A Practical Nonflammable Na₄B₃₆H₃₄-Based Hydroborate Electrolyte for High-Voltage All-Solid-State Sodium Batteries

High-voltage solid electrolytes (SEs) are highly desired for the development of safe and high-energy-density all-solid-state batteries (ASSBs). Herein, a nonflammable conjuncto-hydroborate of Na4B36H34 is developed with a wide electrochemical stability window (ESW) of up to 6.9 V. Density functional theory calculations reveal an enlarged Na-ion diffusion pathway and fast dynamics of [B36H34]4–, contributing to the fast Na+ conduction in Na4B36H34. Remarkably, the mixed-anion Na4B36H34-7Na2B12H12 SE demonstrates high ionic conductivity (1.02 × 10–3 S cm–1), wide ESW (5.5 V), high Na+ transference number (0.97), low electronic conductivity, low density (1.1709 g cm–3), good compressibility, decent mechanical strength, nonflammability, and solubility. Moreover, the Na/Na4B36H34-7Na2B12H12/Na symmetrical cell can maintain long-term cyclability over 200 h at 0.1 mA cm–2. In addition, a 4.5 V high-voltage Na3V2(PO4)2O2F/Na battery with good cycling stability was fabricated using Na4B36H34-7Na2B12H12 as SE. The proposed Na4B36H34-based hydroborate electrolyte turns out to be a promising SE candidate for the practical application of high-voltage and high-energy-density ASSBs

Table_1_MicroRNAs as Biomarkers for the Diagnosis of Ankylosing Spondylitis: A Systematic Review and Meta-Analysis.DOCX

Background: Abnormal expression levels of microRNAs (miRNAs) were observed in ankylosing spondylitis (AS) in recent articles, suggesting that miRNAs may be used as biomarkers for AS diagnoses. In this paper, we conducted a meta-analysis to identify the overall diagnostic accuracy of miRNA biomarkers in AS patients.Methods: An extensive search was undertaken in PubMed, Embase, Cochrane databases, and Wan Fang database up to 30 December 2020 using the following key words: (“microRNAs” or “microRNA” or “miRNA” or “miR” or “RNA, Micro” or “Primary MicroRNA”) and (“Spondylitis Ankylosing” or “Spondyloarthritis Ankylopoietica” or “Ankylosing Spondylarthritis” or “Ankylosing Spondylarthritides” or “Spondylarthritides Ankylosing” or “Ankylosing Spondylitis”) and (“blood” or “serum” or “plasma”). Statistical evaluation of dysregulated miRNAs using the sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and the area under the curve (AUC).Results: Twenty-nine articles reporting on the miRNAs of AS were included. A total of 42 miRNAs were observed to be up-regulated and 45 miRNAs were down-regulated in the AS cases compared with the controls. Besides, 29 studies from nine articles were included in our meta-analysis. The pooled sensitivity, specificity, PLR, NLR, DOR, and AUC were 0. 76 (95% CI, 0.70–0.81), 0.80 (95% CI, 0.74–0.85), 3.75 (95% CI, 2.82–5.01), 0.30 (95% CI, 0.24–0.39), 12.32 (95% CI, 7.65–19.83), 0.85 (95% CI, 0.81–0.88), respectively, suggesting a good diagnostic accuracy of miRNAs for AS.Conclusions: Circulating miRNAs are deregulated in AS patients. miRNAs may be used as a relatively non-invasive biomarkers for the detection of AS.</p