PREMIUM twelve-month follow-up trial: Clinical Outcomes and Cost-effectiveness dataset from the Counselling for Alcohol Problems (CAP) RCT

The Program for Effective Mental Health Interventions in Under-Resourced Health Systems (PREMIUM) sought to develop and assess scalable psychological treatments that are culturally appropriate, affordable, and feasible for delivery by non-specialist health workers and apply these treatments to the two leading mental health disorders: moderately severe to severe depression (the Healthy Activity Program [HAP]) and harmful drinking (Counselling for Alcohol Problems [CAP]). The data collection contains records of adult male Primary Health Centres (PHC) attenders (one patient per row) recruited in the trials site between 28th October 2013 and the 30th July 2015, and followed-up for outcome assessments until 30th September 2016. It encompasses enrolment, treatment process (including therapy quality), clinical/other outcome data, and cost-effectiveness data. Only variables relevant for the analysis of our twelve-month follow-up are presented. The CAP dataset is made available on request, in accordance with ethical constraints outlined in the participant consent agreement. To obtain access, interested parties must complete a data request form or email [email protected] outlining the purpose for which they intend to use the dataset and agree to sign a licence agreement confirming that they will protect participant confidentiality

PREMIUM twelve-month follow-up trial: Clinical Outcomes and Cost-effectiveness dataset from the Healthy Activity Program (HAP) RCT

The Program for Effective Mental Health Interventions in Under-Resourced Health Systems (PREMIUM) sought to develop and assess scalable psychological treatments that are culturally appropriate, affordable, and feasible for delivery by non-specialist health workers and apply these treatments to the two leading mental health disorders: moderately severe to severe depression (the Healthy Activity Program [HAP]) and harmful drinking (Counselling for Alcohol Problems [CAP]). This data collection contains records of adult male/female Primary Health Centres (PHC) attenders (one patient per row) recruited in the trials site between October 28th 2013 and July 30th 2015, and followed-up for outcome assessments until September 30th 2016. It encompasses enrolment, treatment process (including therapy quality), cost-effectiveness, and clinical/other outcome data. Only variables relevant for the analysis of our twelve-month follow-up are presented. The HAP dataset is made available on request, in accordance with ethical constraints outlined in the participant consent agreement. To obtain access, interested parties must complete a data request form or email [email protected] outlining the purpose for which they intend to use the dataset and agree to sign a licence agreement confirming that they will protect participant confidentiality

Atroposelective Synthesis of PINAP via Dynamic Kinetic Asymmetric Transformation

The atroposelective synthesis of PINAP ligands has been accomplished via a palladium‐catalyzed C−P coupling process through dynamic kinetic asymmetric transformation. These catalytic conditions allow access to a wide variety of alkoxy‐ and benzyloxy‐substituted PINAP ligands in high enantiomeric excess. The methods described in this communication afford valuable P,N ligands in good yields and high enantioselectivity using low catalyst loading

The acceptability, feasibility and impact of a lay health counsellor delivered health promoting schools programme in India: a case study evaluation.

BACKGROUND: Studies in resource-limited settings have shown that there are constraints to the use of teachers, peers or health professionals to deliver school health promotion interventions. School health programmes delivered by trained lay health counsellors could offer a cost-effective alternative. This paper presents a case study of a multi-component school health promotion intervention in India that was delivered by lay school health counsellors, who possessed neither formal educational nor health provider qualifications. METHODS: The intervention was based on the WHO's Health Promoting Schools framework, and included health screening camps; an anonymous letter box for student questions and complaints; classroom-based life skills training; and, individual psycho-social and academic counselling for students. The intervention was delivered by a lay school health counsellor who had attained a minimum of a high school education. The counsellor was trained over four weeks and received structured supervision from health professionals working for the implementing NGO. The evaluation design was a mixed methods case study. Quantitative process indicators were collected to assess the extent to which the programme was delivered as planned (feasibility), the uptake of services (acceptability), and the number of students who received corrective health treatment (evidence of impact). Semi-structured interviews were conducted over two years with 108 stakeholders, and were analysed to identify barriers and facilitators for the programme (feasibility), evaluate acceptability, and gather evidence of positive or negative effects of the programme. RESULTS: Feasibility was established by the high reported coverage of all the targeted activities by the school health counsellor. Acceptability was indicated by a growing number of submissions to the students' anonymous letter-box; more students self-referring for counselling services over time; and, the perceived need for the programme, as expressed by principals, parents and students. A minority of teachers complained that there was inadequate information sharing about the programme and mentioned reservations about the capacities of the lay health counsellor. Preliminary evidence of the positive effects of the programme included the correction of vision problems detected in health screening camps, and qualitative evidence of changes in health-related knowledge and behaviour of students. CONCLUSION: A task-shifting approach of delegating school health promotion activities to lay school health counsellors rather than education or health professionals shows promise of effectiveness as a scalable model for promoting the health and well being of school based adolescents in resource constrained settings

