Supplementary Table 1 from Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

XLSX file - 79KB, Genes regulated by pentamidine in 786-O cells after 6h incubation.</p

Supplementary Figure 8 from Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

PDF file - 953KB, Heatmap of top up- and down-regulated genes in response to pentamidine 25 microM treatment of 786-O cells for 6 hrs.</p

Supplementary Figure 6 from Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

PDF file - 1103KB, Apoptosis assay for (A) VHL (-) and (B) VHL (+) 786-O RCC cells treated with pentamidine 100, 50, 20 and 10 microM, olygomycin 1, 0.5, 0.2 and 0.1 microM, oxaprozin 300, 150, 60 and 30 microM and dopamine 1, 0.5, 0.2 and 0.1 microM for 24 hours.</p

Supplementary Figure 7 from Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

PDF file - 446KB, Apoptosis assay for RCC4 VHL (-) RCC4 VHL (+) cell lines.</p

Supplementary Figure 3 from Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

PDF file - 230KB, Evaluation of apoptosis in non-RCC cells treated with high scoring candidate drugs from the Connectivity Map.</p

Supplementary Figure 5 from Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

PDF file - 281KB, Apoptosis assay for RCC4 VHL (-) and VHL (+) cells treated with pentamidine 100 microM, olygomycin 1 microM, oxaprozin 300 microM and dopamine 1 microM.</p

Supplementary Figure 1 from Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

PDF file - 202KB, Flowchart of study design.</p

Supplementary Methods from Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

PDF file - 93KB</p

Supplementary Figure Legends from Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

PDF file - 76KB</p

Supplementary Figure 4 from Computational Repositioning and Preclinical Validation of Pentamidine for Renal Cell Cancer

PDF file - 1679KB, Apoptosis assay for (A) UOK and (B) ACHN RCC cells treated with amitriptyline 0.025 and 0.05 microM, pentamidine 20 microM, olygomycin 0.2 microM, oxaprozin 150 microM, dopamine 0.2 microM and combinations of each 2 or 3 drugs in the same concentrations for 24 hours.</p