Baseline, 6 and 12 week means and mean differences of memantine versus placebo using last outcome carried forward adjusted for baseline (except CGI as no baseline).

<p>The effect at weeks 6 & 12 uses lme and adjusts for baseline for CMAI, NPI, SIB and SMMSE.* p<0.05 ** p <0.01 *** P<0.001. NPI =  Neuropsychiatric Inventory; CGIC = Clinical Global Impression of change; SMMSE =  Standard Mini Mental State examination; CMAI =  Cohen Mansfield Agitation Index; SIB =  Severe Impairment Battery.</p

Baseline demographic and clinical values at randomisation according to study group.

<p>Baseline demographic and clinical values at randomisation according to study group.</p

CONSORT STATEMENT.

<p>CONSORT STATEMENT.</p

Adverse events.

<p>Adverse events.</p

Mean (+/−95% Confidence intervals) total NPI by time and by group.

<p>Mean (+/−95% Confidence intervals) total NPI by time and by group.</p

Mean (+/−95% confidence intervals) total CMAI by time and by group.

<p>Circles are individual data points; red: memantine, blue: placebo.</p