On concepts and methods in horizon scanning: Lessons from initiating policy dialogues on emerging issues

Future-oriented technology analysis methods can play a significant role in enabling early warning signal detection and pro-active policy action which will help to better prepare policy- and decision-makers in today's complex and inter-dependent environments. This paper analyses the use of different horizon scanning approaches and methods as applied in the Scanning for Emerging Science and Technology Issues project. A comparative analysis is provided as well as a brief evaluation the needs of policy-makers if they are to identify areas in which policy needs to be formulated. This paper suggests that the selection of the best scanning approaches and methods is subject to contextual and content issues. At the same time, there are certain issues which characterise horizon scanning processes, methods and results that should be kept in mind by both practitioners and policy-maker

On concepts and methods in horizon scanning : lessons from initiating policy dialogues on emerging issues

Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)Future-oriented technology analysis methods can play a significant role in enabling early warning signal detection and pro-active policy action which will help to better prepare policy- and decision-makers in today’s complex and inter-dependent environments. This paper analyses the use of different horizon scanning approaches and methods as applied in the Scanning for Emerging Science and Technology Issues project. A comparative analysis is provided as well as a brief evaluation the needs of policy-makers if they are to identify areas in which policy needs to be formulated. This paper suggests that the selection of the best scanning approaches and methods is subject to contextual and content issues. At the same time, there are certain issues which characterise horizon scanning processes, methods and results that should be kept in mind by both practitioners and policy-makers

SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human-induced pluripotent stem-cell-derived kidney organoids with SARS-CoV-2. Single-cell RNA sequencing indicated injury and dedifferentiation of infected cells with activation of profibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in long COVID

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

We report the results of the COVID Moonshot, a fully open-science, crowdsourced, and structure-enabled drug discovery campaign targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease. We discovered a noncovalent, nonpeptidic inhibitor scaffold with lead-like properties that is differentiated from current main protease inhibitors. Our approach leveraged crowdsourcing, machine learning, exascale molecular simulations, and high-throughput structural biology and chemistry. We generated a detailed map of the structural plasticity of the SARS-CoV-2 main protease, extensive structure-activity relationships for multiple chemotypes, and a wealth of biochemical activity data. All compound designs (>18,000 designs), crystallographic data (>490 ligand-bound x-ray structures), assay data (>10,000 measurements), and synthesized molecules (>2400 compounds) for this campaign were shared rapidly and openly, creating a rich, open, and intellectual property–free knowledge base for future anticoronavirus drug discovery

Triage of patients with venous and lymphatic diseases during the COVID-19 pandemic – The Venous and Lymphatic Triage and Acuity Scale (VELTAS):: A consensus document of the International Union of Phlebology (UIP), Australasian College of Phlebology (ACP), American Vein and Lymphatic Society (AVLS), American Venous Forum (AVF), European College of Phlebology (ECoP), European Venous Forum (EVF), Interventional Radiology Society of Australasia (IRSA), Latin American Venous Forum, Pan-American Society of Phlebology and Lymphology and the Venous Association of India (VAI)

The coronavirus disease 2019 (COVID-19) global pandemic has resulted in diversion of healthcare resources to the management of patients infected with SARS-CoV-2 virus. Elective interventions and surgical procedures in most countries have been postponed and operating room resources have been diverted to manage the pandemic. The Venous and Lymphatic Triage and Acuity Scale was developed to provide an international standard to rationalise and harmonise the management of patients with venous and lymphatic disorders or vascular anomalies. Triage urgency was determined based on clinical assessment of urgency with which a patient would require medical treatment or surgical intervention. Clinical conditions were classified into six categories of: (1) venous thromboembolism (VTE), (2) chronic venous disease, (3) vascular anomalies, (4) venous trauma, (5) venous compression and (6) lymphatic disease. Triage urgency was categorised into four groups and individual conditions were allocated to each class of triage. These included (1) medical emergencies (requiring immediate attendance), example massive pulmonary embolism; (2) urgent (to be seen as soon as possible), example deep vein thrombosis; (3) semiurgent (to be attended to within 30-90 days), example highly symptomatic chronic venous disease, and (4) discretionary/nonurgent- (to be seen within 6-12 months), example chronic lymphoedema. Venous and Lymphatic Triage and Acuity Scale aims to standardise the triage of patients with venous and lymphatic disease or vascular anomalies by providing an international consensus-based classification of clinical categories and triage urgency. The scale may be used during pandemics such as the current COVID-19 crisis but may also be used as a general framework to classify urgency of the listed conditions

On concepts and methods in horizon scanning: lessons from initiating policy dialogues on emerging issues

Future-oriented technology analysis methods can play a significant role in enabling early warning signal detection and pro-active policy action which will help to better prepare policy- and decision-makers in today's complex and inter-dependent environments. This paper analyses the use of different horizon scanning approaches and methods as applied in the Scanning for Emerging Science and Technology Issues project. A comparative analysis is provided as well as a brief evaluation the needs of policy-makers if they are to identify areas in which policy needs to be formulated. This paper suggests that the selection of the best scanning approaches and methods is subject to contextual and content issues. At the same time, there are certain issues which characterise horizon scanning processes, methods and results that should be kept in mind by both practitioners and policy-maker