Water rights and multiple water uses: framework and application to Kirindi Oya irrigation system, Sri Lanka

The growing attention to water rights in recent years reflects the increasing scarcity and competition for this vital resource. Because rights are at the heart of any water allocation system, they are also critical for any reallocation. Not only efficiency, but also fundamental issues of equity are at stake. To understand water rights requires going beyond formal statutory law (which may or may not be followed), to look at the many bases for claiming water. Because of the vital nature of this resource, state law, religious law, customary law and local norms all have something to say in defining water rights. The delineation of water rights is further complicated when we take into consideration multiple uses (irrigation, domestic, fishing, livestock, industries, etc.) as well as multiple users (different villages, groups of farmers in the head and tail, fishermen, cattle owners, etc.) of the resource. These overlapping uses bring in different government agencies, as well as different sets of norms and rules related to water. This paper provides a framework for examining the statutory and customary water rights of multiple users of water and applies it in the Kirindi Oya irrigation system in Sri Lanka, based on a multidisciplinary study conducted in 1997-1998. It demonstrates that the range of stakeholders with an interest in water resources of an irrigation system go far beyond the owners and cultivators of irrigated fields. As such, these groups are not only claimants on the ongoing management of water resource systems, but also need to be included in any considerations of transferring water from irrigation to other uses.Water rights., Water resources., Water use Sri Lanka Case studies., Irrigation projects Sri Lanka.,

Peroxidized docosahexaenoic acid causes RPE dysfunction: implications for retinal ageing and AMD

The aim of this study was to gain important insights into the effects of peroxidized docosahexaenoic acid (pDHA) on the retinal pigment epithelium (RPE), and whether its effects can cause RPE cell dysfunction in a way similar to that observed in retinal ageing and the pathogenesis of age-related macular degeneration (AMD). Initially, the time-course of in vitro peroxidation of DHA was monitored, culminating in formation of products able to absorb light above 400 nm. Cultured RPE cells were then exposed to this pDHA, which was shown to be toxic, both in dark and light-exposed conditions. Various cell viability assays were carried out indicating RPE cell death after exposure to pDHA is likely to occur by apoptosis. The effects of pDHA were reduced in the presence of various agents - a-tocopherol, glutathione, N-acetylcysteine, and phosphatidylethanolamine (PE). Measurements of singlet oxygen, transient and superoxide production were carried out to determine the photosensitizing properties of pDHA. The ability of PE to reduce the production of these species was investigated but it was shown to have no effect on their yield, although singlet oxygen lifetime was reduced. Finally, lysosomal enzyme activity, lysosomal integrity and accumulation of fluorescent and undegraded material were monitored after exposure to pDHA, demonstrating that pDHA was able to disrupt the ability of the RPE to fully degrade phagocytosed material. In summary, pDHA is able to affect RPE cell viability directly when exposed extracellularly, and can also affect essential normal functions of the RPE intracellularly. In conjunction with published findings that pDHA is present in the retina - both within and around the RPE - the data presented here support the theory that pDHA can play an important role in causing RPE dysfunction, resulting in a loss of the protective role these cells play for photoreceptors, as occurs in retinal ageing and AMD

Biopsy prostate cancer perineural invasion and tumour load are associated with positive posterolateral margins at radical prostatectomy:implications for planning of nerve-sparing surgery

