39 research outputs found

    ERP results during the response selection stage.

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    <p>(A) Decision-preceding negativity amplitudes for different response types across groups. (B) Decision-preceding negativity amplitudes for different responses across regions. (C) Topographical maps of the difference between pass and play for the different wave forms in the two groups.</p

    ERP results for the choice evaluation stage.

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    <p>(A) Grand average ERP wave forms after the onset of advantageous and disadvantageous decks for the two groups. (B) The mean amplitude of different regions for advantageous and disadvantageous decks in the two groups. (C) Topographical maps of the difference between disadvantageous and advantageous decks for the different wave forms in the two groups.</p

    Knowledge of the task.

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    <p>(A) The proportion of participants who achieved conceptual knowledge between groups and across blocks. (B) The average deck rating reported every three blocks by the high group. (C)The average deck ratings reported every three blocks by the low group.</p

    Participants’ knowledge stage across trials.

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    <p>Participants’ knowledge stage across trials.</p

    Mean net score for the high and low groups across blocks.

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    <p>Mean net score for the high and low groups across blocks.</p

    Summary of cognitive processes involved in the IGT and the corresponding ERP components.

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    <p>Summary of cognitive processes involved in the IGT and the corresponding ERP components.</p

    Correlation analysis of WCST performance and ERP components.

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    <p>Correlation analysis of WCST performance and ERP components.</p

    ERP results during the feedback evaluation stage.

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    <p>(A) The effects of valence on FRN amplitude across groups. (B) FRN amplitude on three electrodes for different valences and groups. (C) The effects of group and valence on FRN amplitude. (D) Topographical maps of the difference between loss and win (loss subtract win) for the different wave forms in the two groups.</p

    Construction of Isocytosine Scaffolds via DNA-Compatible Biginelli-like Reaction

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    Herein we report a DNA-compatible Biginelli reaction to construct isocytosine scaffolds. This reaction utilizes a one-pot reaction of DNA-conjugated guanidines with aldehydes and methyl cyanoacetates to give isocytosine derivatives, and the method is well compatible with different types of substrates. This is the first report on the synthesis of an isocytosine backbone in the field of DNA-compatible organic synthesis. The successful development of this reaction can widen the chemical space of DELs

    DNA-Conjugated Cyclopropane Derivatives Constructed from Sulfonium Ylides with <i>α,β</i>-Unsaturated Ketones

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    Here, we report a DNA-compatible reaction for the generation of cyclopropane derivatives using thiolides with α,β-unsaturated ketones in the absence of transition metal and N2 protection, which is convenient for DNA encoded library (DEL) construction. This approach allows the rapid and efficient production of a series of DEL libraries of potentially biologically active cyclopropanes and spirocyclopropyl oxindole derivatives
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