Socio-Economic Determinants of Household access to Health Services in Selected District of Punjab

Background: Sound health is basic right of every individual and access to health care is necessary. The right to use health services (HS) is a multifarious idea. In Pakistan provision of basic health facilities of health are inadequate. Current study was aimed at highlighting the primary reasons behind it. Methods: This study used cross sectional data from Pakistan Social and Living Standard Measurement (PSLM) to determine the social and economic determinants of health care services in selected districts of province Punjab. Logistic regression technique is used to measure the impact of selected variables on health access. Results:  Results of the study showed that the health access services in the district of Faisalabad are greater as compared to the Rawalpindi and Layyah districts. Moreover, people were using private health facilities as compared to government health facilities. Conclusion: The study indicated that the education level, household (HH) head gender, work status, region and place of residence, and economic situation, affect the health access services in selected regions. Measures should be taken to reduce the monopoly of private health sector by providing better government health facilities

Optimization and validation of high performance liquid chromatography-ultra violet method for quantitation of metoprolol in rabbit plasma: application to pharmacokinetic studies

Purpose: To develop a sensitive, simple and validated high performance liquid chromatography (HPLC) analytical method for the determination of metoprolol tartrate in rabbit plasma.Methods: Mobile phase of methanol and 50 mM ammonium dihydrogen phosphate solution (50:50) at pH 3.05 was used for separation of metoprolol on BDS hypersil C18 column at a wavelength of 223 nm. Flow rate and retention time were 0.6 mL/min and 7.4 min, respectively. For pharmacokinetic study, rabbits were given an oral dose of 8 mg/kg of metoprolol in solution form. Blood samples were taken from jugular vein of the rabbits after drug administration and analysed by HPLC.Results: Separation of metoprolol was not interfered with other components in plasma. The calibration curve was linear in the range of 25 - 1000 ng/mL (r2 = 0.997). Lower limits of detection (LLOD) and quantitation (LLOQ) were 8.87 and 25 ng/mL, respectively. Relative standard deviation (RSD) of intraday and inter-day precision was < 14.27 and 7.61 %, respectively. Relative error of accuracy was between 4.85 and 14.37 %. Maximum plasma concentration (Cmax), time to maximum plasma concentration (Tmax) and half-life (t½) after metoprolol oral administration in rabbits were 186.29 ng/mL, 0.50 h and 2.27 h, respectively.Conclusion: A simple, accurate and precise HPLC-UV method for metoprolol determination in rabbit plasma has been successfully developed and applied to a pharmacokinetic study.Keywords: HPLC-UV, Metoprolol, Pharmacokinetics, Rabbit plasma, Liquid-liquid extraction, Validatio

Frequency of Predisposing Factor of Nausea and Vomiting After Chest Surgery Under General Anaesthesia

Background: Postoperative nausea and vomiting are common and distressing postsurgical symptoms. These symptoms are of particular concern in outpatient surgery because they may require additional direct resources, such as supplies and antiemetic drugs, and may delay discharge. The objective of this study was to measure the frequency of factors which can cause nausea and vomiting under general anaesthesia after chest surgery. Methodology: This descriptive case series evaluated frequency of predisposing factor of nausea and vomiting in patients of anaesthesia department of Gulab Devi Hospital Lahore. Questionnaire is made and patients were asked about their age, fever, previous surgery, NPO status, smoking history and hospital stay. This study included 140 patients with post-operative nausea and vomiting. Results: In this study, 140 patients were taken in which  65 (46.43%) were female and 75 (53.57%) were male. In 140 patient 134 (95.7%) were NPO and 6 (4.3%) were not  NPO, 25 (17.9%) were obese and 115 (82.1%) were not obese, 88 (62.9%) patients were suffering fever and 52 (37.1%) were not suffering fever, 80 (57.1%) were infected and 59 (42.1%) were not infected, 53 (37.9%) patients had previous surgery and 87 (62.1%) had no previous surgery, 94 (67.1%) patients had received nitrous oxide and 46 (32.9%) didn\u27t, 97 (69.3%) received volatile gases and 43 (30.7%) not received, 29 (20.7%) received ketamine and 111 (79.3%) not received, 87 (62.1%) received suxamethonium and 53 (37.9%) not received, 119 (85.0%) received propofol and 21 (15.0%) not received, 110 (78.6%) received naluphine and 28 (20.0%) not received. Out of 140 patients, there were 122 (87.1%) who were suffering from pain and 18 (12.9%) were not. 91 (65.0%) patients had gastric distention and 49 (35.0%) patients didn\u27t. Opioids were given to 34 (24.3%) patients and not given to 106 (75.7%) patient. Conclusion: It is concluded that the nausea and vomiting after surgey under genral anesthesia is due to patient related factors in which most frequent is NPO. Drug related factors include propofol and nalbupin administration. Post operative factors include pain. In whole study of 140 patients, the  most frequent is patient related factor (NPO) other than drug related factors and post-operative factors

