Low-dimensional chaos in populations of strongly-coupled noisy maps

We characterize the macroscopic attractor of infinite populations of noisy maps subjected to global and strong coupling by using an expansion in order parameters. We show that for any noise amplitude there exists a large region of strong coupling where the macroscopic dynamics exhibits low-dimensional chaos embedded in a hierarchically-organized, folded, infinite-dimensional set. Both this structure and the dynamics occuring on it are well-captured by our expansion. In particular, even low-degree approximations allow to calculate efficiently the first macroscopic Lyapunov exponents of the full system.Comment: 16 pages, 9 figures. Progress of Theoretical Physics, to appea

Noise-induced macroscopic bifurcations in globally-coupled chaotic units

Large populations of globally-coupled identical maps subjected to independent additive noise are shown to undergo qualitative changes as the features of the stochastic process are varied. We show that for strong coupling, the collective dynamics can be described in terms of a few effective macroscopic degrees of freedom, whose deterministic equations of motion are systematically derived through an order parameter expansion.Comment: Phys. Rev. Lett., accepte

Evolving social behavior through selection of single-cell adhesion in Dictyostelium discoideum

The social amoeba Dictyostelium discoideum commonly forms chimeric fruiting bodies. Genetic variants that produce a higher proportion of spores are predicted to undercut multicellular organization unless cooperators assort positively. Cell adhesion is considered a primary factor driving such assortment, but evolution of adhesion has not been experimentally connected to changes in social performance. We modified by experimental evolution the efficiency of individual cells in attaching to a surface. Surprisingly, evolution appears to have produced social cooperators irrespective of whether stronger or weaker adhesion was selected. Quantification of reproductive success, cell-cell adhesion, and developmental patterns, however, revealed two distinct social behaviors, as captured when the classical metric for social success is generalized by considering clonal spore production. Our work shows that cell mechanical interactions can constrain the evolution of development and sociality in chimeras and that elucidation of proximate mechanisms is necessary to understand the ultimate emergence of multicellular organization

The Kuramoto model with distributed shear

We uncover a solvable generalization of the Kuramoto model in which shears (or nonisochronicities) and natural frequencies are distributed and statistically dependent. We show that the strength and sign of this dependence greatly alter synchronization and yield qualitatively different phase diagrams. The Ott-Antonsen ansatz allows us to obtain analytical results for a specific family of joint distributions. We also derive, using linear stability analysis, general formulae for the stability border of incoherence.Comment: 6 page

Platelet-rich gel for the adjuvant treatment of wound healing of transposed flap for arteriovenous fistula in systemic scleroderma

LETTER TO EDITO

Oscillations in Optional Public Good Games

We present a new mechanism promoting cooperative behavior among selfish individuals in the public goods game. This game represents a straightforward generalization of the prisoner's dilemma to an arbitrary number of players. In contrast to the compulsory public goods game, optional participation provides a natural way to avoid deadlocks in the state of mutual defection. The three resulting strategies - collaboration or defection in the public goods game, as well as not joining at all -are studied by means of a replicator dynamics, which can be completely analysed in spite of the fact that some payoff terms are nonlinear. If cooperation is valuable enough, the dynamics exhibits a rock-scissors-paper type of cycling between the three strategies, leading to sizeable average levels of cooperation in the population. Thus, voluntary participation makes cooperation possible. But for each strategy, the average payoff value remains equal to the earnings of those not participating in the public goods game

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives

Aggregative cycles evolve as a solution to conflicts in social investment

Multicellular organization is particularly vulnerable to conflicts between different cell types when the body forms from initially isolated cells, as in aggregative multicellular microbes. Like other functions of the multicellular phase, coordinated collective movement can be undermined by conflicts between cells that spend energy in fuelling motion and ‘cheaters’ that get carried along. The evolutionary stability of collective behaviours against such conflicts is typically addressed in populations that undergo extrinsically imposed phases of aggregation and dispersal. Here, via a shift in perspective, we propose that aggregative multicellular cycles may have emerged as a way to temporally compartmentalize social conflicts. Through an eco-evolutionary mathematical model that accounts for individual and collective strategies of resource acquisition, we address regimes where different motility types coexist. Particularly interesting is the oscillatory regime that, similarly to life cycles of aggregative multicellular organisms, alternates on the timescale of several cell generations phases of prevalent solitary living and starvation-triggered aggregation. Crucially, such self-organized oscillations emerge as a result of evolution of cell traits associated to conflict escalation within multicellular aggregates