Aims: Radical prostatectomy (RP) for prostate cancer is frequently complicated by erectile dysfunction and urinary incontinence. However, sparing of the nerve bundles adjacent to the posterolateral sides of the prostate reduces the number of complications at the risk of positive surgical margins. Preoperative selection of men eligible for safe, nerve-sparing surgery is therefore needed. Our aim was to identify pathological factors associated with positive posterolateral surgical margins in men undergoing bilateral nerve-sparing RP. Methods and results: Prostate cancer patients undergoing RP with standardised intra-operative surgical margin assessment according to the NeuroSAFE technique were included. Preoperative biopsies were reviewed for grade group (GG), cribriform and/or intraductal carcinoma (CR/IDC), perineural invasion (PNI), cumulative tumour length and extraprostatic extension (EPE). Of 624 included patients, 573 (91.8%) received NeuroSAFE bilaterally and 51 (8.2%) unilaterally, resulting in a total of 1197 intraoperative posterolateral surgical margin assessments. Side-specific biopsy findings were correlated to ipsilateral NeuroSAFE outcome. Higher biopsy GG, CR/IDC, PNI, EPE, number of positive biopsies and cumulative tumour length were all associated with positive posterolateral margins. In multivariable bivariate logistic regression, ipsilateral PNI [odds ratio (OR) = 2.98, 95% confidence interval (CI) = 1.62–5.48; P &lt; 0.001] and percentage of positive cores (OR = 1.18, 95% CI = 1.08–1.29; P &lt; 0.001) were significant predictors for a positive posterolateral margin, while GG and CR/IDC were not. Conclusions: Ipsilateral PNI and percentage of positive cores were significant predictors for a positive posterolateral surgical margin at RP. Biopsy PNI and tumour volume can therefore support clinical decision-making on the level of nerve-sparing surgery in prostate cancer patients.</p

Urinary Incontinence and Sexual Function After the Introduction of NeuroSAFE in Radical Prostatectomy for Prostate Cancer

Background: Nerve-sparing (NS) radical prostatectomy (RP) results in better functional outcomes. Intraoperative neurovascular structure–adjacent frozen section examination (NeuroSAFE) significantly increases the frequency of NS surgery. The effect of NeuroSAFE on postoperative erectile function (EF) and continence is not yet clear. Objective: To describe EF and continence outcomes for men undergoing RP with the NeuroSAFE technique. Design, setting, and participants: Between September 2018 and February 2021, 1034 men underwent robot-assisted RP. Data for patient-reported outcomes were collected via validated questionnaires. Intervention: NeuroSAFE technique for RP. Outcome measurements and statistical analysis: Continence was assessed using the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) or Expanded Prostate Cancer Index Composite short form (EPIC-26) and defined as use of 0–1 pads/d. EF was evaluated using EPIC-26 or the International Index of Erectile Function short form (IIEF-5), with data converted according to the Vertosick method and categorized. Descriptive statistics were used to asses and describe tumor characteristics and continence and EF outcomes. Results and limitations: Of the 1034 men who underwent RP after introduction of the NeuroSAFE technique, 63% and 60% completed a preoperative and at least one postoperative questionnaire on continence and EF, respectively. Of the men who underwent unilateral or bilateral NS surgery, use of 0–1 pads/d was reported by 93% after 1 yr and 96% after 2 yr; the corresponding rates for men who underwent non-NS surgery were 86% and 78%. Overall, use of 0–1 pads/d was reported by 92% of the men at 1 yr and by 94% at 2 yr after RP. Men in the NS group had a good or intermediate Vertosick score after RP more often than the non-NS group. Overall, 44% of the men had a good or intermediate Vertosick score at 1 and 2 yr after RP. Conclusions: After introduction of the NeuroSAFE technique, the continence rate was 92% at 1 yr and 94% at 2 yr after RP. The NS group had a greater percentage of men with an intermediate or good Vertosick score and a higher continence rate after RP in comparison to the non-NS group. Patient summary: Our study shows that after introduction of the NeuroSAFE technique during removal of the prostate, the continence rate among patients was 92% at 1 year and 94% at 2 years after surgery. Some 44% of the men had a good or intermediate score for erectile function 1 and 2 years after surgery.</p

Intraoperative assessment and reporting of radical prostatectomy specimens to guide nerve-sparing surgery in prostate cancer patients (NeuroSAFE)

AIMS: Radical prostatectomy for prostate cancer is frequently complicated by urinary incontinence and erectile dysfunction. Nerve-sparing surgery reduces the risk of post-operative complications and can be optimized using intraoperative frozen sections of the adjacent neurovascular structure (NeuroSAFE). The aim of t

Evaluation of 15 Functional Candidate Genes for Association with Chronic Otitis Media with Effusion and/or Recurrent Otitis Media (COME/ROM)

