143 research outputs found

    A Review on Recent Advancements of Graphene and Graphene-Related Materials in Biological Applications

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    Graphene is the most outstanding material among the new nanostructured carbonaceous species discovered and produced. Graphene’s astonishing properties (i.e., electronic conductivity, mechanical robustness, large surface area) have led to a deep change in the material science field. In this review, after a brief overview of the main characteristics of graphene and related materials, we present an extensive overview of the most recent achievements in biological uses of graphene and related materials

    Alternative Nuclear Imaging Tools for Infection Imaging

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    Purpose of Review Cardiovascular infections are serious disease associated with high morbidity and mortality. Their diagnosis is challenging, requiring a proper management for a prompt recognition of the clinical manifestations, and a multidisciplinary approach involving cardiologists, cardiothoracic surgeons, infectious diseases specialist, imagers, and microbiologists. Imaging plays a central role in the diagnostic workout, including molecular imaging techniques. In this setting, two different strategies might be used to image infections: the first is based on the use of agents targeting the microorganism responsible for the infection. Alternatively, we can target the components of the pathophysiological changes of the inflammatory process and/or the host response to the infectious pathogen can be considered. Understanding the strength and limitations of each strategy is crucial to select the most appropriate imaging tool. Recent Findings Currently, multislice computed tomography (MSCT) and nuclear imaging (F-18-fluorodeoxyglucose positron emission tomography/computed tomography, and leucocyte scintigraphy) are part of the diagnostic strategies. The main role of nuclear medicine imaging (PET/CT and SPECT/CT) is the confirmation of valve/CIED involvement and/or associated perivalvular infection and the detection of distant septic embolism. Proper patients' preparation, imaging acquisition, and reconstruction as well as imaging reading are crucial to maximize the diagnostic information. In this manuscript, we described the use of molecular imaging techniques, in particular WBC imaging, in patients with infective endocarditis, cardiovascular implantable electronic device infections, and infections of composite aortic graft, underlying the strength and limitations of such approached as compared to the other imaging modalities

    Prosthetic Valve Endocarditis

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    Prosthetic valve infective endocarditis (PVE) is associated with high morbidity and mortality. With the increasing number of prostheses implanted every year, the incidence of PVE is expected to rise. The diagnosis of PVE is challenging as blood cultures are often negative and the sensitivity of echocardiography is suboptimal in the presence of prosthetic valves. In 2015, the European Society of Cardiology introduced 18F-fluorodeoxyglucose–positron emission tomography/computed tomography (FDG-PET/CT) as a major criterion for the diagnosis of PVE, based on its ability to identify valve infection and to detect septic emboli. In addition, FDG-PET/CT can detect PVE portal of entry, which may lead to change in management. This chapter will discuss the epidemiology and clinical presentations of PVE. In addition, the role of FDG-PET/CT in PVE as well as optimal imaging protocols will be reviewed.</p

    Music and Second Language: A Case Study about Primary Education Students’ Perceptions of Relations and Similarities between both Areas

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    [Resumen] Este estudio tiene su origen en un proyecto de investigación e innovación docente titulado iPlay School of Music and Languages, participado por el Grupo de Investigación HUM-1006, Trinity College España-Portugal, y la Delegación Territorial de Educación, Deporte, Igualdad, Políticas Sociales y Conciliación de Córdoba (España), que consiste en la impartición de clases de música teórica e instrumental (clases de guitarra grupales) en inglés. El objetivo de este estudio es indagar en la relación entre el aprendizaje de la música y de la segunda lengua (inglés) a través de un cuestionario distribuido entre 41 estudiantes de entre 9 y 10 años de edad, de los que 24 habían participado durante un año en el mencionado proyecto, mientras que los demás alumnos estudiaban inglés en el colegio siguiendo el currículo escolar. En la encuesta se interroga a los sujetos sobre sus percepciones acerca del aprendizaje de la música y de la segunda lengua (L2) en torno a aspectos como procesamiento y elementos constitutivos. El objetivo de esta investigación consiste en indagar acerca de los beneficios que el aprendizaje de la música puede aportar al aprendizaje de una lengua extranjera Los resultados confirman que el entrenamiento musical ayuda al aprendizaje de la L2, y sugieren que es conveniente profundizar en esta investigación para descubrir mediante qué tipo de metodología el aprendizaje de la música puede beneficiar el de la L2, lo que puede conllevar una mejora en el aprendizaje de ambas disciplinas para la extrapolación de los resultados a prácticas de aula[Abstract] This study arises from a research and teaching innovation project entitled iPlay School of Music and Languages, organised by the Research Group HUM-1006, Trinity College Spain-Portugal, and the Territorial Delegation of Education, Sport, Equality and Social Policies of Cordoba (Spain), which consists of teaching theoretical and instrumental music lessons (group guitar classes) by using English as a second language (L2). The main aim of this study is to investigate the relationship between music and second language learning by means of a questionnaire distributed among 41 students aged between 9 and 10 years old, 24 of whom had participated in the project for one year, while the other students were studying English at school, following the school curriculum. In the survey, the subjects were asked about their perceptions of music and second language learning in terms of processing and constituent elements. The purpose of this study is to investigate about the benefits that music learning could provide to foreign language learning. The results confirm that music training helps foreign language learning, and suggest that further research is needed to find out what kind of methodology music learning can benefit second learning, which can lead to an improvement in the learning of both disciplines in order to extrapolate the results to classroom practice

