Development of Binaphthyl-Based Chiral Dienes for Rhodium(I)-Catalyzed Asymmetric Arylation of <i>N</i>,<i>N</i>-Dimethylsulfamoyl-Protected Aldimines

A variety of binaphthyl-based chiral dienes were synthesized and utilized as steering ligands for the enantioselective arylation of N,N-dimethylsulfamoyl-protected aldimines with arylboronic acids, and moderate to good yields and up to 84% ee were achieved

Asymmetric Allylic Alkylation of Pyrroles and 4,7-Dihydroindoles with Alkene–Phosphine Ligands

A palladium-catalyzed highly enantioselective allylic alkylation of pyrroles and 4,7-dihydroindoles has been successfully developed with the use of chiral alkene-phosphine hybrid ligands to furnish the desired products in high yields with excellent ee’s. It is noteworthy that alkene–phosphine ligands are much more effective than some other types of chiral ligands in this catalytic system

Asymmetric Allylic Alkylation of Pyrroles and 4,7-Dihydroindoles with Alkene–Phosphine Ligands

A palladium-catalyzed highly enantioselective allylic alkylation of pyrroles and 4,7-dihydroindoles has been successfully developed with the use of chiral alkene-phosphine hybrid ligands to furnish the desired products in high yields with excellent ee’s. It is noteworthy that alkene–phosphine ligands are much more effective than some other types of chiral ligands in this catalytic system

Pd-Catalyzed Asymmetric Allylic Etherizations with Oximes by Chiral Alkene-Phosphine Ligands

Palladium-catalyzed asymmetric allylic etherizations with a variety of oximes as nucleophiles utilizing a chiral alkene-phosphine hybrid ligand have been successfully achieved for the first time to afford the optical active oxime ethers in high yields with good to excellent enantioselectivities

Simple Chiral Chain Dienes as Ligands for Rh(I)-Catalyzed Conjugated Additions

This paper describes that a simple and readily available chain diene (3R,4R)-hexa-1,5-diene-3,4-diol (L1) was successfully utilized as a novel steering ligand for Rh(I)-catalyzed asymmetric conjugated additions. Encouraging yields and ee’s have been achieved, which may provide a new and practical direction for designing chiral diene ligands in the future

Pd-Catalyzed Asymmetric Allylic Etherizations with Oximes by Chiral Alkene-Phosphine Ligands

Palladium-catalyzed asymmetric allylic etherizations with a variety of oximes as nucleophiles utilizing a chiral alkene-phosphine hybrid ligand have been successfully achieved for the first time to afford the optical active oxime ethers in high yields with good to excellent enantioselectivities

Pd-Catalyzed Asymmetric Allylic Alkylation of Indoles and Pyrroles by Chiral Alkene-Phosphine Ligands

A variety of chiral binaphthyl-based terminal-alkene-phosphine hybrid ligands were synthesized in four steps with (S)-BINOL as a starting material and utilized for the Pd-catalyzed enantioselective allylic alkylations of indoles and pyrroles to afford the desired products in high yields with good to excellent ee’s

Pd-Catalyzed Asymmetric Allylic Alkylation of Indoles and Pyrroles by Chiral Alkene-Phosphine Ligands

A variety of chiral binaphthyl-based terminal-alkene-phosphine hybrid ligands were synthesized in four steps with (S)-BINOL as a starting material and utilized for the Pd-catalyzed enantioselective allylic alkylations of indoles and pyrroles to afford the desired products in high yields with good to excellent ee’s

Synthesis of thienyl-substituted isochromene derivatives through gold-catalyzed tandem heteroarylation/cycloisomerization of <i>ortho</i>-alkynylbenzaldehydes with thiophenes

<p>We describe herein a gold-catalyzed tandem heteroarylation/cycloisomerization reaction of <i>ortho</i>-alkynylbenzaldehydes with thiophenes. By this reaction, a variety of 1-(thiophen-2-yl)-1<i>H</i>-isochromene derivatives can be obtained in good yield.</p

Silver-Catalyzed Domino Reaction of ortho-Carbonylated Alkynyl-Substituted Arylaldehydes with Conjugated Dienes: Stereoselective Access to Indanone-Fused Cyclohexenes

A silver-catalyzed domino reaction of ortho-carbonylated alkynyl-substituted arylaldehydes with conjugated dienes is described here. Through this reaction, the synthesis of a variety of indanone-fused cyclohexene derivatives can be achieved efficiently. The formation of these tricyclic products could involve a key Diels–Alder reaction of <i>in situ</i> generated indanenone dienophiles with conjugated dienes. Particularly, the products can be accomplished in a high <i>endo</i>/<i>exo</i> selective way