Directly printable compact chipless RFID tag for humidity sensing

In this letter, 8-bit paper based printable chipless tag is presented. The tag not only justifies the green electronic concept but also it is examined for sensing functionality. The compact tag structure comprises of seven L-shaped and one I-shaped dipole structure. These conducting tracks/dipole structures are of silver nano-particle based ink having a conductivity of 1.1 × 107 S/m. Each conducting track yields one bit corresponding to one peak. The tag design is optimized and analyzed for three different flexible substrates i.e. paper, Kapton® HN, and PET. The tag has ability to identify 28 = 256 objects, by using different binary combinations. The variation in length of particular conducting strip results in a shift of peak for that specific conducting track. This shift corresponds to logic state-1. The response of the tag for paper, Kapton® HN, and PET substrates is observed in the frequency band of 2.2–6.1 GHz, 2.4–6.3 GHz, and 2.5–6.5 GHz, respectively. The tag has an attractive nature because of its easy printability and usage of low-cost, flexible substrates. The tag can be deployed in various low-cost sensing applications

Abundant explicit solutions to fractional order nonlinear evolution equations

We utilize the modified Riemann-Liouville derivative sense to develop careful arrangements of time-fractional simplified modified Camassa-Holm (MCH) equations and generalized (3 + 1)-dimensional time-fractional Camassa-Holm-Kadomtsev-Petviashvili (gCH-KP) through the potential double G′/G,1/G-expansion method (DEM). The mentioned equations describe the role of dispersion in the formation of patterns in liquid drops ensued in plasma physics, optical fibers, fluid flow, fission and fusion phenomena, acoustics, control theory, viscoelasticity, and so on. A generalized fractional complex transformation is appropriately used to change this equation to an ordinary differential equation; thus, many precise logical arrangements are acquired with all the freer parameters. At the point when these free parameters are taken as specific values, the traveling wave solutions are transformed into solitary wave solutions expressed by the hyperbolic, the trigonometric, and the rational functions. The physical significance of the obtained solutions for the definite values of the associated parameters is analyzed graphically with 2D, 3D, and contour format. Scores of solitary wave solutions are obtained such as kink type, periodic wave, singular kink, dark solitons, bright-dark solitons, and some other solitary wave solutions. It is clear to scrutinize that the suggested scheme is a reliable, competent, and straightforward mathematical tool to discover closed form traveling wave solutions

Fabrication and Evaluation of Rosuvastatin Calcium Fast- Disintegrating Tablets Using β-Cyclodextrin and Superdisintegrants

