Long-term impact of the low-FODMAP diet on gastrointestinal symptoms, dietary intake, patient acceptability, and healthcare utilization in irritable bowel syndrome

Background: The low-FODMAP diet is a frequently used treatment for irritable bowel syndrome (IBS). Most research has focused on short-term FODMAP restriction; however, guidelines recommend that high-FODMAP foods are reintroduced to individual tolerance. This study aimed to assess the long-term effectiveness of the low-FODMAP diet following FODMAP reintroduction in IBS patients. Methods: Patients with IBS were prospectively recruited to a questionnaire study following completion of dietitian-led low-FODMAP education. At baseline and following FODMAP restriction (short term) only, gastrointestinal symptoms were measured as part of routine clinical care. Following FODMAP reintroduction, (long term), symptoms, dietary intake, acceptability, food-related quality of life (QOL), and healthcare utilization were assessed. Data were reported for patients who continued long-term FODMAP restriction (adapted FODMAP) and/or returned to a habitual diet (habitual). Key Results: Of 103 patients, satisfactory relief of symptoms was reported in 12% at baseline, 61% at short-term follow-up, and 57% at long-term follow-up. At long-term follow-up, 84 (82%) patients continued an ‘adapted FODMAP’ diet (total FODMAP intake mean 20.6, SD 14.9\ua0g/d) compared with 19 (18%) of patients following a ‘habitual’ diet (29.4, SD 22.9\ua0g/d, P=.039). Nutritional adequacy was not compromised for either group. The ‘adapted FODMAP’ group reported the diet cost significantly more than the ‘habitual’ group (

Common <i>CYP2B6</i> splice-forms, and the relative locations of primers used in quantitative real-time splice-form expression assays.

<p>Splice form nomenclature follows prior literature <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079700#pone.0079700-Hofmann1" target="_blank">[27]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079700#pone.0079700-Lamba1" target="_blank">[28]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0079700#pone.0079700-Miles1" target="_blank">[38]</a>. The locations of common non-synonymous variants are marked on the full-length transcript. Not to scale.</p

Saxifraga cherlerioides D. Don var. rebunshirensis Hara

原著和名: シコタンサウ科名: ユキノシタ科 = Saxifragaceae採集地: 長野県 八ヶ岳麓 (信濃 八ヶ岳麓)採集日: 1953/7/12採集者: 萩庭丈壽整理番号: JH046163国立科学博物館整理番号: TNS-VS-99616

Additional file 3: of Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

File contains a Q-Q plot of the plasma data used in this study. (DOCX 74 kb

Additional file 2: of Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels

File contains the forge_metal.py program, which is used to run METAL on the samples form each dataset to combine data. (DOCX 85 kb

Additional file 4: of Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

File contains a Q-Q plot of the CSF data used in this study. (DOCX 76 kb

LD structure of the <i>CYP2A6/CYP2B6</i> locus for common SNPs genotyped in the COGEND metabolism study.

<p>Numbers refer to pairwise R².</p

Additional file 9: of Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels

File contains a Q-Q plot of the CSF in the ADNI samples. (DOCX 54 kb

Additional file 2: of Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid

File contains a table of SNPs significantly associated with prolactin levels in CSF by meta-analysis. (DOCX 183 kb

<i>CYP2B6</i> haplotypes associated with D₂cotinine/(D₂cotinine+ D₂nicotine) in a multivariate regression model with <i>CYP2A6</i> haplotypes.

a<p>the probability that the parameter estimate is different by chance from the reference, i.e. all <i>CYP2A6</i> (n = 271) and <i>CYP2B6</i> (n = 126) alleles not included in the multivariate regression. All <i>CYP2A6</i> alleles presented are loss-of-function alleles associated with reduced metabolism (−) relative to the reference <i>CYP2A6</i> alleles; all <i>CYP2B6</i> alleles presented are associated with increased metabolism (+) relative to the reference (rs8109525G) <i>CYP2B6</i> alleles. rs8109525 is in high linkage disequilibrium with rs8100458 (R²>0.95).</p