Dose of colistin. a work in progress?

We thank Rashid and colleagues [1] and Honoré and colleagues [2] for their comments regarding our article on risk factors for acute kidney injury in pa- tients receiving colistin or other nephrotoxic antimi- crobials [3]. It is correct that we did not specifically report urine output in the text, but it was obviously included in the RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease) criteria reported in Table two [3]

Host genetics: deciphering the variability in susceptibility to infections

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Immunodeficiency-associated viral oncogenesis

AbstractSeveral viruses with different replication mechanisms contribute to oncogenesis by both direct and indirect mechanisms in immunosuppressed subjects after solid organ transplantation, after allogeneic stem cell transplantation, or with human immunodeficiency virus (HIV) infection. Epstein–Barr virus (EBV), human papillomavirus (HPV), Kaposi sarcoma herpesvirus (KSHV), human T-cell lymphotropic virus type 1 (HTLV-1) and Merkel cell polyoma virus (MCV) are the main viruses associated with the development of cancer in immunosuppressed patients. Besides being a main cause of immunodeficiency, HIV1 has a direct pro-oncogenic effect. In this review, we provide an update on the association between the condition of acquired immunodeficiency and cancer risk, specifically addressing the contributions to oncogenesis of HPV, MCV, KSHV, HTLV-1, and EBV

Integration of the viral genome into the host cell genome: a double-edged sword

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Extinction properties of the X-ray bright/optically faint afterglow of GRB 020405

We present an optical-to-X-ray spectral analysis of the afterglow of GRB 020405. The optical spectral energy distribution not corrected for the extragalactic extinction is significantly below the X-ray extrapolation of the single powerlaw spectral model suggested by multiwavelength studies. We investigate whether considerable extinction could explain the observed spectral ``mismatch'' by testing several types of extinction curves. For the first time we test extinction curves computed with time-dependent numerical simulations of dust grains destruction by the burst radiation. We find that an extinction law weakly depen dent on wavelength can reconcile the unabsorbed optical and X-ray data with the expected synchrotron spectrum. A gray extinction law can be provided by a dust grain size distribution biased toward large grains.Comment: 6 pages, 5 figures, accepted for publication on A&

Automotive Stirling Engine Development Program

Mod I engine testing and test results, the test of a Mod I engine in the United States, Mod I engine characterization and analysis, Mod I Transient Test Bed fuel economy, Mod I-A engine performance are discussed. Stirling engine reference engine manufacturing and reduced size studies, components and subsystems, and the study and test of low-cost casting alloys are also covered. The overall program philosophy is outlined, and data and results are presented