Aminative Umpolung Synthesis of Aryl Vicinal Diamines from Aromatic Aldehydes

In this paper an aminative umpolung synthesis of aryl vicinal diamines from aldehydes and <i>N</i>-Ts imines is described. Electrophilic aromatic aldehydes were smoothly converted into delocalized 2-azaallylanions via condensation with 2,2-diphenylglycine in methanol and subsequent decarboxylation in THF and underwent further reaction with <i>N</i>-Ts imines to give a variety of 1,2-diamine derivatives in good yields with high <i>syn</i>/<i>anti</i> diastereoselectivity

Stretchable Fibers with Highly Conductive Surfaces and Robust Electromechanical Performances for Electronic Textiles

One-dimensional conductive fibers that can simultaneously accommodate multiple deformations are crucial materials to enable next-generation electronic textile technologies for applications in the fields of healthcare, energy harvesting, human-machine interactions, etc. Stretchable conductive fibers (SCFs) with high conductivity on their external structure are important for their direct integration with other electronic components. However, the dilemma to achieve high conductivity and concurrently large stretchability is still quite challenging to resolve among conductive fibers with a conductive surface. Here, a three-layer coaxial conductive fiber, which can provide robust electrical performance under various deformations, is reported. A dual conducting structure with a semisolid metallic layer and a stretchable composite layer was designed in the fibers, providing exceptional conductivity and mechanical stability under mechanical strains. The conductive fiber achieved an initial conductivity of 2291.83 S cm–1 on the entire fiber and could be stretched up to 600% strains. With the excellent electromechanical properties of the SCF, we were able to demonstrate different electronic textile applications including physiological monitoring, neuromuscular electrical stimulation, and energy harvesting

Aminative Umpolung Synthesis of Aryl Vicinal Diamines from Aromatic Aldehydes

In this paper an aminative umpolung synthesis of aryl vicinal diamines from aldehydes and <i>N</i>-Ts imines is described. Electrophilic aromatic aldehydes were smoothly converted into delocalized 2-azaallylanions via condensation with 2,2-diphenylglycine in methanol and subsequent decarboxylation in THF and underwent further reaction with <i>N</i>-Ts imines to give a variety of 1,2-diamine derivatives in good yields with high <i>syn</i>/<i>anti</i> diastereoselectivity

Stretchable Fibers with Highly Conductive Surfaces and Robust Electromechanical Performances for Electronic Textiles

One-dimensional conductive fibers that can simultaneously accommodate multiple deformations are crucial materials to enable next-generation electronic textile technologies for applications in the fields of healthcare, energy harvesting, human-machine interactions, etc. Stretchable conductive fibers (SCFs) with high conductivity on their external structure are important for their direct integration with other electronic components. However, the dilemma to achieve high conductivity and concurrently large stretchability is still quite challenging to resolve among conductive fibers with a conductive surface. Here, a three-layer coaxial conductive fiber, which can provide robust electrical performance under various deformations, is reported. A dual conducting structure with a semisolid metallic layer and a stretchable composite layer was designed in the fibers, providing exceptional conductivity and mechanical stability under mechanical strains. The conductive fiber achieved an initial conductivity of 2291.83 S cm–1 on the entire fiber and could be stretched up to 600% strains. With the excellent electromechanical properties of the SCF, we were able to demonstrate different electronic textile applications including physiological monitoring, neuromuscular electrical stimulation, and energy harvesting

Stretchable Fibers with Highly Conductive Surfaces and Robust Electromechanical Performances for Electronic Textiles

One-dimensional conductive fibers that can simultaneously accommodate multiple deformations are crucial materials to enable next-generation electronic textile technologies for applications in the fields of healthcare, energy harvesting, human-machine interactions, etc. Stretchable conductive fibers (SCFs) with high conductivity on their external structure are important for their direct integration with other electronic components. However, the dilemma to achieve high conductivity and concurrently large stretchability is still quite challenging to resolve among conductive fibers with a conductive surface. Here, a three-layer coaxial conductive fiber, which can provide robust electrical performance under various deformations, is reported. A dual conducting structure with a semisolid metallic layer and a stretchable composite layer was designed in the fibers, providing exceptional conductivity and mechanical stability under mechanical strains. The conductive fiber achieved an initial conductivity of 2291.83 S cm–1 on the entire fiber and could be stretched up to 600% strains. With the excellent electromechanical properties of the SCF, we were able to demonstrate different electronic textile applications including physiological monitoring, neuromuscular electrical stimulation, and energy harvesting

Aminative Umpolung Synthesis of Aryl Vicinal Diamines from Aromatic Aldehydes

In this paper an aminative umpolung synthesis of aryl vicinal diamines from aldehydes and <i>N</i>-Ts imines is described. Electrophilic aromatic aldehydes were smoothly converted into delocalized 2-azaallylanions via condensation with 2,2-diphenylglycine in methanol and subsequent decarboxylation in THF and underwent further reaction with <i>N</i>-Ts imines to give a variety of 1,2-diamine derivatives in good yields with high <i>syn</i>/<i>anti</i> diastereoselectivity