A comparative SEM- EDX Analysis of Swayamagni Rasa by Dhanyarashi and Putapaka method

Introduction: Swayamagni Rasa is the herbo-mineral preparation were in, self generated heat transforms particle size from Loha Churna into Bhasma form. The present trend of preparation of Bhasma is by Putapaka method by using cow dung cakes. Here the Niragni method of Loha Marana was carried out along with the Putapaka method to Analyse the Physico-chemical changes, and are been compared with respect to its Pharmaceutical and Analytical parameters. Methods and Materials: Swayamagni Rasa was prepared according to the reference of Rasa Chintamani, other methods adopted were Shodhana of Parada, Shodhana of Ghandaka, Preparation of Dwiguna Kajjali, Samanya Shodhana, Vishesha Shodhana, Preparation of Swayamagni Loha Bhasma by Dhanyarashi and Putapaka method. Physico-chemical Analysis and Instrumental analysis was done for the samples of Swayamagni Rasa by Dhanyarashi and Putapaka method. Results: The Physico-chemical analysis of Swayamagni Rasa by Dhanyarashi and Putapaka method gave significant result. SEM-EDX of Swayamagni Rasa by Dhanyarashi, Putapaka method showed the weight and atomic percentage of elements present and its particle size. Conclusion: The samples of Swayamagni Loha Bhasma by Dhanyarashi Method and one sample of Putapaka method passed the classical Bhasma Pareeksha, that is Rekha purnatha,Varithara, Nishchandratwa and Unama. Also, elemental analysis of all these four samples of Swayamagni Rasa and sample of Putapaka shows reduction in the particle size ranging with in nanometer scale. The Niragni method of preparation of loha Bhasma pharmaceutically and Analytically showed the equivalent results. Further it can be taken up for Animal, Clinical studies to evaluate the efficacy

SEM EDX Analysis of Swayamagni Loha Bhasma

Rasashastra is a special branch of Ayurveda where in different Herbs, Mineral and Metals are used in various formulations.These metals and minerals are subjected for different purification methods to make it suitable for internal administration. The Marana is the procedure in which the purified metals or minerals are further triturated with specific drugs and subjected to heat (Puta). For various Herbs, Metals and Minerals the applications of Puta is essential to reduce the particle size for its better absorption in the body. Swayamagni Rasa is the herbo-mineral preparation were in, self generated heat transforms the particle size from Loha Churna into Bhasma form. In this study Iron fillings where used to prepare the Bhasma by subjecting it to Samanya and Vishesha Shodana and later on doing the procedure of Marana according to Rasachintamani. During the process of Shodana care has to be taken while heating the iron fillings throughout the procedure and measured quantity of liquid media for quenching has to be maintained for doing Shodana in bulk. During the process Iron fillings tend to flush over the face during each Nirvapa which has to be dealt with precaution. Thereafter analysis of the Swayamagni Rasa was analysed using SEM-EDX. It was observed that the percentage of Oxygen content in Loha Bhasma increased there by stating it to be in Oxide form and The particle size ranges around 173.3 nanometre scale which proves it being in its minutest form

Unmanned Surface Vehicles for Freighters

The purpose of this project is to study the technological and commercial feasibility of robotic control systems for freighters, and to develop a miniature proof of concept based on the findings. The research portion of the project involved a detailed technological and financial viability analysis of Unmanned Surface Vehicle (USV) technology for freight shipping, especially for inland waterways. The prototype-engineering portion of the project resulted in a proof of concept control system based on an open-source platform, which controls a miniature Unmanned Surface Vehicle prototype. The prototype is a 1.3-meter long twin-hulled catamaran, which navigates autonomously to ferry a miniature payload using differential thrust from two motors that are powered by two deep-cycle marine batteries. These undertakings have led to a comprehensive solution to enable zero emission inland freight shipping using mass-manufactured swarms of semi-autonomous, 100 DWT, low-draft, multi-hulled, solar ships that carry intermodal cargo containers

Advances in Stereoconvergent Catalysis from 2005 to 2015: Transition-Metal-Mediated Stereoablative Reactions, Dynamic Kinetic Resolutions, and Dynamic Kinetic Asymmetric Transformations

Stereoconvergent catalysis is an important subset of asymmetric synthesis that encompasses stereoablative transformations, dynamic kinetic resolutions, and dynamic kinetic asymmetric transformations. Initially, only enzymes were known to catalyze dynamic kinetic processes, but recently various synthetic catalysts have been developed. This Review summarizes major advances in nonenzymatic, transition-metal-promoted dynamic asymmetric transformations reported between 2005 and 2015