126 research outputs found

    Landscape change in the European Mountain Areas. Settlement of the Alps: evolution and trajectories

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    The increasingly fast pace of urban conversion of land over the past fifty years in Italy is a phenomenon that has caused serious damage to the national landscape. The problem concerns the whole Italy but is most serious in those areas that produce important savings thanks to the quality of their landscape. In this sense, many references in the European Landscape Convention are recognizable in the Alps that are undoubtedly one of Italy's most iconic landscapes in international perception, along with the cities of art. This paper describes the results of a research on the features of urbanization in the fifties in the Italian Alps, based on uniform historical maps of the entire country. Geostatistical surveys were conducted to determine the distribution changes of urban concentration over time and analyses were developed to point out what landscape and morphological elements have emerged, and are basically confirming greater sensitivity to land artificialization. A number of comparisons based on specific indicators were produced that show the typological and geographic variations of development taking place in the time period studied. Important information has emerged on the different territorial policies implemented by the regions over the long-term

    Dati sulla urbanizzazione italiana: verso la terza generazione

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    In this current period, several attempts to classify the “made artificial” areas are occurring and tend to identify the categories on which match the amount of adverse environmental deterioration. Today the “institutional” database does not exist in appropriate scales that can provide an o cial fact, uniform and reliable, whereas there are a number of methodologies and information from scientific sources and pseudo such

    Dysregulation of TDP-43 Intracellular Localization and Early-Onset ALS are Associated with a TARDBP S375G Variant

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    11siWe investigated the CNS and skeletal muscle tissue from a woman clinically diagnosed with amyotrophic lateral sclerosis (ALS) at the age of 22. Neuropathologic evaluation showed upper and lower motor neuron loss, corticospinal tract degeneration, and skeletal muscle denervation.Analysis of the patient's DNA revealed a AGT>GGT change resulting in a S375G substitution in the C-terminal region of TDP-43. This variant was previously reported as being benign. Considering the early onset and severity of the disease in this patient, we tested the effects of this genetic variant on TDP-43 localization, pre-mRNA splicing activity, and toxicity, in parallel with the effects on known neighboring disease-associated mutations. In cell lines, expressed in culture, S375G TDP-43 appeared to be more significantly localized in the nucleus and to exert higher toxicity than wild-type TDP-43. Strikingly, a phosphomimic mutant at the same residue (S375E) showed a strong tendency to accumulate in the cytoplasm, especially under stress conditions, and molecular dynamics simulations suggest that phosphorylation of this residue can disrupt TDP-43 intermolecular interactions. The results of the current study highlight the importance of phosphorylation and regulation of TDP-43 nuclear-cytoplasmic shuttling/redistribution, in relation to the pathogenetic mechanisms involved in different forms of ALS. This article is protected by copyright. All rights reserved.partially_openopenNewell, Kathy; Paron, Francesca; Mompean, Miguel; Murrell, Jill; Salis, Elisa; Stuani, Cristiana; Pattee, Gary; Romano, Maurizio; Laurents, Douglas; Ghetti, Bernardino; Buratti, EmanueleNewell, Kathy; Paron, Francesca; Mompean, Miguel; Murrell, Jill; Salis, Elisa; Stuani, Cristiana; Pattee, Gary; Romano, Maurizio; Laurents, Douglas; Ghetti, Bernardino; Buratti, Emanuel

    Gli stati e le dinamiche dei processi insediativi e infrastrutturali di trasformazione dei suoli in Italia

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    In the last 50 years urban land conversion had an evident and undeniable acceleration. Nowadays it's not possible giving the reliable measurement of the state due to a chronic lack of knowledge at every territorial level, from the national to the municipal. The major problem is the absence of a clean border between urbanized areas and countryside, unlike other northern European Countries. This paper present the results in progress of the research about urban increasing in Italian regions in the last mid century. Several statistical elaboration show some effect and trends on landscape structure

    Alteración de la función renal: prevalencia y factores asociados en pacientes de riesgo

