Data_Sheet_1_The Effect of Conservative Oxygen Therapy in Reducing Mortality in Critical Care Patients: A Meta-Analysis and Trial Sequential Analysis.PDF

Background: Conservative oxygen therapy can prevent both hypoxemia and hyperoxemia, but the effect on the prognosis of patients admitted to the intensive care unit (ICU) remains controversial.Methods: All controlled studies comparing conservative oxygen therapy and conventional oxygen therapy in adult patients admitted to the ICU were searched. The primary outcome was mortality, and the secondary outcomes were length of ICU stay (ICU LOS), length of hospital stay (hospital LOS), length of mechanical ventilation (MV) hours, new organ failure during ICU stay, and new infections during ICU stay.Results: Nine trials with a total of 5,759 patients were pooled in our final studies. Compared with conventional oxygen therapy, conservative oxygen therapy did not reduce overall mortality (Z = 0.31, p = 0.75) or ICU LOS (Z = 0.17, p = 0.86), with firm evidence from trial sequential analysis, or hospital LOS (Z = 1.98, p = 0.05) or new infections during the ICU stay (Z = 1.45, p = 0.15). However, conservative oxygen therapy was associated with a shorter MV time (Z = 5.05, p Conclusion: Conservative oxygen therapy did not reduce mortality but did decrease MV time, new organ failure and risk of RRT in critically ill patients.Systematic Review Registration: identifier [CRD42020171055].</p

Additional file 4: of The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Figure S3. Mortality of patients with traumatic brain injury. OR, odds ratio; CI, confidence interval. (PNG 9 kb

Additional file 3: of The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Figure S2. Mortality of patients with cardiac arrest. OR, odds ratio; CI, confidence interval. (PNG 9 kb

Additional file 5: of The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Figure S4. Mortality of patients with stroke hemorrhage. OR, odds ratio; CI, confidence interval. (PNG 8 kb

Additional file 1: of The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Assessment of risk of bias and study quality. (DOC 18 kb

Additional file 6: of The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Figure S5. Mortality of patients with post cardiac surgery. OR, odds ratio; CI, confidence interval. (PNG 7 kb

Additional file 2: of The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Figure S1. Mortality of patients with mechanical ventilation. OR, odds ratio; CI, confidence interval. (PNG 8 kb

Additional file 7: of The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Figure S6. Mortality of patients with ELS. ELS, extracorporeal life support; OR, odds ratio; CI, confidence interval. (PNG 8 kb

Additional file 2: of The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis

Subgroup analysis according to virus type. (DOCX 88 kb

Additional file 1: of The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis

Assessment of risk of bias and study quality. (DOCX 15 kb