Additional file 1: Figure S1. of Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei

Correspondence between Dbx1-driven recombination and Dbx1 expression. Regions of recombination in the tuberal hypothalamus (schematic on left) at the level of the E11.5 lateral hypothalamic primordium and (A-C) and E12.5 arcuate nucleus primordium (E-G) are shown. Filled arrowheads highlight recombined Dbx1-derived YFP+ cells (A, C, E, G). Open arrowheads highlight Dbx1+ progenitors (B, F, C, G). A small number of YFP+/Dbx1+ double-labeled cells are observed (boxed area in G and high magnification shown on right panels). The low number of double-labeled cells is likely due to the time lag between the transient expression of Dbx1 in dividing progenitors and YFP expression resulting from Cre-driven recombination. Abbreviation: 3rd V (3rd ventricle). (TIF 44748 kb

Additional file 3: Figure S3. of Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei

Increased c-Fos in Arc, LH, and VMH after innate behaviors. (A-D.i) Images of the c-Fos expression in the Arc (A-D), LH (E-H), and VMH (I-L) after mice were exposed to mating (A, E, and I), aggression (B, F, and J), fasting (C, G, and K), or predator (D, H, and L) behavioral paradigms. The number of cells expressing c-Fos in the Arc, LH, and VMH are increased after exposure to the four behavioral paradigms. The scale bar represents 500 μm in the LH and VMH (A-D.i, I-L.i) and 250 μm in the Arc (E-H.i). (TIF 172032 kb

Additional file 2: Figure S2. of Molecular and behavioral profiling of Dbx1-derived neurons in the arcuate, lateral and ventromedial hypothalamic nuclei

Dbx1-derived cells in nuclei as defined by specific markers. (A-D) Schematic of medial (top) to lateral (bottom) sagittal views of the embryonic forebrain. (A.i-D.i) As shown by YFP expression in E13.5 Dbx1 Cre ;Rosa26YFP embryos, Dbx1-derived cells are are found in primordial hypothalamic nuclei including in the paraventricular, arcuate, ventral medial and lateral progenitor domains. (A.ii-D.iii) As shown by ISH of serial sections, specific markers of the paraventriclar (Sim1, A.ii; Fezf1, A.iii), arcuate (Pomc, B.ii; Bsx, B.iii), ventral medial (Fezf1, C.ii; Nr5a1, C.iii) and lateral hypothalamic (Pmch, D.ii; Lhx9, D.iii) nuclei overlap with expression of YFP. The scale bar represents 500 μm. (TIF 157696 kb

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