New holiday towns as Non-places: the case of Marina d'Or

Since the start of tourism as rewarding and massive activity in the mid-nineteenth century, new tourist destinations have appeared to satisfy mass tourism. Among the different urban developments that have taken place so far, the objective of this paper is to reflect on a model of tourist development that is spreading internationally, the New holiday towns. These urban settlements can reach large dimensions in size and population, so producing appreciable economic, political and environmental impacts in their environment. But, what about the social impact that these NHTs involve? Tthrough the analysis of a specific case, Marina d’Or, social aspects were investigated with the help of a quantitative method, the Survey: prototype users; frequency by residents in town; relations with its neighbors; intensity of use that they make of public space and their satisfaction and valuation of urban space. And finally with a qualitative methodology, the Participant Observation, the diversity of its urban space and the ways of inhabiting it were analyzed.Peer Reviewe

New holiday towns as Non-places: the case of Marina d'Or

Since the start of tourism as rewarding and massive activity in the mid-nineteenth century, new tourist destinations have appeared to satisfy mass tourism. Among the different urban developments that have taken place so far, the objective of this paper is to reflect on a model of tourist development that is spreading internationally, the New holiday towns. These urban settlements can reach large dimensions in size and population, so producing appreciable economic, political and environmental impacts in their environment. But, what about the social impact that these NHTs involve? Tthrough the analysis of a specific case, Marina d’Or, social aspects were investigated with the help of a quantitative method, the Survey: prototype users; frequency by residents in town; relations with its neighbors; intensity of use that they make of public space and their satisfaction and valuation of urban space. And finally with a qualitative methodology, the Participant Observation, the diversity of its urban space and the ways of inhabiting it were analyzed.Peer Reviewe

The impact of tourism activity on the land consumption: the case of Catalonia

The Spanish Mediterranean coast has shown, since the rise of tourism as a major economic activity, being one of the geographic areas with higher growth dynamics of developed land. Proof of this is the high percentage of land occupation that has taken place in the first 500m of the coast, with up to 40%. This current situation has driven this study, aiming to find out what has been the involvement of tourism activity in land consumption. That is, how it affects the continuity, fragmentation, density and land use of urban growth patterns on the coastline and what is its level of impact, depending on the distance of these urban systems from the coastline. The result suggests that the influence of tourism on the spatial distribution favors urban sprawl, being location one of the most important forces.Peer Reviewe

What About Passion in Education? The Concept of Passion, why it is Important and How Teachers Can Promote it

Is passion important in the educational context? What are the benefits of passion? Is it possible to foster students’ passion? What are the teachers’ characteristics or behaviors that foster students’ passion? The aim of this study was to answer this questions by a literature review, as well as to present a global and current picture about the role of passion in Education. Although research on passion is really recent and, therefore, still scarce, the literature reviewed showed a great variety of passion’s outcomes, which highlights the importance it has in the educational context. We also tried to summarize the teachers’ characteristics studied up to now that can foster the students’ passion. We concluded by presenting the potential implications of the articles reviewed within education, and presenting the main conclusions of the review

The Effect of Moderate- Versus High-Intensity Resistance Training on Systemic Redox State and DNA Damage in Healthy Older Women

This study investigated effects of a 16-week progressive resistance training program (RTP) with elastic bands at two different intensities on systemic redox state, DNA damage, and physical function in healthy older women. METHODS: Participants were randomly assigned to the high-intensity group (HIGH; n = 39), moderate-intensity group (MOD; n = 31), or control group (CG; n = 23). The exercise groups performed an RTP twice a week with three to four sets of 6 (HIGH) or 15 (MOD) repetitions of six overall body exercises at a perceived exertion rate of 8-9 on the OMNI-Resistance Exercise Scale for use with elastic bands. Thiol redox state was determined by reduced glutathione (GSH), oxidized glutathione (GSSG), and GSSG/GSH in blood mononuclear cells. Degree of DNA damage was assessed by presence of the oxidized DNA base molecule 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-OHdG) in urine. Physical function monitoring was based on the arm curl, chair stand, up and go, and 6-min walk tests. RESULTS: The HIGH group showed a significant increase in 8-OHdG (+71.07%, effect size [ES] = 1.12) and a significant decrease in GSH (-10.91, ES = -0.69), while the MOD group showed a significant decrease in 8-OHdG levels (-25.66%, ES = -0.69) with no changes in thiol redox state. GSH levels differed significantly between the HIGH and CG groups posttest. The exercise groups showed significant improvements in physical function with no differences between groups. CONCLUSION: RTP at a moderate rather than high intensity may be a better strategy to reduce DNA damage in healthy older women while also increasing independence

