Additional file 1: Table S1. of Circulating micrornas associated with glycemic impairment and progression in Asian Indians

Fold Change MicroRNA Expression. (DOCX 26 kb

Baseline predictors for vitamin E responders.

<p>Simple logistic regression models were fitted here due to small sample size, significance level is set at α<0.05.</p

The circulating levels of α-tocopherol, γ-tocopherol and γ-carboxyethylhydroxychroman (CEHC) a metabolite of vitamin E are shown at baseline (panel A) and at end of treatment (panel B) for subjects receiving vitamin E who either met histologic criteria for a response (responders) or met the criteria for non-response.

<p>CEHC was significantly lower at baseline in vitamin E treatment responders. The levels of α-, and γ-tocopherols were similar in the two groups at baseline. There was a similar enrichment of α-tocopherol in both responders and non-responders. Conversely, there was a relative de-enrichment of γ-tocopherol in both groups. These data indicate that the histologic response to vitamin E was not a simple response of the amount of vitamin E enrichment of plasma.</p

End of treatment vitamin E and placebo response biomarkers.

<p>ANCOVA models adjusting for baseline metabolites level with Tukey Method for multiple comparison.</p

Baseline and end of treatment levels of TNF- α in vitamin E responders and non-responders are shown.

<p>The baseline values in both groups are comparable. At the end of treatment, the levels significantly decreased in vitamin E responders (p = 0.002).</p

Baseline characteristics of study population.

<p>Baseline characteristics of study population.</p

Baseline and end of treatment levels of gamma glutamyl transpeptidase in vitamin E responders and non-responders are shown.

<p>The baseline values in both groups are comparable. At the end of treatment, the levels decreased in both groups but the degree of decrease was greater in vitamin E responders. This however was only a trend and not statistically significant.</p

Characteristics of two outcome groups with univariate analysis.

Characteristics of two outcome groups with univariate analysis.</p

Additional file 1: of Machine learning selected smoking-associated DNA methylation signatures that predict HIV prognosis and mortality

Table S1. Epigenome-wide significant CpG sites associated with tobacco smoking in a discovery sample. Table S2. Epigenome-wide significant CpG sites associated with tobacco smoking in a replication sample. Table S3. Machine learning selected 698 CpGs for the prediction of HIV frailty. (XLSX 77 kb

Whole exome and candidate genes associated with CD4 response group.

Whole exome and candidate genes associated with CD4 response group.</p