    The Relationship between Music and Second Languages. La relación entre música y segunda lengua

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    This study stems from a research and teaching innovation project entitled iPlay School of Music and Languages, in collaboration with the HUM-1006 Research Group, Trinity College Spain-Portugal, and the Territorial Delegation of Education, Sport, Equality and Social Policies of Cordoba, which provides for the teaching of theoretical and instrumental music classes in English. The aim of this study is to find out whether exists a relationship between music learning and second languages learning by means of a questionnaire distributed among 32 students aged between 7 and 9 years old on the participants’ taste for these two disciplines, their practice and study habits and their skills and abilities in both areas. The results confirm the existence of such a relationship and our conclusions indicate that further research is desirable to discover how the two processes can benefit from each other, with the aim of enhancing both music and second language learning.El presente estudio nace de un proyecto de investigación e innovación docente titulado iPlay School of Music and Languages, participado por el Grupo de Investigación HUM-1006, Trinity College España-Portugal, y la Delegación Territorial de Educación, Deporte, Igualdad, Políticas Sociales y Conciliación de Córdoba, que prevé la impartición de clases de música teórica e instrumental en inglés. El objetivo de este estudio es indagar sobre la existencia de una relación entre música y segunda lengua a través de un cuestionario distribuido entre 32 estudiantes de entre 7 y 9 años de edad sobre el gusto de los participantes, sus hábitos de práctica y estudio, y las capacidades en ambos ámbitos. Los resultados confirman la existencia de tal relación y las conclusiones indican que es conveniente profundizar en la investigación para descubrir de qué manera los dos procesamientos pueden beneficiarse mutuamente, con el objetivo de potenciar el aprendizaje en ambas areas

    Elevated lipoprotein(a) as a predictor for coronary events in older men

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    Elevated circulating lipoprotein (a) [Lp(a)] is associated with an increased risk of first and recurrent cardiovascular events; however, the effect of baseline Lp(a) levels on long-term outcomes in an elderly population is not well understood. The current single-center prospective study evaluated the association of Lp(a) levels with incident acute coronary syndrome to identify populations at risk of future events. Lp(a) concentration was assessed in 755 individuals (mean age of 71.9 years) within the community and followed for up to 8 years (median time to event, 4.5 years; interquartile range, 2.5–6.5 years). Participants with clinically relevant high levels of Lp(a) (>50 mg/dl) had an increased absolute incidence rate of ASC of 2.00 (95% CI, 1.0041) over 8 years (P = 0.04). Moreover, Kaplan-Meier cumulative event analyses demonstrated the risk of ASC increased when compared with patients with low (<30 mg/dl) and elevated (30–50 mg/dl) levels of Lp(a) over 8 years (Gray’s test; P = 0.16). Within analyses adjusted for age and BMI, the hazard ratio was 2.04 (95% CI, 1.0–4.2; P = 0.05) in the high versus low Lp(a) groups. Overall, this study adds support for recent guidelines recommending a one-time measurement of Lp(a) levels in cardiovascular risk assessment to identify subpopulations at risk and underscores the potential utility of this marker even among older individuals at a time when potent Lp(a)-lowering agents are undergoing evaluation for clinical use

    HERG1 positivity and Glut-1 negativity identifies high-risk TNM stage I and II colorectal cancer patients, regardless of adjuvant chemotherapy

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    BACKGROUND: The identification of early-stage colorectal cancer (CRC) with high risk of progression is one major clinical challenge, mainly due to lack of validated biomarkers. The aims of the present study were to analyze the prognostic impact of three molecular markers belonging to the ion channels and transporters family: the ether-à-go-go-related gene 1 (hERG1) and the calcium-activated KCa3.1 potassium channels, as well as the glucose transporter 1 (Glut-1); and to define the impact of adjuvant chemotherapy in conjunction with the abovementioned biomarkers, in a cohort of radically resected stage I–III CRC patients. PATIENTS AND METHODS: The expressions of hERG1, KCa3.1, and Glut-1 were tested by immunohistochemistry on 162 surgical samples of nonmetastatic, stage I–III CRC patients. The median follow-up was 32 months. The association between biological markers, clinicopathological features, and survival outcomes was investigated by evaluating both disease-free survival and overall survival. RESULTS: Although no prognostic valence emerged for KCa3.1, evidence of a negative impact of hERG1 expression on survival outcomes was provided. On the contrary, Glut-1 expression had a positive impact. According to the results of the multivariate analysis, patients were stratified in four risk groups, based on TNM stage and hERG1/Glut-1 expression. After adjusting for adjuvant therapy, stage I and II, Glut-1-negative, and hERG1-positive patients showed the worst survival experience. CONCLUSION: This study strongly indicates that the combination of hERG1 positivity and Glut-1 negativity behaves as a prognostic biomarker in radically resected CRC patients. This combination identifies a group of stage I and II CRC patients with a bad prognosis, even worse than that of stage III patients, regardless of adjuvant therapy accomplishment
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