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    Introduction: Chronic kidney disease (CKD) does not have any clinical symptoms in the early stages and, therefore, most people only attend healthcare units when they are already in the terminal phase of the disease, which is still common in Brazil. Objective: To identify the prevalence of altered estimated glomerular filtration rate (eGFR) and associated factors in users of the unified health system suffering from diabetes mellitus and/or systemic hypertension at high risk of cardiovascular disease. Materials and Methods: A cross-sectional study was conducted based on the medical records of 331 users attending the State Specialty Care Center located in the west-central region of Minas Gerais, Brazil between September 2017 and June 2019. A descriptive univariate analysis and multivariate logistic regression were performed. Results: A total of 118 (35.6%) of the participants had altered eGFR. A significant association between altered eGFR and age was identified: older people  ≥ 60 years old were 5.53 times more likely to have altered eGFR. Participants using polypharmacy were 2.64 times more likely to have altered eGFR. Discussion: In line with similar studies, a lack of follow-up on the initiation and development of CKD in the early stages was identified, implying a late approach and limited actions to preserve kidney function. Conclusions: A high prevalence of altered eGFR was identified (35.6%) with no records in the tables that could lead to a preventive approach to impaired kidney function. Advanced age and polypharmacy were identified as independent variables in the alteration of kidney function. How to cite this article: Castro, Tássia Lima Bernardino; Oliveira, Rayane Hellen; Sousa, João Antônio Gomides; Romano, Márcia Christina Caetano; Guedes, João Victor Marques; Otoni, Alba. Função renal alterada: prevalência e fatores associados em pacientes de risco. Revista Cuidarte. 2020; 11(2): e1019. http://dx.doi.org/10.15649/cuidarte.1019Introdução: a doença renal crônica (DRC) nos estágios iniciais não apresenta manifestações clínicas e, por isso, as pessoas somente procuram as unidades de saúde já na fase terminal da doença. Isso ainda é uma rotina no Brasil. Objetivo: identificar a prevalência de taxa de filtração glomerular estimada (TFGe) alterada e fatores associados em usuários do sistema único de saúde com Diabetes Mellitus e/ou com Hipertensão Arterial Sistêmica de alto e muito alto risco para doença cardiovascular. Materiais e Métodos: estudo transversal com prontuários de 331 usuários do Centro Estadual de Atenção Especializada no Centro-Oeste mineiro/ Minas Gerais/ Brasil, entre setembro de 2017 a junho de 2019. Realizou-se análise descritiva, univariada e regressão logística multivariada. Resultados: do total de participantes, 118 (35,6%) tiveram TFGe alterada. Identificou-se associação significativa da TFGe alterada com a idade: idosos ≥ 60 anos apresentaram 5,53 vezes mais chance de ter a TFGe alterada. Os participantes em uso da polifarmácia tiveram 2,64 vezes mais chance de terem a TFGe alterada. Discussão: em analogia com estudos semelhantes, registrou-se a ausência de acompanhamento da instalação e desenvolvimento da DRC nas fases iniciais, implicando em abordagem tardia e ações limitadas para preservação das funções renais. Conclusões: identificou-se alta prevalência de TFGe alterada (35,6%), sem registros nos prontuários que pudessem direcionar uma abordagem preventiva da degeneração das funções renais. A idade avançada e polifarmácia foram identificadas como variáveis independentes para alteração da função renal. Como citar este artigo: Castro, Tássia Lima Bernardino; Oliveira, Rayane Hellen; Sousa, João Antônio Gomides; Romano, Márcia Christina Caetano; Guedes, João Victor Marques; Otoni, Alba. Função renal alterada: prevalência e fatores associados em pacientes de risco. Revista Cuidarte. 2020; 11(2): e1019. http://dx.doi.org/10.15649/cuidarte.1019Introducción: La enfermedad renal crónica (ERC) en sus primeras etapas no presenta manifestaciones clínicas y, por lo tanto, la mayoría de las personas solo se acercan a las unidades de salud cuando ya están en la fase terminal de la enfermedad, lo cual sigue siendo habitual en Brasil. Objetivo: Identificar la prevalencia de la tasa estimada de filtración glomerular (TFG) alterada y los factores asociados en usuarios del sistema de salud único que sufran de diabetes mellitus y/o hipertensión sistémica de alto riesgo de enfermedad cardiovascular. Materiales y métodos: Se realizó un estudio transversal con las historias clínicas de 331 usuarios del Centro Estatal de Atención Especializada ubicado en el centro oeste de Minas Gerais, Brasil entre septiembre de 2017 y junio de 2019. Se realizaron un análisis univariado descriptivo y una regresión logística multivariante. Resultados: Del total de participantes, 118 (35,6%) tenían la TFG alterada. Se identificó una asociación significativa entre la alteración de la TFG y la edad: los ancianos ≥ 60 años tenían 5,53 veces más posibilidades de tener la TFG alterada. Los participantes que utilizaron la polifarmacia tenían 2,64 veces más probabilidades de que se alterara la TFG. Discusión: En consonancia con estudios similares, se registró la falta de seguimiento del inicio y el desarrollo de la ERC en las primeras etapas, lo que implica un enfoque tardío y acciones limitadas para preservar las funciones renales. Conclusiones: Se identificó una alta prevalencia de TFG alterada (35,6%) sin registros en las tablas que pudieran conducir a un enfoque preventivo de la degeneración de la función renal. La edad avanzada y la polifarmacia se identificaron como variables independientes en la alteración de la función renal. Como citar este artículo: Castro, Tássia Lima Bernardino; Oliveira, Rayane Hellen; Sousa, João Antônio Gomides; Romano, Márcia Christina Caetano; Guedes,Guedes, João Victor Marques; Otoni, Alba. Função renal alterada: prevalência e fatores associados em pacientes de risco. Revista Cuidarte. 2020; 11(2): e1019. http://dx.doi.org/10.15649/cuidarte.101

    Performance and Operation of the CMS Electromagnetic Calorimeter

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    The operation and general performance of the CMS electromagnetic calorimeter using cosmic-ray muons are described. These muons were recorded after the closure of the CMS detector in late 2008. The calorimeter is made of lead tungstate crystals and the overall status of the 75848 channels corresponding to the barrel and endcap detectors is reported. The stability of crucial operational parameters, such as high voltage, temperature and electronic noise, is summarised and the performance of the light monitoring system is presented
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