Total Synthesis of Landomycin A, a Potent Antitumor Angucycline Antibiotic

The first total synthesis of landomycin A, the longest and most potent antitumor angucycline antibiotic, has been achieved in 63 steps and 0.34% overall yield starting from 2,5-dihydroxybenzoic acid, 3,5-dimethylphenol, triacetyl d-glucal, and d-xylose, with a convergent linear sequence of 21 steps

Synthesis of 5-arylidene-3-(pyridin-4-yl)-2-thio-imidazolidinone derivatives with the end of flexible chain modified with aryl groups under microwave

A series of 2-thio-imidazolidinone derivatives with aryl group modifications at the end of the five-carbon side chain were synthesized. Compared with conventional heating, the target compounds were obtained in higher yield (77–95%) and shorter reaction time under the assistance of microwave heating 100 °C over 2 h.</p