Purpose: To formulate fast-disintegrating tablets (FDT) of rosuvastatin calcium (RST) using β- cyclodextrin (CD) and different superdisintegrants to enhance their solubility.Methods: A total of 15 FDT formulations of RST were prepared using three different techniques. The FDTs were evaluated for micromeritic properties, as well as by Fourier transform infrared spectroscopy (FTIR), thermal analysis, disintegration time (DT), dissolution rate, powder x-ray diffraction (XRDP), scanning electron microscopy (SEM) and stability studies.Results: XRDP showed that RST was changed from crystalline to amorphous form. SEM images revealed the presence of small microscopic pores that enhanced water penetration and provided rapid dissolution rate compared with the pure drug. There was maximum release of drug (99 %) from F4 formulation containing solid dispersion of RST, CD and superdisintegrants. DT and wetting time were 25 s (p = 0.032) and 33 s (p = 0.023), respectively, for F4 formulation. In vitro dispersion time was also lowest for F4 at 23 s (p = 0.023). FTIR and DSC studies also confirmed complex formation of drug with CD and superdisintegrants.Conclusion: FDT is a suitable strategy to enhance the dissolution rate of RST and thus is an effective tool to improve bioavailability of poorly water soluble drugs.Keywords: Solubility, β-cyclodextrin, Kyron, Polymer, Rosuvastatin, Fast-disintegrating tablet

Anomalous origin of the left coronary artery from the pulmonary artery: A surgical certainty

This study aims to assess the clinical presentation and the outcomes of a surgical correction of an anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA). A retrospective review was carried out on the charts of six patients admitted for ALCAPA surgery at Aga Khan University Hospital, Karachi from March 2017 to May 2018.Dyspnoea, palpitation, poor feeding, fatiguability, pallor and a murmur of mitral regurgitation were the main presenting features. The pre-operative median left ventricular ejection fraction (LVEF) was 64%. Coronary reimplantation was performed in all the patients with a mitral valve repair being done in only one patient. The mea n LV EF was 66 .3%,p ost- ope rativel y. Mitra l regurgitation (MR) improved in patients post-operatively with trace in 2 patients and mild MR in one. Surgical correction by coronary re-implantation yields favourable outcomes in ALCAPA and significantly reduces the morbidity and mortality rates associated with the disease

Machine Learning-Driven Resilient Modulus Prediction for Flexible Pavements Across Mountainous and Other Regions

Accurate estimation of the elastic modulus (Mr) in the com- pacted subgrade soil is essential for the design of flexible pavement systems that are both reliable and environmentally friendly. Mr significantly affects the structural integrity of the pavement, especially in hilly areas with varying loads and climatic conditions. This study collects 2813 data points from pre- vious research results to create an accurate prediction model. The gradient boosted (GB) machine learning (ML) approach is selected to predict the Mr of the compacted subgrade soil. The accuracy and predictive performance of the GB model were evaluated using statistical analysis that includes fun- damental metrics such as root mean square error, mean absolute error, and relative squared error. The model obtained R² values of 0.96 and 0.94 for the training and testing datasets. The RMSE was 5 MPa for training and 7.48 MPa for testing, while the MAE was 3.18 MPa and 5.55 MPa. These results highlight the potential of GB in predicting soil Mr, thereby supporting the development of more accurate and efficient Mr prediction, ultimately reduc- ing time and cost

An analytical approach to the solution of fractional-coupled modified equal width and fractional - coupled Burgers equations

We opted to construct a traveling wave solution to the nonlinear space-time fractional coupled modified equal width (CMEW) equation and the space-time fractional-coupled Burgers equation, which are often used as an electro-hydro-dynamical model to advance the local electric field and particle acoustic waves in plasma, the shallow water wave issues and portray the variety additional time of an actual structure on the partial liquid mechanics framework, particle acoustic waves through a gas-filled line, and certain consistent state gooey liquid. In this study, we employ the two variable (G /G, 1/G)-expansion method to create further general solitary wave solutions to those equations based on Riemann– Liouville fractional derivative. The fractional differential wave transform simplifies by generating ordinary differential equations (ODE) from fractional-order differential equations. We identified multiple types of solutions through the maple that are illustrated using 3D shape, 3D list point plot, and contour narratives. Additionally, we proposed that the methodology be changed to be more pragmatic, economical, and dependable and that we investigate more generalized precise solutions for traveling waves, such as solitary wave solutions