individuals: Demographics, Lifestyle, Genetics, and Toxicity

Table S1. Percentages for select baseline characteristic for 20,033 HEALS participants and subsetted based on those who have metabolite data (4794) and those who had metabolite data and were genotyped (2060). Supplemental Material, Table S2. Odds ratios and 95% confidence intervals for the association between baseline characteristics and skin lesion status (prevalent and incident (n=1,575) vs. none (n=1,780)). Supplemental Material, Table S3. Odds ratios and 95% confidence intervals for the association between quartiles of PCs and skin lesion status (prevalent+incident (n=1575) vs. none (n=1780))</p

Co-localization between HEALS DMA% association signal (rs4919687) and <i>AS3MT</i> eQTLs in the Liver.

a. We detect AS3MT eQTLs in the liver and observe evidence of co-localization (Panel A), but this evidence was not consistent across all sets of priors analyzed. The low efficiency (low DMA%) allele at rs4919687 is associated with lower AS3MT expression in the liver, though this pattern is observed more strongly in other tissue types (Panel B). (PDF)</p

In silico functional annotation of candidate causal variants of HEALS confidence set 3.

Candidate causal SNPs from HEALS confidence set 3 (lead SNP rs4919687) overlap with genomic features including candidate cis-regulatory elements and transcription factor binding sites. Highlighted panels show details of candidate causal SNPs overlapping these features.</p