DNA sequence variants in genes involved in the innate immune response and secondary response to infection may confer susceptibility to chronic otitis media with effusion and/or recurrent otitis media (COME/ROM). We evaluated single nucleotide polymorphisms (SNPs) in 15 functional candidate genes. A total of 99 SNPs were successfully genotyped on the Sequenom platform in 142 families (618 subjects) from the Minnesota COME/ROM Family Study. Data were analyzed for association with COME/ROM using the Generalized Disequilibrium Test (GDT). Sex and age at exam were adjusted as covariates, relatedness was accounted for, and genotype differences from all phenotypically discordant relative pairs were utilized to measure the evidence of association between COME/ROM and each SNP. SNP rs2735733 in the region of the mucin 5, subtypes A/C gene (MUC5AC) exhibited nominal evidence for association with COME/ROM (P = 0.002). Two additional SNPs from this region had P values<0.05. Other variants exhibiting associations with COME/ROM at P<0.05 included the SCN1B SNP rs8100085 (P = 0.013), SFTPD SNP rs1051246 (P = 0.039) and TLR4 SNP rs2770146 (P = 0.038). However, none of these associations replicated in an independent sample of COME/ROM families. The candidate gene variants examined do not appear to make a major contribution to COME/ROM susceptibility, despite a priori evidence from functional or animal model studies for a role in COME/ROM pathology

WATER RIGHTS AND MULTIPLE WATER USES: FRAMEWORK AND APPLICATION TO KIRINDI OYA IRRIGATION SYSTEM, SRI LANKA

The growing attention to water rights in recent years reflects the increasing scarcity and competition for this vital resource. Because rights are at the heart of any water allocation system, they are also critical for any reallocation. Not only efficiency, but also fundamental issues of equity are at stake. But just as water is a fluid and dynamic resource, flowing and seeping in many channels, so also water rights are fluid and dynamic, rarely a single, consistent system. To understand water rights requires going beyond formal statutory law (which may or may not be followed), to look at the many bases for claiming water. Because of the vital nature of this resource, state law, religious law, customary law and local norms all have something to say in defining water rights. The delineation of water rights is further complicated when we take into consideration multiple uses (irrigation, domestic, fishing, livestock, industries, etc.) as well as multiple users (different villages, groups of farmers in the head and tail, fishermen, cattle owners, etc.) of the resource. These overlapping uses bring in different government agencies, as well as different sets of norms and rules related to water. This paper provides a framework for examining the statutory and customary water rights of multiple users of water and applies it in the Kirindi Oya irrigation system in Sri Lanka, based on a multidisciplinary study conducted in 1997-1998. It demonstrates that the range of stakeholders with an interest in water resources of an irrigation system go far beyond the owners and cultivators of irrigated fields. As such, these groups are not only claimants on the ongoing management of water resource systems, but also need to be included in any considerations of transferring water from irrigation to other uses

EPTD DISCUSSION PAPER NO. 59 WATER RIGHTS AND MULTIPLE WATER USES: FRAMEWORK AND APPLICATION TO KIRINDI OYA IRRIGATION SYSTEM, SRI LANKA

The growing attention to water rights in recent years reflects the increasing scarcity and competition for this vital resource. Because rights are at the heart of any water allocation system, they are also critical for any reallocation. Not only efficiency, but also fundamental issues of equity are at stake. But just as water is a fluid and dynamic resource, flowing and seeping in many channels, so also water rights are fluid and dynamic, rarely a single, consistent system. To understand water rights requires going beyond formal statutory law (which may or may not be followed), to look at the many bases for claiming water. Because of the vital nature of this resource, state law, religious law, customary law and local norms all have something to say in defining water rights. The delineation of water rights is further complicated when we take into consideration multiple uses (irrigation, domestic, fishing, livestock, industries, etc.) as well as multiple users (different villages, groups of farmers in the head and tail, fishermen, cattle owners, etc.) of the resource. These overlapping uses bring in different government agencies, as well as different sets of norms and rules related to water. This paper provides a framework for examining the statutory and customary water rights of multiple users of water and applies it in the Kirindi Oya irrigation system in Sri Lanka, based on a multidisciplinary study conducted in 1997-1998. It demonstrates that the range of stakeholders with an interest in water resources of an irrigation system go far beyond the owners and cultivators of irrigated fields. As such, these groups are not only claimants on the ongoing management of water resource systems, but also need to be included in any considerations of transferring water from irrigat..