Stretchable Fibers with Highly Conductive Surfaces and Robust Electromechanical Performances for Electronic Textiles

One-dimensional conductive fibers that can simultaneously accommodate multiple deformations are crucial materials to enable next-generation electronic textile technologies for applications in the fields of healthcare, energy harvesting, human-machine interactions, etc. Stretchable conductive fibers (SCFs) with high conductivity on their external structure are important for their direct integration with other electronic components. However, the dilemma to achieve high conductivity and concurrently large stretchability is still quite challenging to resolve among conductive fibers with a conductive surface. Here, a three-layer coaxial conductive fiber, which can provide robust electrical performance under various deformations, is reported. A dual conducting structure with a semisolid metallic layer and a stretchable composite layer was designed in the fibers, providing exceptional conductivity and mechanical stability under mechanical strains. The conductive fiber achieved an initial conductivity of 2291.83 S cm–1 on the entire fiber and could be stretched up to 600% strains. With the excellent electromechanical properties of the SCF, we were able to demonstrate different electronic textile applications including physiological monitoring, neuromuscular electrical stimulation, and energy harvesting

Table_1_Celastrol Inhibits Canine Mammary Tumor Cells by Inducing Apoptosis via the Caspase Pathway.XLSX

Canine mammary tumor is a serious disease threatening the health of dogs and can be used as a research model for human breast cancer. The study of canine mammary tumor has a role in improving the welfare of dogs. Most common canine mammary tumor chemotherapy drugs have limited effects and drug resistance. Celastrol is an extract of Tripterygium wilfordii, which has a wide range of biological activities, including significant anti-tumor effects. At present, celastrol has not been used in the clinical treatment for canine mammary tumor. This study investigated the anti-tumor properties of celastrol through in vitro assay of cell proliferation inhibition, cell colony, cell migration, and invasion; flow cytometry, qPCR, and Western Blot methods were used to explore the anti-tumor mechanism of celastrol. The results showed that celastrol can inhibit the proliferation of canine mammary tumor cells in vitro, and decrease the migration and invasion ability of canine mammary tumor cells. We also found that celastrol can upregulate Cleaved Caspase-3 and Cleaved Caspase-9 protein expression levels to promote cell apoptosis, and can regulate cell cycle-related proteins to induce cell cycle arrest. In summary, celastrol may inhibit canine mammary tumor cells through the Caspase pathway, providing a new direction for anti-canine mammary tumor drugs, and is expected to become a new anti-cancer drug for canine mammary tumors.</p

Stretchable Fibers with Highly Conductive Surfaces and Robust Electromechanical Performances for Electronic Textiles

One-dimensional conductive fibers that can simultaneously accommodate multiple deformations are crucial materials to enable next-generation electronic textile technologies for applications in the fields of healthcare, energy harvesting, human-machine interactions, etc. Stretchable conductive fibers (SCFs) with high conductivity on their external structure are important for their direct integration with other electronic components. However, the dilemma to achieve high conductivity and concurrently large stretchability is still quite challenging to resolve among conductive fibers with a conductive surface. Here, a three-layer coaxial conductive fiber, which can provide robust electrical performance under various deformations, is reported. A dual conducting structure with a semisolid metallic layer and a stretchable composite layer was designed in the fibers, providing exceptional conductivity and mechanical stability under mechanical strains. The conductive fiber achieved an initial conductivity of 2291.83 S cm–1 on the entire fiber and could be stretched up to 600% strains. With the excellent electromechanical properties of the SCF, we were able to demonstrate different electronic textile applications including physiological monitoring, neuromuscular electrical stimulation, and energy harvesting

Stretchable Fibers with Highly Conductive Surfaces and Robust Electromechanical Performances for Electronic Textiles

One-dimensional conductive fibers that can simultaneously accommodate multiple deformations are crucial materials to enable next-generation electronic textile technologies for applications in the fields of healthcare, energy harvesting, human-machine interactions, etc. Stretchable conductive fibers (SCFs) with high conductivity on their external structure are important for their direct integration with other electronic components. However, the dilemma to achieve high conductivity and concurrently large stretchability is still quite challenging to resolve among conductive fibers with a conductive surface. Here, a three-layer coaxial conductive fiber, which can provide robust electrical performance under various deformations, is reported. A dual conducting structure with a semisolid metallic layer and a stretchable composite layer was designed in the fibers, providing exceptional conductivity and mechanical stability under mechanical strains. The conductive fiber achieved an initial conductivity of 2291.83 S cm–1 on the entire fiber and could be stretched up to 600% strains. With the excellent electromechanical properties of the SCF, we were able to demonstrate different electronic textile applications including physiological monitoring, neuromuscular electrical stimulation, and energy harvesting