Little Brains

En el siguiente trabajo de investigación se han identificado los factores para el funcionamiento de una start up digital, basado en el servicio de talleres virtuales a niños entre 6 y 12 años. En la actualidad, el mundo entero y nuestro país, Perú, están atravesando una crisis sanitaria, debido a la propagación del COVID-19, lo cual desencadenó que como medida de seguridad se establezca la prohibición de algunas actividades, como las clases presenciales. De acuerdo con la coyuntura se origina Little Brains, plataforma virtual que brinda siete talleres individuales y familiares, para niños de 6 a 12 años, quienes dentro de su tiempo libre busquen nuevas opciones para disfrutar de este y puedan disminuir con los niveles de sedentarismo. El proyecto se realizará mediante talleres personalizados, donde se ofrecerá que el usuario aprenda a un ritmo adecuado y disfrute de su tiempo libre. Para poder identificar a los clientes potenciales, se realizaron cuatro experimentos en sus redes sociales y Landing Page, a través de publicaciones y campañas publicitarias donde se brindó información referente a los talleres, precios y métodos de pago para poder obtener posibles clientes, y completar el proceso de compra. Finalmente, se evaluaron los presupuestos asignados como inversión para que la empresa pueda entrar en funcionamiento y datos estimados de ingresos, de manera que con esta información se logre evaluar si la empresa en los próximos tres años sería rentable. También, los métodos de financiamiento que serán tomados por nosotros para poner el negocio en marcha.In the following research work, the factors for the operation of a digital start-up have been identified, based on the service of virtual workshops for children between 6 and 12 years old. Currently, the whole world and our country, Peru, are going through a health crisis, due to the spread of COVID-19, which triggered the prohibition of some activities, such as face-to-face classes, as a security measure. According to the situation, Little Brains originates, a virtual platform that offers seven individual and family workshops, for children from 6 to 12 years old, who, in their free time, seek new options to enjoy this and may decrease with the levels of sedentary lifestyle. The project will be carried out through personalized workshops, where the user will be offered to learn at an appropriate pace and enjoy their free time. To identify potential customers, four experiments were carried out on their social networks and Landing Page, through publications and advertising campaigns where information regarding the workshops, prices and payment methods was provided to obtain potential customers and complete the purchasing process. Finally, the budgets assigned as investment were evaluated so that the company can start operating and estimated income data, so that with this information it is possible to evaluate whether the company in the next three years would be profitable. Also, the financing methods that will be taken by us to start the business.Trabajo de investigació

Evaluation of different bowel preparations for small bowel capsule endoscopy: a prospective, randomized, controlled study

To obtain an adequate view of the whole small intestine during capsule endoscopy (CE) a clear liquid diet and overnight fasting is recommended. However, intestinal content can hamper vision in spite of these measures. Our aim was to evaluate tolerance and degree of intestinal cleanliness during CE following three types of bowel preparation. PATIENTS AND METHODS: This was a prospective, multicenter, randomized, controlled study. Two-hundred ninety-one patients underwent one of the following preparations: 4 L of clear liquids (CL) (group A; 92 patients); 90 mL of aqueous sodium phosphate (group B; 89 patients); or 4 L of a polyethylene glycol electrolyte solution (group C; 92 patients). The degree of cleanliness of the small bowel was classified by blinded examiners according to four categories (excellent, good, fair or poor). The degree of patient satisfaction, gastric and small bowel transit times, and diagnostic yield were measured. RESULTS: The degree of cleanliness did not differ significantly between the groups (P = 0.496). Interobserver concordance was fair (k = 0.38). No significant differences were detected between the diagnostic yields of the CE (P = 0.601). Gastric transit time was 35.7 +/- 3.7 min (group A), 46.1 +/- 8.6 min (group B) and 34.6 +/- 5.0 min (group C) (P = 0.417). Small-intestinal transit time was 276.9 +/- 10.7 min (group A), 249.7 +/- 13.1 min (group B) and 245.6 +/- 11.6 min (group C) (P = 0.120). CL was the best tolerated preparation. Compliance with the bowel preparation regimen was lowest in group C (P = 0.008). CONCLUSIONS: A clear liquid diet and overnight fasting is sufficient to achieve an adequate level of cleanliness and is better tolerated by patients than other forms of preparation

Benchmarking of Whole Exome Sequencing and Ad Hoc Designed Panels for Genetic Testing of Hereditary Cancer

Acknowledgements: We thank all patients who contributed to this study. The work was supported by grants from the Instituto de Salud Carlos III (ISCIII, MINECO) (operating grants: PI13/00285 and RD12/0036/0008 awarded to C.L. and PIE13/00022 and RD12/0036/0031 awarded to G.C.) and confunded by FEDER funds/European Regional Development Fund (ERDF) - a way to Build Europe-"// FONDOS FEDER "una manera de hacer Europa", the Generalitat de Catalunya (Government of Catalonia) (operating grant 2014SGR338, awarded to G.C.) and the Asociación Española Contra el Cáncer (operating grants, 2010 Grupos Estables, awarded to G.C.). J.B. received a Spanish Society of Medical Oncology grant. This activity is sponsored by the ISCIII Ministerio de Economía y Competitividad (PT13/0001/0044).Next generation sequencing panels have been developed for hereditary cancer, although there is some debate about their cost-effectiveness compared to exome sequencing. The performance of two panels is compared to exome sequencing. Twenty-four patients were selected: ten with identified mutations (control set) and fourteen suspicious of hereditary cancer but with no mutation (discovery set). TruSight Cancer (94 genes) and a custom panel (122 genes) were assessed alongside exome sequencing. Eightythree genes were targeted by the two panels and exome sequencing. More than 99% of bases had a read depth of over 30x in the panels, whereas exome sequencing covered 94%. Variant calling with standard settings identified the 10 mutations in the control set, with the exception of MSH6 c.255dupC using TruSight Cancer. In the discovery set, 240 unique non-silent coding and canonic splice-site variants were identified in the panel genes, 7 of them putatively pathogenic (in ATM, BARD1, CHEK2, ERCC3, FANCL, FANCM, MSH2). The three approaches identified a similar number of variants in the shared genes. Exomes were more expensive than panels but provided additional data. In terms of cost and depth, panels are a suitable option for genetic diagnostics, although exomes also identify variants in non-targeted genes

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe